Clinical trials
Breast Cancer Stage I clinical trials
Below are recruiting breast cancer stage i clinical trials, each written for real people, not researchers. We’re tracking 1,194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07021911Recruiting
Combining radiation with new drugs for metastatic breast cancer
This trial is testing the safety and effectiveness of combining radiation therapy with newer cancer medications (like targeted therapy or immunotherapy) for people whose breast cancer has spread to other parts of the body (stage IV). The goal is to see if adding radiation can help control the cancer better.
Rome, ItalyAges 18 years+ - NCT07025785Recruiting
Testing for tumor DNA in blood after early-stage breast cancer surgery
This study looks for tiny bits of tumor DNA in your blood after surgery to see if it can help guide future treatment. It's for people who had surgery first (not chemotherapy before surgery) and have not seen the cancer spread.
Chapel Hill, North CarolinaAges 18 years+ - NCT07029399RecruitingPhase 1
Study of NKT5097 for advanced solid tumors
This trial tests an experimental oral drug (NKT5097) for people with advanced solid tumors that have not responded to other treatments. It may also be an option for people with a specific type of breast cancer (HR+/HER2-). The goal is to see if the drug is safe and effective.
Duarte, CaliforniaAges 18 years+ - NCT07030569Recruiting
Predicting treatment response in metastatic breast cancer
This trial studies how well CT and PET scans can predict if a certain type of breast cancer will respond to a targeted treatment. It focuses on women who had a biopsy of the liver, lung, or chest lining after the cancer spread.
MilanAges Any age - NCT07037576Recruiting
Breast reconstruction study for patients needing radiation after mastectomy
This study compares two types of breast reconstruction for women who need radiation therapy after their mastectomy: one-stage reconstruction using a permanent implant placed in front of the chest muscle, versus the standard two-stage approach where a tissue expander is used first and replaced with a permanent implant later. The goal is to see which method works better and is safer for patients who require post-mastectomy radiation.
Henan, HenanAges 18–70 - NCT07042581RecruitingPhase 4
Revaree Plus for vaginal dryness in breast cancer survivors
This trial tests a vaginal insert called Revaree Plus to see if it helps breast cancer survivors who have vaginal dryness or pain from hormone therapy. It may be a good option if you are on an aromatase inhibitor or tamoxifen and have discomfort.
Basking Ridge, New JerseyAges 18 years+ - NCT07044310RecruitingPhase 2
Probiotics for preventing bone loss during breast cancer hormone therapy
This trial tests if a probiotic supplement can help prevent bone loss in women with HR-positive breast cancer who are starting an aromatase inhibitor. You would take the probiotic daily and provide blood and stool samples to see how it affects your bone health.
Jacksonville, FloridaAges 18 years+ - NCT07054190RecruitingPhase 2
Testing Inavolisib in early-stage breast cancer with PIK3CA mutation
This trial is testing a drug called Inavolisib (a type of targeted therapy) given before surgery for people with early-stage, hormone receptor-positive, HER2-negative breast cancer that has a specific genetic change (PIK3CA mutation). The goal is to see if adding Inavolisib to standard endocrine therapy can shrink the tumor more effectively.
Los Angeles, CaliforniaAges 18 years+ - NCT07057427RecruitingPhase 3
Nab-paclitaxel vs TCbHP for HER2-positive early breast cancer
This trial compares two different drug combinations given before surgery to shrink HER2-positive breast cancer tumors. The goal is to see which combination works better and has fewer side effects.
Zhengzhou, HenanAges 18–70 - NCT07069595RecruitingPhase 2
Blood test for breast cancer survivors at risk of recurrence
This trial uses a simple blood test to look for leftover cancer DNA in people with triple-negative breast cancer who still have disease after chemotherapy and surgery. It aims to catch any early signs of the cancer coming back.
Chapel Hill, North CarolinaAges 18 years+ - NCT07071038RecruitingPhase 2
Switching medication to relieve side effects from aromatase inhibitors
This trial tests whether switching to a different aromatase inhibitor or using standard treatments works better for managing side effects in breast cancer survivors. It aims to help you stay on hormone therapy longer with fewer discomforts.
Lebanon, New HampshireAges 18 years+ - NCT07071272Recruiting
Comparing two breast imaging methods before surgery
This trial compares a special mammogram with dye (CEDM) to MRI for women already diagnosed with invasive breast cancer. The goal is to see if CEDM works as well as MRI for planning surgery, potentially offering a faster or easier option.
