Clinical trials
Brain Diseases clinical trials
Below are recruiting brain diseases clinical trials, each written for real people, not researchers. We’re tracking 336 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05444907Recruiting
Testing treatment response in DBS-related mania in Parkinson’s
This study is looking at people with Parkinson’s who developed mania (a high-energy mood episode) after deep brain stimulation (DBS) was turned on or its settings were changed. It may help doctors better understand why this happens and how to manage it safely.
LisbonAges 18 years+ - NCT06643013Recruiting
Targeting brain blood vessels to help small vessel disease
This study tests a drug that targets a protein called TSPO to see if it can improve the function of the cells lining the small blood vessels in the brain of people with cerebral small vessel disease. It may help with mild memory or thinking problems.
LondonAges 60–90 - NCT07754721Recruiting
Diet and lifestyle program for chronic acid reflux
This study tests a comprehensive program that combines diet and lifestyle changes to help people with chronic acid reflux (heartburn, acid regurgitation, or chest pain) feel better. It looks at how these changes can improve your overall health and reduce symptoms.
Hualien City, TaiwanAges 18–79 - NCT06188793Recruiting
Virtual reality for IBD pain during hospital stay
This study tests if using virtual reality can help manage pain for people with inflammatory bowel disease (IBD) while they are in the hospital. It may offer a drug-free way to feel better.
Ann Arbor, MichiganAges 18 years+ - NCT06884722Recruiting
Brain study of social perception in Parkinson's disease
This study uses brain scans to understand how people with Parkinson's disease process social cues, like faces and emotions. It may help researchers learn more about how Parkinson's affects social thinking.
BronAges 30–75 - NCT02685969Recruiting
Brain scan study of amyloid and brain sugar use
This study uses brain imaging to measure two things in the brain—amyloid protein and how the brain uses sugar. It may help researchers better understand early brain changes in people in the ALFA project.
Barcelona, CataloniaAges 45–75 - NCT05266417RecruitingPhase 2
Nasal insulin plus glutathione for Parkinson’s symptoms
This Phase 2 study tests whether adding nasal insulin and glutathione can improve Parkinson’s disease symptoms and function. You would use study medicine through the nose while keeping your other treatments mostly the same during the trial.
Davie, FloridaAges 30 years+ - NCT07031687Recruiting
A new brain stimulation study for early Alzheimer's
This study tests a non-invasive brain stimulation method (temporal interference stimulation) to see if it can improve memory in people with early signs of Alzheimer's disease. It aims to understand how the stimulation affects brain function.
Sanya, HainanAges 60–80 - NCT06819020Enrolling by invitation
Adaptive deep brain stimulation for freezing of gait in Parkinson's
This trial tests an adaptive deep brain stimulation (DBS) system designed to improve freezing of gait in Parkinson’s disease. It is for people who still have trouble walking despite medications and are already planning to have DBS surgery.
San Francisco, CaliforniaAges 21–75 - NCT07092995Enrolling by invitation
Understanding freezing of gait in Parkinson's using VR and brain signals
This study uses virtual reality and brain recordings from your DBS device to understand why some people with Parkinson's experience freezing of gait (feeling like your feet are stuck to the ground). You'll be asked to walk in a safe VR environment while researchers monitor your brain activity.
Los Angeles, CaliforniaAges 18 years+ - NCT06561919Recruiting
Speech and language study during brain stimulation treatment
This is an extra part of the STIMPulseControl study that focuses on speech. It looks at how the brain stimulation treatment affects your ability to speak clearly and communicate.
CologneAges 18–70 - NCT04099823Recruiting
MRI study of spinal fluid flow in memory or balance problems
This study uses MRI to look at how spinal fluid moves inside and around the brain. It aims to better understand conditions that can affect thinking, memory, balance, and coordination—such as normal pressure hydrocephalus—or compare with healthy people.
