Clinical trials
Bupivacaine clinical trials
Below are recruiting bupivacaine clinical trials, each written for real people, not researchers. We’re tracking 206 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04066296RecruitingPhase 2
Testing a numbing medicine to improve back decompression outcomes
This Phase 2 study looks at whether a long-lasting local pain medicine (liposomal bupivacaine) can improve recovery and outcomes after surgery for lumbar stenosis (narrowing in the lower spine). You may be considered if you’re an adult needing decompression surgery and do not have reasons that would make surgery unsafe or different from the study’s plan.
Aurora, ColoradoAges 18 years+ - NCT04209504Recruiting
Nerve block study for one-sided breathing muscle weakness after shoulder surgery
This trial tests whether a longer-lasting nerve block during shoulder surgery can better manage pain and affect one-sided diaphragm (breathing muscle) weakness. It may help people having planned (first-time) shoulder surgery who are able to follow study pain-checks.
Durham, North CarolinaAges 18–80 - NCT04640896RecruitingPhase 4
Trigger point injections during planned neck surgery
This trial studies whether adding “trigger point” numbing shots to sore neck muscles during planned neck surgery is safe and helpful. It may help reduce pain or improve comfort after surgery.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07698665Recruiting
Ketamine vs dexmedetomidine in scalp block for brain tumor surgery
This trial compares two medicines, ketamine and dexmedetomidine, added to a scalp nerve block during brain tumor removal surgery. The goal is to see which provides better pain control and recovery after surgery.
Cairo, GovernorateAges 20–60 - NCT07640516Recruiting
Pain Relief Comparison for Amputation Surgery in High-Risk Patients
This study compares two medications (dexmedetomidine and fentanyl) mixed with a numbing agent to see which works better for blocking pain during above-knee amputation surgery in patients with serious heart or lung disease. Both drugs are already used in anesthesia, and this trial tests which combination is safest and most effective for you.
CairoAges 18 years+ - NCT06809998RecruitingPhase 1/Phase 2
Steroid injection in non-surgical knee before knee replacement
This study tests whether a single steroid injection in the healthy knee (the one not being replaced) can reduce pain and improve recovery after total knee replacement. It may help people who have arthritis in both knees but are only having one replaced now.
Toronto, OntarioAges 18 years+ - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT05029726RecruitingPhase 4
Numbing medicine during back surgery to reduce pain
This trial tests a regional anesthesia (numbing medicine given near nerves) during minimally invasive lumbar spine surgery. The goal is to see if it helps control pain around surgery and improves recovery comfort.
Chicago, IllinoisAges 18–80 - NCT05131178Recruiting
Study for pain control after C-section
This trial looks at how to reduce pain after a C-section (cesarean delivery). You may be able to join if you’re having a scheduled or urgent C-section and can use the planned pain-control method.
Aurora, ColoradoAges 18–50 - NCT05193227RecruitingPhase 2
Slow-release lidocaine patch for pain after pelvic surgery
This Phase 2 study tests a slow-release form of lidocaine to reduce pain after surgery that uses a pelvic incision. If you’re having a qualifying pelvic operation, the study may help see whether this medication improves postoperative pain control.
Vancouver, British ColumbiaAges 19 years+ - NCT05216770RecruitingEarly Phase 1
Brain-scan study of voice dystonia and tremor
This early study uses brain and voice-related testing to better understand what is happening in the brain in people with laryngeal dystonia or voice tremor. The results may help scientists learn more about these conditions and how they differ from healthy voices.
Boston, MassachusettsAges 18–80 - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+ - NCT05793060RecruitingPhase 4
Compare two add-on medicines for neck nerve block comfort
This study compares dexmedetomidine versus dexamethasone as “extra” medicines added to bupivacaine during an intermediate cervical plexus nerve block. It aims to see which add-on helps with pain control and smoother comfort after the procedure.
Damanhūr, El-BeheiraAges 21–60 - NCT05906433RecruitingPhase 1
Best type of numbing medicine for knee steroid shots
This early (Phase 1) study looks at which anesthetic (numbing medicine) works best and is safest during steroid injections for knee osteoarthritis. It may help improve comfort and effectiveness of these common pain-relief shots.
Tampa, FloridaAges 18 years+ - NCT05979493RecruitingPhase 4
Nerve block for pain after fibroid surgery
This study tests whether a nerve block (QL block) can help with pain after surgery to remove uterine fibroids while keeping the uterus. It may be a good option if you are having a laparoscopic myomectomy and want to manage pain without strong opioids.
Beachwood, OhioAges 18–45 - NCT05996133RecruitingPhase 4
Neck Numbing Shot vs. Sham for Neck Surgery Pain
This trial tests whether a numbing injection (called a multifidus cervicis plane block) in the neck muscles helps reduce pain after back-of-the-neck fusion surgery. Half the participants will get the real block, the other half a sham (fake) block, to see if it really works.
Hartford, ConnecticutAges 40–80 - NCT06069791RecruitingPhase 1
Nerve block study for veterans with post-concussion headaches
This study tests a nerve block injection (a numbing medicine) in the back of the head to see if it helps veterans with long-term headaches after a concussion. You might join if you have had frequent headaches for at least three months after a head injury.
West Haven, ConnecticutAges 18 years+ - NCT06166628Recruiting
Comparing two procedures for knee osteoarthritis pain
This study compares two minimally invasive procedures—embolization (blocking blood flow) and nerve ablation (blocking pain signals)—to see which works better for knee osteoarthritis pain. If you have long-lasting knee pain and are considering knee replacement surgery, this trial may help find another option.
Kingston, OntarioAges 40 years+ - NCT06189781RecruitingPhase 4
Pain shot vs epidural for hip surgery in kids with cerebral palsy
This study compares a pain injection to epidural anesthesia for children with cerebral palsy having hip surgery. The goal is to see which method provides better pain control during and after the procedure.
Los Angeles, CaliforniaAges Up to 18 years - NCT06270147RecruitingPhase 2
Timing of nerve blocks for weight loss surgery pain
This trial tests whether giving a nerve block before or after bariatric surgery works better for pain control. It could help you have less pain and use fewer painkillers after your procedure.
Hamilton, OntarioAges 18 years+ - NCT06271265RecruitingPhase 1
Testing EXPAREL for pain after heart surgery in children
This study tests a long-acting pain medicine (EXPAREL) given during heart surgery to see how it works in young children. The goal is to help control pain after surgery with fewer side effects.
Indianapolis, IndianaAges birth–6 years - NCT06338865Recruiting
Lower pressure vs. standard pressure for laparoscopic gynecologic surgery
This trial compares using lower gas pressure during minimally invasive gynecologic surgery to the standard pressure. The goal is to see if lower pressure reduces pain and speeds recovery after surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT06349668RecruitingPhase 3
Comparing spinal morphine and IV lidocaine for robotic kidney surgery
This trial compares two ways to manage pain during robotic-assisted kidney or ureter surgery: a spinal injection of morphine or an intravenous infusion of lidocaine. The goal is to see which method provides better pain relief and recovery.
KalmarAges 18 years+ - NCT06353529RecruitingPhase 4
Pain management after pituitary tumor surgery
This study tests a nerve block (called sphenopalatine ganglion block) for pain relief after pituitary tumor surgery through the nose. It aims to see if this block helps manage pain and reduces the need for other pain medicines.
Hamilton, OntarioAges 18–100
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Common questions
- Are there clinical trials for bupivacaine?
- Yes. Clin2 currently lists 206 recruiting bupivacaine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bupivacaine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bupivacaine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.