Clinical trials
Brachytherapy clinical trials
Below are recruiting brachytherapy clinical trials, each written for real people, not researchers. We’re tracking 98 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07141732RecruitingPhase 1
Brain radiation therapy during surgery for new glioblastoma
This trial tests giving a precise dose of radiation directly to the tumor area during surgery for newly diagnosed glioblastoma. The goal is to destroy remaining tumor cells immediately after removal, which may improve outcomes.
Moscow, MoscowAges 40–75 - NCT05242861Recruiting
Reviewing outcomes after brachytherapy for women’s cancers
This study looks back at medical records to understand results after brachytherapy (a form of cancer radiation delivered from inside or close to the tumor) in women with gynecologic cancer. It may help doctors improve future treatment decisions, but you would not have to receive an experimental treatment.
Hangzhou, ZhejiangAges 18–80 - NCT07426055RecruitingPhase 2/Phase 3
Prostate cancer radiation boost comparison study
This trial compares two types of radiation treatments for prostate cancer that has not spread to lymph nodes or other parts of the body. It tests whether adding a higher dose of radiation to the main tumor helps control the cancer better than standard radiation alone.
Zamość, Lublin VoivodeshipAges 18 years+ - NCT07300566Recruiting
Focal versus whole-gland radiation boost for localized prostate cancer
This trial compares two ways of giving a radiation boost (brachytherapy) to the prostate for men with localized prostate cancer. One method targets only the visible tumor, while the other treats the whole gland, and the study aims to see if the focal approach works as well with fewer side effects.
London, OntarioAges 18 years+ - NCT06982469Recruiting
High-dose radiation for prostate cancer return after surgery
This trial tests a high-dose radiation treatment (brachytherapy) that places tiny radioactive seeds directly into the area where your prostate was. It is for men whose prostate cancer has returned only in that area after having their prostate removed.
Pamplona, Foral Community of NavarreAges 18–80 - NCT03422198RecruitingPhase 3
Short course vaginal radiation after hysterectomy
This trial tests a short course of targeted vaginal radiation (brachytherapy) after surgery for certain early endometrial cancer. It may help prevent the cancer from coming back in the vaginal area after the uterus has been removed.
Palo Alto, CaliforniaAges Any age - NCT01913106RecruitingPhase 1/Phase 2
Testing valacyclovir with an added cancer gene in prostate radiation
This Phase 1/2 study tests whether adding a cancer-targeting gene therapy (HSV-tk) and the antiviral medicine valacyclovir to brachytherapy can better treat recurrent prostate cancer in the prostate area. It may help by making cancer cells more vulnerable to the treatment.
Houston, TexasAges Any age - NCT03249519Recruiting
Radiation plus heat for advanced cervical cancer
This trial studies whether adding controlled heat (“hyperthermia”) to radiation therapy (or radiation with chemotherapy) can improve outcomes in advanced cervical cancer. It focuses on people who can safely receive intensive pelvic radiation and heat treatment.
ErlangenAges 18 years+ - NCT02391051RecruitingPhase 2
Targeted radiation for low-risk prostate cancer
This trial tests a focused form of radiation placed inside the prostate to treat only the cancer area in people with low-risk prostate cancer. It aims to control the cancer while limiting treatment to a smaller area.
ErlangenAges 18 years+ - NCT03238378Recruiting
Radiation boost plus warming for recurrent head and neck tumors
This trial tests a “salvage” treatment that combines targeted radiation (brachytherapy) with controlled body warming (hyperthermia) for head and neck cancer that has come back. It may help by better shrinking tumors while fitting the treatment to the tumor’s exact location.
ErlangenAges 18 years+ - NCT05608213RecruitingPhase 3
Lenvatinib plus radiation seeds vs lenvatinib alone for liver cancer
This Phase 3 trial compares lenvatinib plus implanted radiation seeds versus lenvatinib alone in people with liver cancer that no longer responds to TACE. It aims to improve how long patients can control the cancer inside the liver.
Guangzhou, GuangdongAges 18–75 - NCT05772923Recruiting
Testing rectal cancer organ-preservation after radiation
This trial compares two ways to preserve the rectum/avoid major surgery after radiation: a focused contact x-ray treatment versus waiting longer and then removing only a small area if needed. It may help some people keep more normal bowel function while still controlling the cancer.
