Clinical trials · Chicago, IL
Atrial fibrillation clinical trials in Chicago
We’re tracking 24 recruiting atrial fibrillation studies with a site in or near Chicago — including Early Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Chicago
- NCT06511505Recruiting
Testing AI to find hidden heart conditions from ECGs
This study uses an AI tool to look at your ECG (a simple heart test) to help find early signs of atrial fibrillation (an irregular heartbeat) or structural heart disease (changes in heart structure). It aims to see if the AI can help doctors catch these conditions sooner, even in people who don't yet have symptoms.
Chicago, IllinoisAges 40 years+ - NCT06499857RecruitingPhase 3
Semaglutide for atrial fibrillation and weight loss
This study tests whether a weekly injection of semaglutide (the same drug in Wegovy and Ozempic) can help people with atrial fibrillation lose weight and improve their heart condition. It's for people with AF who also have obesity, and may or may not plan to have a heart procedure called catheter ablation.
Chicago, IllinoisAges 18–75 - NCT06063538RecruitingEarly Phase 1
Preventing irregular heartbeat after heart surgery with amiodarone
This trial tests if placing a small amount of amiodarone medicine near the heart during open-chest surgery can help prevent a common irregular heartbeat (atrial fibrillation) that often happens after heart surgery.
Chicago, IllinoisAges 20–85 - NCT02347111RecruitingPhase 4
Genetic study to guide antiarrhythmic drugs for atrial fibrillation
This study looks at how a person’s genetics may affect how well and safely antiarrhythmic medicines work for atrial fibrillation (AF). If you join, you may get medicine options like flecainide or sotalol, and researchers compare outcomes to genetic information.
Chicago, IllinoisAges 18–100 - NCT05407415Enrolling by invitation
Using a phone ECG monitor to improve care for atrial fibrillation
This trial studies whether sending heart rhythm recordings from a phone (using the KardiaMobile ECG device) can improve health care use and patient experience for people with atrial fibrillation. It may help your care team monitor you more smoothly—if you meet the study requirements.
Chicago, IllinoisAges 18–90 - NCT03907046RecruitingPhase 3
Blood thinner study to prevent stroke after brain bleed
This Phase 3 study tests whether a blood thinner (apixaban) can help prevent another stroke and support recovery after you’ve had a brain bleed. You would be assigned to a treatment group, and the study checks safety and whether strokes can be reduced without causing dangerous bleeding.
Chicago, IllinoisAges 18 years+ - NCT06989775Recruiting
BoxX-NoAF Trial: Preventing Stroke During Heart Surgery
This trial tests a device to close a small pouch in the heart during planned bypass surgery, to help prevent future strokes. It is for people who have never had an irregular heartbeat and are at higher stroke risk due to age and other factors.
Chicago, IllinoisAges 65 years+ - NCT07324772Recruiting
Exercise program to improve symptoms in atrial fibrillation and heart failure
This study tests if starting a supervised exercise program can help older adults with both atrial fibrillation and a type of heart failure called HFpEF feel better and have a better quality of life. You'll be asked to join exercise sessions and have regular check-ins to see how you're doing.
Chicago, IllinoisAges 60–99 - NCT05836987RecruitingPhase 3
Smartwatch-guided blood thinners for intermittent atrial fibrillation
This study tests whether using a smartwatch to monitor your heartbeat can safely guide when to take blood thinners. If you have intermittent atrial fibrillation, you may be able to avoid taking blood thinners when your heart rhythm is normal.
Chicago, IllinoisAges 22–85 - NCT05978466Recruiting
Managing atrial fibrillation outcomes registry
This registry collects information on people with atrial fibrillation to understand how different treatments affect their health and quality of life over time.
Chicago, IllinoisAges 18 years+ - NCT03168659Recruiting
Study of HeartLight during catheter ablation for irregular heartbeat
This study looks at the HeartLight device during a procedure to treat atrial fibrillation (an irregular heart rhythm) that comes and goes. It is meant for adults whose symptoms continue even after trying at least one anti-arrhythmia medicine.
Chicago, IllinoisAges 18 years+ - NCT06578104Recruiting
Pulsed AF Study: PulseSelect Catheter for Afib
This study tests a new way to treat atrial fibrillation (Afib) using a special catheter system called PulseSelect that delivers short bursts of energy to create scar tissue in the heart. It is for people whose Afib comes and goes or stays for a while but not more than a year, and who have not had a prior ablation procedure or have a pacemaker or defibrillator.
Chicago, IllinoisAges 18 years+ - NCT06957366Recruiting
Managing Blood Thinners Before High-Risk Surgery
This study looks at how to safely manage your blood thinner (DOAC) around the time of a planned, high-bleed-risk surgery or procedure involving a spinal needle. The goal is to find the best way to stop and restart your medication to prevent bleeding and clotting problems.
