Clinical trials
Brain Cancer clinical trials
Below are recruiting brain cancer clinical trials, each written for real people, not researchers. We’re tracking 249 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03175224RecruitingPhase 2
Test drug APL-101 for lung or other tumors with MET changes
This Phase 2 study tests APL-101 to shrink advanced cancers that have certain MET-related changes, including specific MET mutations, MET gene amplification, or MET fusions. It may help people whose tumors have run out of standard treatment options.
Los Angeles, CaliforniaAges 18 years+ - NCT05859659Recruiting
Hope HOPE study for glioma using pathology and MRI
This study looks at glioma (a type of brain tumor) and uses brain tissue testing, MRI scans, and related measurements to better understand the disease. You may benefit by being closely assessed with MRI and study follow-up, though it’s not necessarily testing a new medicine based on the listed criteria.
Beijing, Beijing MunicipalityAges 18–90 - NCT07130786RecruitingPhase 2
Preventing seizures with medication for brain tumors in movement area
This study tests whether giving a seizure medication (levetiracetam) to people with brain tumors in the movement area can prevent seizures. It compares taking the medication to not taking it, starting before any seizure occurs.
Boston, MassachusettsAges 18 years+ - NCT05504772Recruiting
Personalized genetic testing for children with cancer
This trial studies how personalized (tailored) genetic testing can help guide care for children with cancer. It may help match treatment choices to each child’s genetic risk, and it includes optional return of germline (inherited) test results.
AdelaideAges birth–25 years - NCT06611306Recruiting
Targeted whole-brain radiation for breast cancer that spread to the brain
This trial tests a newer, more targeted way to give whole-brain radiation for breast cancer that has spread to the brain. It aims to see if this approach can be as effective while causing fewer side effects compared to the standard whole-brain radiation.
London, LondonAges 16–100 - NCT05769010RecruitingPhase 2
HER2-positive or low breast cancer brain metastasis drug study
This Phase 2 study tests SHR-A1811 in people with HER2-positive (or HER2-low) advanced breast cancer that has spread to the brain. It aims to shrink brain tumors and control the cancer in the brain, especially when there was no need for urgent local treatment like radiation or surgery.
Zhengzhou, HenanAges 18–75 - NCT06457906RecruitingPhase 3
Focused radiation vs whole brain radiation for up to 10 lung cancer brain spots
This trial compares two types of radiation for people with small cell lung cancer that has spread to the brain (10 or fewer spots). One approach uses focused radiation only on the tumors, the other treats the whole brain while trying to protect memory. The goal is to see which works better with fewer side effects.
Beijing, Beijing MunicipalityAges 18–80 - NCT06476093Recruiting
Radiation plus anlotinib for lung cancer brain spread
This trial tests a combination of focused radiation (stereotactic radiosurgery) and an oral targeted therapy called anlotinib for people with non-small cell lung cancer that has spread to the brain. It may offer a way to control brain metastases without more invasive procedures.
Lianyungang, JiangsuAges 18–80 - NCT07402343RecruitingPhase 2
Tarlatamab for small cell lung cancer brain metastases
This trial tests a new drug, tarlatamab, for people with small cell lung cancer that has spread to the brain. It aims to see if the drug can shrink brain tumors and help you live longer, especially if you have not had brain radiation before.
AmsterdamAges 18 years+ - NCT07136428RecruitingPhase 1/Phase 2
Asciminib for HER2+ breast cancer that has spread to the brain
This trial tests the drug asciminib for people with HER2-positive breast cancer that has spread to the brain and is growing. It may be an option if you have already tried standard treatments like T-DXd and tucatinib.
Durham, North CarolinaAges 18 years+ - NCT05106296RecruitingPhase 1
Chemo-immunotherapy with ibrutinib and indoximod for pediatric brain tumors
This Phase 1 study tests a combination treatment (ibrutinib plus indoximod along with chemotherapy) for children with brain tumors that have come back or are hard to treat. It may help shrink active tumor or control the disease when standard treatments can’t cure it.
Augusta, GeorgiaAges 3–25 - NCT05864274Recruiting
Cognitive training for people on chemotherapy
This trial studies a phone or tablet brain-training program to help with “cancer-related cognitive impairment,” or thinking and memory problems that can happen during chemotherapy. If you’re newly diagnosed with certain gynecologic cancers and are receiving chemotherapy, this may help you see whether the training improves cognitive symptoms.