Verona, ItalyAges 30 years+ - NCT07071402Recruiting
Ultrasound-guided vacuum removal plus surgery for early small breast cancer
This trial tests a less invasive approach for early breast cancer. First, doctors use ultrasound to guide a vacuum device to remove the small tumor (≤2 cm). Then surgery is done. The goal is to see if this combined method works well and is safe for women with early-stage breast cancer.
Xi'an, ShaanxiAges 18–70 - NCT07076485RecruitingPhase 2
Shorter radiation after surgery for node-positive breast cancer
This trial tests shorter radiation schedules for people with breast cancer that has spread to lymph nodes or is high-risk. It aims to find a shorter course of radiation that is just as effective after surgery.
Loveland, ColoradoAges 18 years+ - NCT07095023Recruiting
Oral chemo and targeted therapy before breast cancer surgery
This trial tests a combination of an oral chemotherapy pill (paclitaxel) with two targeted antibodies (pertuzumab and trastuzumab) given before surgery for HER2-positive breast cancer. The goal is to shrink the tumor and make surgery more effective.
Beijing, Beijing MunicipalityAges 18–75 - NCT07095114Recruiting
Disappearing markers for daily breast radiation
This study tests whether small disappearing ink marks can be used to guide daily radiation treatments for breast cancer. It may help make radiation more precise and comfortable.
Detroit, MichiganAges 18 years+ - NCT07107594Recruiting
Exercise, nutrition and support program for early breast cancer
This trial tests a program combining physical exercise, psychological support and nutritional advice before chemotherapy to see if it can improve treatment response in early breast cancer patients.
BarcelonaAges 18 years+ - NCT07109817RecruitingPhase 2
Desloratadine to prevent nerve damage from taxane chemo in breast cancer
This trial tests if the allergy medicine desloratadine can prevent nerve damage (numbness, tingling, pain) caused by taxane chemotherapy in people with early-stage breast cancer. Taking desloratadine daily during chemo may help protect your nerves.
The Bronx, New YorkAges 18 years+ - NCT07111728Recruiting
Checking tumor margins during breast cancer surgery
This study tests a new imaging tool that helps surgeons see if any cancer cells are left behind during a lumpectomy. It may reduce the need for a second surgery.
Pavia, LombardyAges 18–85 - NCT07116642Recruiting
Scar placement after breast-conserving surgery for breast cancer
This study compares how different scar placements after breast-conserving surgery affect your recovery and quality of life. By joining, you help doctors learn which scar location leads to the best outcomes for patients like you.
Leeds, West YorkshireAges 18 years+ - NCT07121595RecruitingPhase 2
Personalized neck radiation for mouth cancer with sentinel node biopsy
This study tests whether a personalized approach to radiation therapy after surgery, guided by a special lymph node biopsy (sentinel node biopsy), can effectively treat mouth cancer while reducing side effects. It is for people whose cancer is on one side of the mouth and has not spread to the other side of the neck or beyond.
Ann Arbor, MichiganAges 18 years+ - NCT07140679RecruitingPhase 2
Immunotherapy after surgery for certain colon cancers
This trial tests whether the immunotherapy drug toripalimab can lower the risk of colon cancer coming back after surgery. It is for people with a specific genetic feature called mismatch repair deficiency (dMMR) in their tumor, and whose cancer was at a higher stage (stage IIB, IIC, or III).
Atlanta, GeorgiaAges 18 years+ - NCT07158021RecruitingPhase 2
Comparing two ovarian suppression drugs for breast cancer
This trial tests two hormone-blocking injections (leuprolide and goserelin) to suppress ovarian function in premenopausal women with breast cancer. It aims to see how well these drugs work when taken with standard hormone pills.
Ann Arbor, MichiganAges 18 years+ - NCT07159451RecruitingPhase 2
Elacestrant for premenopausal women with early breast cancer
This trial tests a new hormone therapy pill, elacestrant, given alone or with another drug to suppress ovarian function before surgery. It's for premenopausal women with early-stage, hormone receptor-positive, HER2-negative breast cancer to see if it can shrink the tumor.
VillejuifAges 18 years+
Hear when a new Breast Cancer Stage I trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for breast cancer stage i?
- Yes. Clin2 currently lists 1,194 recruiting breast cancer stage i studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage i trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage i trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early-stage Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.