Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,059 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05825027Recruiting
Sorting out risk in children with a recent concussion
This study looks at how to identify which children are at higher risk after a concussion and how they should be monitored. It may help doctors choose safer, more personalized follow-up care after a recent head injury.
Durham, North CarolinaAges 11–17 - NCT05848297Recruiting
Robotic ultrasound monitoring for severe traumatic brain injury
This trial tests whether a robotic system using a bedside ultrasound test (TCD) can safely monitor brain blood flow in adults with severe traumatic brain injury soon after the injury. It may help the care team track changes earlier and adjust treatment sooner.
Davis, CaliforniaAges 18 years+ - NCT05855252Recruiting
Study on monitoring and outcomes after moderate to severe head injury
This observational study follows adults with moderate to severe traumatic brain injury to understand care and outcomes. It collects information from the first 48 hours in the ICU and may help improve how clinicians monitor and treat patients in the critical early period.
Kogarah, New South WalesAges 18 years+ - NCT05859659Recruiting
Hope HOPE study for glioma using pathology and MRI
This study looks at glioma (a type of brain tumor) and uses brain tissue testing, MRI scans, and related measurements to better understand the disease. You may benefit by being closely assessed with MRI and study follow-up, though it’s not necessarily testing a new medicine based on the listed criteria.
Beijing, Beijing MunicipalityAges 18–90 - NCT05868928Recruiting
MRI study of brain metastasis relapse after focused radiation
This study looks at MRI scan patterns to estimate the risk of brain metastases coming back after stereotactic radiosurgery (such as Gamma Knife or CyberKnife). It mainly helps by finding imaging clues that can guide follow-up after treatment.
SeoulAges 18 years+ - NCT05885529Recruiting
Blood and CT tests after a concussion to track brain injury
This study checks whether two blood proteins (GFAP and UCH-L1) can help identify which brain spots are linked to a significant head injury after a concussion. You may be able to help by providing a blood sample and getting a CT scan as part of usual care, so doctors can better sort out injury risk.
AngersAges 18 years+ - NCT05889650Recruiting
External drainage for severe TBI brain swelling
This study tests whether placing an external drainage tube in the lower back can reduce dangerous pressure in the brain after a severe traumatic brain injury. If you meet safety and brain-scan criteria, it may help the research team understand whether this approach is safe early after injury.
Gainesville, FloridaAges 18–65 - NCT05893186RecruitingEarly Phase 1
Testing DBS settings for walking and balance in Parkinson’s
This early-phase study looks at whether adjusting deep brain stimulation (DBS) can improve posture, walking, and balance in people with Parkinson’s disease. If you already have DBS in place, the trial uses computer-based planning to try different DBS directions and settings to see what helps you most.
Minneapolis, MinnesotaAges 18–89 - NCT05897775RecruitingPhase 1
Testing a new deep brain stimulator approach for essential tremor
This Phase 1 study tests a coordinated reset deep brain stimulation program for people with essential tremor. It may help reduce tremor symptoms using a specific implanted brain-stimulation device, along with special high-strength MRI and CT imaging before and after surgery.
Minneapolis, MinnesotaAges 21 years+ - NCT05942651Recruiting
tMS for impulsivity in borderline personality disorder
This trial studies whether magnetic brain stimulation (tMS) can reduce impulsive symptoms in people with borderline personality disorder. It may help by changing how brain networks involved in impulse control work.
Bron, AURAAges 18 years+ - NCT05946083RecruitingPhase 2
Study links binge drinking, gut bacteria, and brain function
This Phase 2 study looks at how binge drinking may change gut bacteria and how your brain works. You may qualify if you’re a Portuguese-speaking student and your drinking pattern and health history match the study rules.
Braga, Gualtar, BragaAges 18–23 - NCT05947045Recruiting
Virtual reality cognitive training during brain tumor radiotherapy
This trial tests whether a computer-based cognitive training program in a virtual reality setting can help children think and learn while they are getting radiation for a brain tumor. You and a parent will decide together if it’s a good fit, and the child must be able to complete the study tasks.