Rochester, MinnesotaAges 18 years+ - NCT05597124RecruitingPhase 2
Exercise program to improve brain health in older Black adults
This Phase 2 study tests whether a structured exercise program can improve brain health in adults age 60 and older who are less active and have early thinking/memory concerns. It may help maintain or improve thinking abilities over time, with medical supervision throughout the study.
Newark, New JerseyAges 60 years+ - NCT06040905Recruiting
Coenzyme Q10 for cognitive decline with high blood sugar and muscle loss
This trial tests whether Coenzyme Q10 supplements help people with mild memory loss or Alzheimer's who also have high blood sugar and early muscle weakness. It aims to see if CoQ10 can improve thinking and daily function.
TaichungAges 50–80 - NCT06821568Recruiting
Home brain stimulation for memory and walking concerns
This study tests if a gentle brain-stimulation device used at home can help older adults who have both memory worries and slower walking. A study partner will help you use the device.
Roslindale, MassachusettsAges 65–90 - NCT06848205Recruiting
Brain pacemaker study for freezing of gait in Parkinson's
This study looks at how a special brain pacemaker (called the Medtronic Percept device) affects walking problems like freezing of gait in people with Parkinson's. It aims to help understand and improve treatment.
Minneapolis, MinnesotaAges 21–75 - NCT07042087Recruiting
Brain health lifestyle study: timed eating and mindfulness
This study tests whether a combination of time-restricted eating and mindfulness can help protect brain health in people with early memory concerns. It lasts 9 months and includes regular guidance and support.
BrnoAges 60–80 - NCT05450237Enrolling by invitation
Testing thinking and memory questionnaires in people with brain injury
This study checks how well certain questionnaire and testing tools work for people who have brain damage from neurologic conditions and ongoing brain inflammation. It may help future patients by improving which tests are most accurate and easy to use.
Pozzilli, IserniaAges 18–80 - NCT07667478Recruiting
Brain stimulation study for early Alzheimer's memory loss
This study tests whether a non-invasive magnetic brain stimulation technique can help improve memory in people with early Alzheimer's disease. It may be an option if you have mild cognitive impairment or mild dementia due to Alzheimer's and have had a positive blood test for Alzheimer's markers.
Houston, TexasAges 55–90 - NCT05573490Recruiting
Lifestyle program study for early-onset Alzheimer’s
This study tests a structured lifestyle intervention to help people with early-onset Alzheimer’s disease. It is designed for adults with confirmed Alzheimer’s-related brain changes, and may help with symptoms or day-to-day functioning.
Indianapolis, IndianaAges 40–75 - NCT05968703Recruiting
Deep brain stimulation study for mild memory trouble in Parkinson’s
This trial looks at a specific type of deep brain stimulation (DBS) to see if it can help people with Parkinson’s who have mild cognitive problems (mild memory/thinking changes). You may also be asked to temporarily stop Parkinson’s medications around research visits to measure effects more clearly.
Stanford, CaliforniaAges 21–80 - NCT06857851Recruiting
Deep brain stimulation study for movement in Parkinson's
This study looks at whether adjusting deep brain stimulation (DBS) can improve how you see and move. DBS uses a device implanted in your brain to help control Parkinson's symptoms. This research aims to find better settings for that device to improve your coordination and daily function.
Cleveland, OhioAges Any age - NCT06921980Recruiting
Cell therapy and brain function in AIHA
This trial looks at how cell therapy may affect your brain function and mood if you have autoimmune hemolytic anemia. It aims to help doctors understand the psychological changes that can happen during treatment.
Tianjin, Tianjin MunicipalityAges 18–65 - NCT05934188Recruiting
Study how gut signals relate to brain aging and diseases
This study looks at how the gut may influence the brain in normal aging and conditions like Alzheimer’s, Parkinson’s, and multiple sclerosis. It may help researchers understand new ways to measure or treat these brain changes over time.
Venice-Lido, VeniceAges 20–90
Hear when a new Brain Diseases trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for brain diseases?
- Yes. Clin2 currently lists 336 recruiting brain diseases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain diseases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain diseases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.