Nijmegen, GelderlandAges 18 years+ - NCT04583254RecruitingPhase 2
Shorter radiation plan for certain early cervical cancers
This trial tests a feasibility (“can it be done safely?”) approach that delivers radiation in a shorter schedule for some cervical cancer patients. It also uses weekly cisplatin chemotherapy and includes a radiation procedure called brachytherapy to improve treatment effectiveness.
Kelowna, British ColumbiaAges 18 years+ - NCT06284031Recruiting
Cervical cancer brachytherapy with needles in 3 sessions
This trial tests a special type of radiation, called brachytherapy, given in 3 sessions using thin needles. It is for people with cervical cancer that has not spread too far, and who have already had standard radiation treatment.
SingaporeAges 21 years+ - NCT07786493Recruiting
3D-printed internal radiation for rectal cancer
This study tests a new way to deliver internal radiation therapy (brachytherapy) to rectal cancer using a 3D-printed guide. It may help people who cannot have or do not want surgery, with the goal of preserving the rectum.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT07468903Recruiting
Focal radiation for prostate cancer with HDR brachytherapy
This trial tests a targeted radiation treatment called HDR brachytherapy for prostate cancer that hasn't spread. It aims to treat only the cancer spots seen on MRI, which may reduce side effects.
Los Angeles, CaliforniaAges 40 years+ - NCT05984511Recruiting
Combined treatment for liver cancer with portal vein tumor thrombus
This trial tests whether adding immunotherapy (atezolizumab/bevacizumab) and a type of internal radiation (I-125 seeds) to standard chemoembolization (TACE) can help people with liver cancer that has spread into the main liver blood vessel (portal vein). It aims to control the tumor and improve outcomes.
Guangzhou, GuangzhouAges 18–75 - NCT04100174RecruitingPhase 2
HDR radiation boost for prostate cancer during standard treatment
This study tests adding a targeted “boost” of HDR (high-dose-rate) internal radiation to the prostate along with standard external beam radiation. It may help improve cancer control while keeping the treatment focused on the area seen on scans and biopsy.
Montreal, QuebecAges Any age - NCT07292298RecruitingPhase 2
Rectal cancer brachytherapy after treatment to avoid surgery
This trial tests a special type of internal radiation (brachytherapy) for people with low-lying rectal cancer that did not fully go away after standard chemoradiation and chemotherapy. The goal is to shrink the remaining tumor enough to avoid major surgery like removing the rectum or colostomy.
Aurora, ColoradoAges 18–100 - NCT03861507Recruiting
Power ultrasound helps locate prostate treatment needles
This trial studies whether a special ultrasound method (power Doppler ultrasound) can better guide where needles go during high-dose-rate radiation treatment for prostate cancer. The goal is to improve targeting during the procedure while you receive standard treatment.
London, OntarioAges 18 years+ - NCT04705467Recruiting
3D scanning of needles during gynecologic radiation treatment
This study uses 3D imaging to help guide needle-based radiation treatment for certain gynecologic cancers. If you are already scheduled to receive this type of brachytherapy, the trial may help make the treatment planning more accurate.
London, OntarioAges 18 years+ - NCT07182279RecruitingPhase 1/Phase 2
Internal radiation before prostate surgery for high-risk cancer
This trial tests a treatment approach for newly diagnosed, high-risk prostate cancer. You would receive a short course of internal radiation (high-dose-rate brachytherapy) before surgery to remove your prostate. The goal is to see if this combination is safe and works better than surgery alone.
Houston, TexasAges 40 years+ - NCT05715502Recruiting
Targeted radiation for prostate cancer that came back
This study tests a focused (“salvage”) brachytherapy—radiation placed directly near the prostate—to treat prostate cancer that has returned after earlier radiation. It may help control the tumor while limiting radiation exposure to surrounding tissues, based on how well people fit the study’s safety and cancer details.
Poznan, Greater Poland VoivodeshipAges 18 years+ - NCT07152678RecruitingPhase 2
Brachytherapy with radiation and immunotherapy for esophageal cancer
This trial tests combining brachytherapy (a type of internal radiation) with immunotherapy (nivolumab) for people with advanced esophageal cancer that has not fully responded to initial chemoradiation. The goal is to see if this targeted approach can improve outcomes.
Huwei, Yunlin CountyAges 18–85
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Common questions
- Are there clinical trials for brachytherapy?
- Yes. Clin2 currently lists 98 recruiting brachytherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brachytherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brachytherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.