Memphis, TennesseeAges 8–22 - NCT05948813RecruitingPhase 2
TY-9591 for EGFR-mutant lung cancer spread to the brain
This phase 2 trial studies TY-9591 in people with advanced non-small cell lung cancer (NSCLC) that has spread to the brain and has specific EGFR mutations. It aims to see whether the medicine can control the cancer in the brain and the rest of the body, without needing immediate brain radiation.
Beijing, Beijing MunicipalityAges 18–80 - NCT05962489Recruiting
Sleep-focused DBS therapy study for Parkinson’s disease
This study looks at a sleep-focused approach to brain stimulation (DBS) in people with Parkinson’s disease. You may be able to join if you’re planning or scheduled for specific DBS surgery at the University of Minnesota and have the needed brain imaging.
Minneapolis, MinnesotaAges 21 years+ - NCT05965947Recruiting
Telehealth nutrition coaching for adults after brain injury
This study tests whether regular, online (Zoom) nutrition sessions can help adults living with a brain injury make healthier food choices from home. It’s designed for people who can join sessions by internet and participate in decision-making.
Tuscaloosa, AlabamaAges 18 years+ - NCT05976490Recruiting
Support program for people newly diagnosed with brain cancer
This study tests a “NeuroPathways” support intervention for adults who are within 6 weeks of being diagnosed with a malignant (cancerous) brain tumor. It may help patients cope and navigate care during the early, stressful period after diagnosis.
Boston, MassachusettsAges 18 years+ - NCT05977803Recruiting
MRI study of brain radiation injury in lung cancer
This study looks at how a specific kind of MRI picture (called the CEST sequence) can help characterize radiation-related brain injury and changes in brain metastases from lung cancer. It may help doctors better interpret follow-up scans after radiation, without changing your cancer treatment.
ParisAges 18 years+ - NCT05978557Recruiting
Brain tumor drug testing using live tissue samples
This trial uses a small piece of your brain tumor after surgery to test which drugs might work best for you. It helps doctors find the most effective treatment for your specific tumor.
Chapel Hill, North CarolinaAges Any age - NCT05979064Recruiting
Belly fat graft for recurrent brain tumor
This study tests if a piece of your own belly fat (omentum) placed in the brain during tumor surgery can help fight recurrent glioblastoma. It is for people who are already scheduled for surgery to remove their brain tumor.
New York, New YorkAges 18 years+ - NCT05993364Recruiting
EFA treatment for brain injury recovery
This trial tests a treatment called EFA for people recovering from a brain injury (from trauma or stroke). It aims to help patients who are still in the early stages of recovery and can breathe on their own during the day.
Rovato, BSAges 18 years+ - NCT06016387RecruitingPhase 2
Drug combo with radiation for HER2+ breast cancer spread to spinal lining
This trial tests a combination of three targeted drugs (tucatinib, trastuzumab, and capecitabine) along with radiation to the brain or spine for people whose HER2-positive breast cancer has spread to the lining of the brain or spinal cord. The goal is to see if this treatment is safe and effective.
Ottawa, OntarioAges 18 years+ - NCT06016452RecruitingPhase 2
Chlorophyllin for brain radiation damage in glioma patients
This trial tests if chlorophyllin can help manage brain damage caused by radiation therapy in people with diffuse glioma. It may reduce symptoms or prevent them from getting worse.
Mumbai, MaharashtraAges 18–70 - NCT06032026RecruitingEarly Phase 1
Brain imaging study of tracer distribution in Parkinson's and related conditions
This study uses a special imaging tracer to see how it moves through the body and brain. It may help researchers understand brain changes in Parkinson's disease and related conditions.
Philadelphia, PennsylvaniaAges 40–80 - NCT06036147Recruiting
Concussion Recovery Program for Teens
This study tests a remote program to help teens ages 11 to 18 recover from a concussion that happened 1 to 12 months ago. You'll learn ways to manage symptoms like headaches, tiredness, or trouble focusing, all from home.
Dallas, TexasAges 11–18
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,059 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.