Clinical trials
Brain and Central Nervous System Tumors clinical trials
Below are recruiting brain and central nervous system tumors clinical trials, each written for real people, not researchers. We’re tracking 75 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07416188RecruitingPhase 1/Phase 2
LMP744 drug for returning glioblastoma
This trial tests an experimental drug called LMP744 for people whose glioblastoma has come back. It aims to see if the drug can slow or stop tumor growth by targeting specific proteins in cancer cells.
Bethesda, MarylandAges 18–99 - NCT03328078RecruitingPhase 1/Phase 2
Emavusertib for recurrent brain lymphoma after prior treatment
This Phase 1/2 trial tests emavusertib (a targeted medicine) in adults with primary central nervous system lymphoma that has come back or not responded to treatment. It’s designed to find safe dosing and see how well the treatment can control the lymphoma in the brain/spinal fluid.
Phoenix, ArizonaAges 18 years+ - NCT07390539RecruitingPhase 1
CAR T cells targeting B7-H3 for brain tumors
This trial tests a new type of immune therapy (CAR T cells) that targets a protein called B7-H3 found on some brain tumors. It is for children and young adults with certain brain or spinal cord tumors that have come back after standard treatment, and aims to see if the treatment is safe and effective.
Boston, MassachusettsAges 2–21 - NCT07378683Recruiting
Predicting infection risk after brain or spinal tumor surgery
This study is building a tool to predict the risk of surgical site infection after brain or spinal tumor surgery. It may help you understand your personal infection risk before your procedure.
Beijing, PUMCAges Any age - NCT04692324Recruiting
Test spinal fluid tests to help identify brain tumor types
This study looks at spinal fluid (cerebrospinal fluid, or CSF) to find markers that may signal a brain or spinal tumor or related abnormal growth. If you have a suspected tumor near the CSF spaces, these results may help doctors better classify what’s going on.
Rochester, MinnesotaAges Any age - NCT06088121Recruiting
TMS with cognitive training for mild Alzheimer's dementia
This study tests a combination of brain stimulation (TMS) and cognitive training to improve memory and thinking in people with mild Alzheimer's. It may help if you are already on a stable dose of a donepezil-type medication and have a confirmed Alzheimer's diagnosis.
Incheon, Bupyeong 6(yuk)-dong, Bupyeong-guAges 60–85 - NCT07326566RecruitingPhase 2
Silevertinib and chemo for a type of glioblastoma
This trial tests a new drug, silevertinib, combined with temozolomide (a chemotherapy) for people with a newly diagnosed glioblastoma that has certain genetic markers. It aims to see if this combination works better than standard treatment for tumors with these specific features.
Birmingham, AlabamaAges 18 years+ - NCT07552233Recruiting
NK Cell Therapy for Recurrent Brain Tumors
This trial tests a new type of immune cell therapy (NK cells) for patients with malignant brain tumors that have come back or worsened despite previous treatment. The goal is to see if these specially prepared immune cells can help fight the cancer.
Beijing, Beijing MunicipalityAges 18–70 - NCT07167043Enrolling by invitation
AI assistant for reading brain CT and MRI scans
This study tests an AI system that helps doctors read brain CT and MRI scans. If you had a brain scan for possible tumors, stroke, injury, or other conditions, your data could be used to improve this tool.
BeijingAges Any age - NCT03988283RecruitingPhase 1
Personalized DNA vaccine for recurrent childhood brain tumors
This trial tests a personalized DNA vaccine made from your tumor’s DNA (neoantigens) to help your immune system fight the cancer. It is designed for children and young adults with certain recurrent or newly diagnosed brain/spine tumors, after they have had other standard treatments and tumor tissue is available for testing.
St Louis, MissouriAges Up to 25 years - NCT07143045Recruiting
Zorifertinib for lung cancer that has spread to the brain
This trial tracks how well zorifertinib works as a first treatment for people with a specific type of advanced lung cancer that has spread to the brain or spinal cord lining. Participants may receive zorifertinib or another standard treatment, and researchers will monitor their response over time.
Hefei, AnhuiAges 18 years+ - NCT07126821Recruiting
Brain disease diagnosis study using vision and language
This trial tests a new computer model that combines brain MRI scans and clinical data to help diagnose brain diseases. It may help doctors make more accurate diagnoses.