Evanston, IllinoisAges 18 years+ - NCT05963698Recruiting
Closing off a heart pouch to prevent stroke
This study tests a procedure that seals off the left atrial appendage (a small heart pouch) to help prevent stroke in people with atrial fibrillation. You may be considered if your stroke risk is high and you are already on blood-thinner medicine.
Evanston, IllinoisAges 18 years+ - NCT06844227Recruiting
Virtual Visit to Manage Blood Thinners Around Surgery
This study looks at whether a virtual visit can safely manage your blood thinners around the time of a planned surgery. You would stop your medication before the procedure and restart it after, but all instructions and check-ins happen remotely (phone or video).
Evanston, IllinoisAges 18–100 - NCT06056271Recruiting
Tracking AI use during AF ablation in real-world care
This trial is for people with atrial fibrillation (AF) who are having or recently had a catheter ablation procedure. It looks at how using a special artificial intelligence tool, called VX1, during the procedure affects patient outcomes.
Evanston, IllinoisAges 21 years+ - NCT04088071Recruiting
Ablation for heart rhythm problems using a specific technology
This study looks at how well catheter ablation works for treating certain heart rhythm disorders (like atrial fibrillation or ventricular arrhythmias) using a specific brand of catheters. The aim is to gather real-world data to better understand the procedure's outcomes.
Evanston, IllinoisAges 18 years+ - NCT06376916RecruitingPhase 3
Testing magnesium doses for fast heart rate in atrial fibrillation
This trial tests whether giving a higher dose of magnesium (4 grams) compared to a lower dose (2 grams) or a placebo can help control a fast heart rate during atrial fibrillation. It may help patients who are already receiving diltiazem.
Oak Lawn, IllinoisAges 18 years+ - NCT05712200RecruitingPhase 3
Abelacimab for atrial fibrillation when blood thinners aren’t suitable
This Phase 3 study tests whether abelacimab can prevent stroke and other blood-clot problems in people with atrial fibrillation (or atrial flutter) who cannot safely take usual mouth blood thinners. It also looks at safety, especially bleeding risk.
Park Ridge, IllinoisAges 65 years+ - NCT06335082Enrolling by invitation
Study of Farapulse ablation for atrial fibrillation
This registry is collecting information to see how well the Farapulse PFA system works and how safe it is for treating atrial fibrillation (AF), a common heart rhythm problem. If you are scheduled to have an ablation for AF with this system, this study will follow your progress.
Glenview, IllinoisAges 18 years+ - NCT07626411RecruitingPhase 3
Blood Thinner Study for Irregular Heartbeat
This study tests a new blood thinner to prevent strokes and blood clots in people with atrial fibrillation (a common heart rhythm problem). You may qualify if you have atrial fibrillation and at least one risk factor for stroke, or if you've never taken a blood thinner before.
Munster, IndianaAges 18 years+ - NCT07430956RecruitingPhase 3
Stroke prevention in atrial fibrillation without standard blood thinners
This trial tests a new medication to prevent strokes and blood clots in people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard blood thinners. The drug works by blocking a different clotting factor, which may lower bleeding risks.
Munster, IndianaAges 18 years+ - NCT07227532Recruiting
Testing a new catheter for atrial fibrillation treatment
This study tests a new catheter system, called Varipulse, to see if it's safe and effective for treating atrial fibrillation (AF), a heart rhythm problem. People with short-lasting AF who haven't been helped by medication may be able to join.
Naperville, IllinoisAges 22 years+ - NCT07175428RecruitingPhase 2
Safety of a New Blood Thinner in AFib Patients
This study tests the safety of a new blood thinner for people with atrial fibrillation (AFib) who need long-term stroke prevention. If you qualify, the study will compare this medication to standard anticoagulation therapy.
Merrillville, IndianaAges 18 years+
Hear when a new Atrial fibrillation trial opens near Chicago, IL
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Atrial fibrillation trials in other cities
Where these studies are running near Chicago
Institutions with a site for the recruiting atrial fibrillation studies listed above.
- Northwestern University · 6 studies
- Rush University Medical Center · 3 studies
- University of Chicago · 3 studies
- Indiana Medical Research · 2 studies
- Midwest Cardiovascular Institute · 2 studies
- NorthShore University HealthSystem-Evanston Hospital · 2 studies
- Profound Research, Powers Health Medical Group · 2 studies
- Advocate Christ Medical Center
What taking part in a atrial fibrillation study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting atrial fibrillation studies in Illinois.
Common questions
- Are there atrial fibrillation clinical trials near Chicago?
- Yes. We're currently tracking 24 recruiting atrial fibrillation studies with a site near Chicago, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a atrial fibrillation study near Chicago?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Chicago to take part?
- Not necessarily. These studies have a site near Chicago, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New atrial fibrillation studies open near Chicago regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.