Birmingham, AlabamaAges 18–90 - NCT05317858RecruitingPhase 3
Open the brain’s blood barrier to treat lung cancer brain spots
This trial tests whether using focused ultrasound to temporarily open the brain’s blood barrier—plus standard immune therapy—can better treat non-small cell lung cancer (NSCLC) that has spread to the brain. It aims to help medicines reach the brain tumor spots more effectively, while still using the usual lung cancer treatment.
Phoenix, ArizonaAges 18–100 - NCT06804655RecruitingPhase 2
Personalized drug testing for stubborn brain tumors
This study tests a new way to choose treatment for people with brain tumors that have not responded to standard therapies. Your tumor sample is analyzed in the lab to find which drugs might work best for you, and then you receive a personalized treatment plan.
Basel, Basel-LandschaftAges 18 years+ - NCT05700721RecruitingPhase 2
Niraparib and dostarlimab for cancer with growing brain spots
This trial studies whether the medicines niraparib and dostarlimab can slow advanced cancers that have active, growing brain metastases. It is meant for people whose brain tumors can be measured on MRI and who have had at least one previous treatment.
Houston, TexasAges 18 years+ - NCT04343157RecruitingPhase 2
Image-guided radiation for brain tumors that protects thinking
This trial tests a special type of radiation therapy for brain tumors that aims to protect your memory and thinking skills. It may be an option if you have certain brain tumors or a small number of brain metastases.
San Diego, CaliforniaAges 18 years+ - NCT05588141RecruitingPhase 1/Phase 2
Zotiraciclib for recurrent brain tumors with IDH mutations
This early-phase study tests zotiraciclib in people with recurring diffuse gliomas (brain tumors) that have an IDH1 or IDH2 mutation. It may help slow the tumor or shrink it by targeting a specific change in tumor biology.
Bethesda, MarylandAges 15 years+ - NCT06702826RecruitingPhase 2
Cadonilimab plus radiation for lung cancer brain mets
This trial tests a combination of a targeted immunotherapy drug (cadonilimab) with a precise type of radiation to treat brain tumors that have grown after initial lung cancer treatment. The goal is to see if this approach can safely shrink brain metastases and improve outcomes.
Changsha, HunanAges 18–75 - NCT07462507RecruitingPhase 2
Brain tumor inflammation study using a new imaging agent
This trial tests a new PET scan tracer to see inflammation in brain tumors that have not been treated with radiation. It may help doctors better understand and monitor these tumors.
St Louis, MissouriAges 18 years+ - NCT06991101RecruitingPhase 2
Ruxolitinib with radiation and chemo for newly diagnosed glioblastoma
This trial tests whether adding the drug ruxolitinib to standard radiation and chemotherapy (temozolomide) helps people with a newly diagnosed brain tumor called glioblastoma. It aims to see if the combination keeps the tumor from growing longer than the standard treatment alone.
Miami, FloridaAges 18 years+ - NCT06793332RecruitingPhase 2
Ivonescimab and Trodelvy for breast cancer with brain metastases
This trial tests two drugs (Ivonescimab and a Trop2 ADC) for people with triple-negative breast cancer that has spread to the brain. It aims to see if this combination can shrink brain tumors and help patients live longer.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05376878RecruitingPhase 4
PET/MRI scan to guide treatment in HER2+ brain metastatic breast cancer
This trial tests a special PET/MRI imaging scan using a labeled drug to help doctors evaluate HER2+ breast cancer that has spread to the brain. It focuses on patients who plan to receive fam-trastuzumab deruxtecan, a targeted cancer medicine, and aims to see how well the scan can support treatment decisions.
Duarte, CaliforniaAges 18 years+ - NCT07619534Recruiting
Collecting Spinal Fluid from Advanced Breast Cancer Patients
This study collects spinal fluid samples from people with advanced (metastatic) HER2-positive or triple-negative breast cancer who have never had, and currently do not have, cancer spread to the brain. Researchers want to understand how cancer cells might reach the nervous system and develop better treatments.
Bethesda, MarylandAges 18–120 - NCT06835426Recruiting
Imaging removed tissue during cancer surgery
This study tests a high-resolution PET-CT scanner that takes pictures of tissue removed during surgery to help doctors see if all the cancer has been removed. You might qualify if you are having surgery for a range of cancers including breast, prostate, thyroid, skin, gastrointestinal, or brain tumors.
Ghent, Oost VlaanderenAges 18 years+
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Common questions
- Are there clinical trials for brain cancer?
- Yes. Clin2 currently lists 249 recruiting brain cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Gastric Cancer, Gastroesophageal Junction Cancer
- Brain Metastases From Non-small Cell Lung Cancer (NSCLC)
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Brain Metastases From Breast Cancer
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.