Bipolar Disorder I or II clinical trials

Dextromethorphan for OCD and related anxiety conditions

This trial studies dextromethorphan, a medicine sometimes used for cough, to see if it can reduce symptoms in OCD and similar conditions. It may help people whose intrusive thoughts or related worries are still challenging despite current care.

Breathing CO2 test to predict which anxiety therapies won’t work

This study uses a controlled breathing test (inhaling CO2 or breathing faster) to see if it can predict whether exposure-based therapy will help your anxiety disorder. If you are in the right group, the results may help doctors choose more effective treatment earlier.

CBT therapy study for anxiety and brain circuit changes

This trial studies whether a specific form of talk therapy (CBT) changes brain activity in people with moderate anxiety. It may help your care team understand what works best and how brain “circuits” respond to treatment.

Study of OriCAR-017 for relapsed or refractory multiple myeloma

This trial tests a new type of CAR-T cell therapy called OriCAR-017 for people with multiple myeloma that has come back or not responded to treatment. It is for patients who have already tried several treatments, including ones that target BCMA, and their last treatment stopped working.

Testing a new ketamine-like drug for hard-to-treat depression

This study tests a new experimental drug (2R,6R)-HNK, a chemical related to ketamine, given by IV infusion to see if it can help people with depression that hasn't improved with other treatments. The goal is to find a new option for people who have not found relief from standard antidepressants.

Brain learning mechanisms and substance use control

This study looks at how certain learning mechanisms in the brain (called Pavlovian conditioning) influence your ability to control alcohol or drug use. It may help explain why some people have trouble stopping, and could lead to better treatments. You'll fill out questionnaires and likely have a brain scan (MRI).

Online therapy for teens with anxiety or depression

This study tests an online therapy program for teens aged 13–17 who feel anxious, depressed, or both. The program is designed to help you understand and manage these feelings through short, internet-based sessions, and you can do it from home.

Study of an experimental psychedelic-like drug for depression (CYB003)

This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.

Hypnotherapy and Brain Activity in Generalized Anxiety Disorder

This study uses EEG (a brain wave test) to see how Ericksonian hypnotherapy, a gentle type of hypnosis, affects brain activity and anxiety symptoms in people with Generalized Anxiety Disorder (GAD) who are not currently in treatment or taking medication for anxiety.

An Open-Label Tirzepatide Trial for Comorbid Obesity and Stimulant Use Disorder

Comparing two talk therapies for anxiety and PTSD

This trial tests two types of therapy — metacognitive therapy and cognitive-behavioral therapy — to see which works better for people with certain anxiety disorders or PTSD. You would be randomly assigned to one of the treatments and attend regular sessions.

Adding chemo or immunotherapy before surgery for advanced head and neck cancer

This trial tests whether giving chemotherapy or chemotherapy plus immunotherapy before surgery can improve outcomes for people with advanced head and neck cancer that has come back or not gone away after prior treatment.

Brain stimulation and therapy for cocaine use

This study tests a combination of brain stimulation (rTMS) and talk therapy (CBT) to help people reduce cocaine use. It's for adults who want treatment and use cocaine at least once a week.

Memory training for PTSD symptoms

This study tests a computer-based memory training program for people with PTSD. It aims to see if this training can help reduce PTSD symptoms by improving how your brain processes memories. The study involves 8 remote sessions over 4 weeks and two MRI scans to look at brain changes.

Prednisone for adults with autism and immune issues

This trial tests if the steroid prednisone can help adults with moderate-to-severe autism who also have signs of immune system problems, like autoimmune disease or inflammation. It might offer a new treatment option for people whose autism is linked to immune activity.

Using brain signals to predict CBT success for mood or sleep issues

This study tests whether brain measurements can help predict who will benefit from a type of talk therapy called CBT (cognitive behavioral therapy). If you have depression, social anxiety, or insomnia, your brain “response variability” may be used to personalize or improve treatment planning.

Brain-focused ultrasound for opioid addiction-related substance use

This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.

Testing tividenofusp alfa vs idursulfase for MPS II

This trial compares a new treatment (tividenofusp alfa) to the current standard treatment (idursulfase) in children and young adults with MPS II. It’s looking to see which option works better and is safe, especially based on age and whether the disease affects the brain.

Personalized psychiatry meds using gene test results

This study compares a personalized medication plan based on your genes versus standard dosing for people with depression, anxiety, or psychosis. It may help your clinician choose a safer or more effective dose or medicine by using pharmacogenomics (gene-informed prescribing).

Avatar vs supportive sessions to cut cannabis use

This study compares two types of talking/learning sessions—one using an “avatar” (computer-based character) and one using regular supportive sessions—to reduce cannabis use. It is meant for adults with psychotic disorders who also meet criteria for cannabis use disorder.

Therapy for social anxiety in Veterans with trauma symptoms

This study compares two kinds of treatment for social anxiety disorder to see which one works better for Veterans. It focuses on people who also have significant posttraumatic stress symptoms (trauma-related symptoms).

Social anxiety and public speaking fear study

This study tests if reward processing training combined with exposure therapy helps people with social anxiety disorder who are afraid of public speaking. Participants will complete therapy sessions and possibly an MRI brain scan.

Personalized physical activity program for ovarian and endometrial cancers

This study tests whether a personalized, automated physical activity program (using a Fitbit and continuous glucose monitor) can improve immune function and health outcomes in people with advanced ovarian, primary peritoneal, fallopian tube, or newly diagnosed endometrial cancer. You'll wear an activity tracker, answer questionnaires, and provide blood and stool samples at Roswell Park.

Extended therapy for borderline personality disorder

This study tests a longer version of a therapy called Good Psychiatric Management for people with borderline personality disorder (BPD). It aims to see if the extended program helps symptoms more than usual care.