Changsha, HunanAges Any age - NCT07087002RecruitingPhase 1
GPC2-CAR T cells for children and young adults with relapsed medulloblastoma
This trial tests a new type of cell therapy called GPC2-CAR T cells for children and young adults whose medulloblastoma or related brain tumor has come back or not responded to standard treatment. The goal is to see if these specially designed immune cells can find and attack the tumor.
Palo Alto, CaliforniaAges 1–30 - NCT04771520RecruitingPhase 2
Avapritinib for tumors with specific KIT or PDGFRA changes
This Phase 2 trial studies avapritinib, a targeted medicine, for people whose cancer has specific KIT or PDGFRA genetic changes. It may help shrink or slow growth of certain advanced cancers, including some brain tumors, when standard treatments have not worked or for specific glioblastoma cases.
Houston, TexasAges 18 years+ - NCT07653893Recruiting
T-DXd for breast cancer that has spread to the brain
This study is looking at how well the drug trastuzumab deruxtecan (Enhertu) works for women and men with HER2-positive breast cancer that has spread to the brain. Researchers want to see how much of the drug gets into the spinal fluid and if it helps shrink brain tumors.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06418698Recruiting
Brain artery calcium and clot removal outcomes
This study looks at whether calcium buildup in brain arteries affects how well clot removal (mechanical thrombectomy) works for stroke patients. You may be able to join if you have a large artery blockage, a CT scan was done, and you are having the clot removal procedure.
Guangzhou, GuangdongAges 18 years+ - NCT06175000RecruitingPhase 2
Maintenance obinutuzumab for central nervous system lymphoma
This trial tests whether a maintenance drug called obinutuzumab can help prevent relapse in people with primary central nervous system lymphoma (a rare lymphoma in the brain or spine) who have already responded to initial chemotherapy. It is for those who have achieved at least a partial or complete response to their first treatment.
New York, New YorkAges 18 years+ - NCT06121336Recruiting
Tracking a blood marker to measure stroke recovery
This study is looking at a protein in the blood called brain-derived tau, which may increase after a stroke. By measuring it over time, doctors hope to learn more about how the brain is healing and possibly predict recovery.
Munich, BavariaAges 18 years+ - NCT06099743Recruiting
Support program for people with brain tumors
This study tests a support program that helps people with brain tumors cope with their diagnosis and treatment. The program uses acceptance and commitment therapy, which focuses on accepting difficult emotions and committing to actions that improve well-being.
Boston, MassachusettsAges 18 years+ - NCT06026735Recruiting
Lung cancer with brain spread: a surgical study
This trial looks at people with non-small cell lung cancer that has spread to the brain or the membranes around the brain. It aims to learn more about patients who are already scheduled for brain surgery, such as removing a tumor or placing a drain.
TaipeiAges 20–90 - NCT05978557Recruiting
Brain tumor drug testing using live tissue samples
This trial uses a small piece of your brain tumor after surgery to test which drugs might work best for you. It helps doctors find the most effective treatment for your specific tumor.
Chapel Hill, North CarolinaAges Any age - NCT05681195RecruitingPhase 2
Zanubrutinib plus pemetrexed for recurrent brain lymphomas
This trial tests zanubrutinib (a targeted lymphoma medicine) together with pemetrexed (chemotherapy) for lymphoma that has come back or did not respond well in or around the brain. It may help shrink measurable lymphoma and improve control of disease after prior treatments.
Miami, FloridaAges 18 years+ - NCT05672043Recruiting
Study genetic risks in children with malignant brain tumors
This study looks at genetic (DNA/molecular) features of malignant brain tumors in children. It may help doctors better understand tumor risk patterns and guide future treatment planning.
Beijing, Beijing MunicipalityAges birth–18 years - NCT07698899RecruitingPhase 1
Study of a new treatment for childhood brain and CNS cancers
This trial tests a radioactive drug (177Lu-DTPA-Omburtamab) given directly into the fluid around the brain for children and teens with certain brain cancers or cancers that have spread to the central nervous system. It aims to see if this treatment is safe and effective for tumors that have come back or not responded to other therapies.
Basking Ridge, New JerseyAges 3–22
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Common questions
- Are there clinical trials for brain and central nervous system tumors?
- Yes. Clin2 currently lists 75 recruiting brain and central nervous system tumors studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain and central nervous system tumors trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain and central nervous system tumors trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.