Clinical trials
Brain Health clinical trials
Below are recruiting brain health clinical trials, each written for real people, not researchers. We’re tracking 232 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06381674Recruiting
Wearable tech for balance rehab after concussion
This study tests whether a wearable device can help people with balance and vision problems after a mild concussion. You will use the device to guide your own exercises and help improve your recovery.
Portland, OregonAges 18–60 - NCT05854433Enrolling by invitation
Study brain structure in adults with muscle weakness
This study uses scans and other tests to understand how brain structure relates to symptoms in people with myotonic dystrophy type 1 or type 2. It may help researchers connect measurable brain changes to movement and other clinical outcomes.
Winston-Salem, North CarolinaAges 30–65 - NCT04354077Recruiting
Deep brain stimulation for opioid use disorder cravings
This trial studies whether deep brain stimulation (a device that delivers small electrical signals to the brain) can reduce cravings and improve symptoms in adults with opioid use disorder. You may be eligible if you have a long history of opioid dependence and have tried multiple treatment options without lasting success.
Pittsburgh, PennsylvaniaAges 22–65 - NCT07298902Recruiting
Non-invasive brain stimulation to help quit smoking
This study tests a new non-invasive brain stimulation technique to help long-term smokers quit. You'll receive a safe magnetic pulse to brain areas linked to cravings, and researchers track your progress.
Houston, TexasAges 20–60 - NCT03705715RecruitingPhase 1
Study brain immune-cell activity in different mental and brain conditions
This Phase 1 study looks for patterns (correlates) in how “microglial” brain immune cells become activated across different neuropsychiatric conditions and in healthy volunteers. It uses brain imaging to help researchers understand what might drive symptoms and differences between people.
Houston, TexasAges 18–80 - NCT04396873RecruitingPhase 1
PET brain scan study of inflammation markers in neurodegeneration
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
Bethesda, MarylandAges 18–99 - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT05271240RecruitingPhase 3
Targeted brain-artery drug added to standard treatment for new GBM
This Phase 3 trial tests whether delivering a cancer drug directly into brain blood vessels, along with standard radiation and temozolomide, works better than standard treatment alone in newly diagnosed glioblastoma (GBM). The goal is to improve control of the tumor while comparing side effects between the two approaches.
New York, New YorkAges 18 years+ - NCT05867472RecruitingPhase 3
Sedation plan for critically ill children on breathing machines
This Phase 3 trial tests a sedation approach using inhaled (“volatile”) anesthesia gases for children who need a ventilator. It aims to improve comfort and brain-related outcomes while they stay on the breathing machine for at least a day.
Hamilton, OntarioAges 1 month–18 years - NCT06251635Recruiting
Antipsychotics and brain insulin in women
This study looks at how a common antipsychotic medication (olanzapine) affects how the brain uses insulin in young women. It aims to understand weight gain and metabolic changes linked to these drugs.
Toronto, OntarioAges 18–35 - NCT07279740RecruitingPhase 2
Brain stimulation plus medication for apathy in dementia
This study tests if combining a type of brain stimulation (repetitive TMS) with a medication (methylphenidate, commonly used for ADHD) can improve apathy in people with dementia. If you have Alzheimer's or mixed dementia and struggle with low motivation, this trial may help you.
Toronto, OntarioAges Any age - NCT06942559Recruiting
Brain stimulation for treatment-resistant OCD
This trial tests a new type of brain stimulation (TMS) that is timed to your brain's natural rhythms, targeting a part of the brain linked to OCD. It may help people whose OCD has not improved with standard treatments.
Toronto, OntarioAges 18–65 - NCT02670161Enrolling by invitationPhase 4
Using electronic records to improve care for brain and nerve conditions
This study looks at how doctors use electronic medical records to improve treatment and care for people with certain brain and nervous system conditions. It may help because it tests practice-based approaches across neurology visits.
Evanston, IllinoisAges 18–100 - NCT07071350RecruitingPhase 2/Phase 3
Optimizing heart rate for persistent concussion symptoms in military veterans
This trial tests a treatment designed to improve heart rate variability, which may help reduce long-term concussion symptoms like headaches, dizziness, and trouble sleeping. It is for military veterans who have had a mild concussion more than a year ago and still have ongoing symptoms.
Richmond, VirginiaAges 18 years+ - NCT07167732Recruiting
CTNNB1 Syndrome Natural History Study
This study follows people with CTNNB1 syndrome over time to better understand the condition. It does not test any new treatment—just collects information to help future research.
SydneyAges Any age - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age
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Common questions
- Are there clinical trials for brain health?
- Yes. Clin2 currently lists 232 recruiting brain health studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain health trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain health trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.