Clinical trials · Philadelphia, PA
Cancer clinical trials in Philadelphia
We’re tracking 622 recruiting cancer studies with a site in or near Philadelphia — including Phase 1, Phase 1/Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Philadelphia
- NCT03678025RecruitingPhase 3
Standard treatment for metastatic prostate cancer, with or without local treatment
This Phase 3 trial studies whether using the usual medicines for metastatic prostate cancer, plus a definitive local treatment to the prostate, improves outcomes. It may help determine if treating the prostate directly can benefit people whose cancer has not worsened after initial hormone-based treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06578637Recruiting
BHB supplement study for familial adenomatous polyposis
This trial tests whether taking a supplement called beta-hydroxybutyrate (BHB) can help prevent polyps in people with familial adenomatous polyposis (FAP), a condition that causes many polyps in the colon. The study has two parts: one for people who have already had colon surgery, and another for those who still have their colon.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07174583RecruitingPhase 1/Phase 2
Study of IDE849 for DLL3-positive cancers like SCLC
This trial tests a new drug called IDE849 for cancers that make a protein called DLL3, including small cell lung cancer and some neuroendocrine tumors. It is for people whose cancer has progressed after standard treatments, and may be given alone or combined with other drugs like durvalumab or IDE161.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06416150Recruiting
Text message support for cervical cancer screening
This study aims to reduce gaps in cervical cancer care by using text messages to help people who have been referred for a colposcopy. If you qualify, you will receive text reminders and support to make sure you get the follow-up you need.
Philadelphia, PennsylvaniaAges 18–90 - NCT06904339Recruiting
Sexual health communication during gynecologic cancer care
This trial looks at ways to improve how doctors and patients talk about sexual health concerns during and after gynecologic cancer treatment. You might be able to join if you are currently or have recently been treated for gynecologic cancer and have some sexual health concerns.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06510374RecruitingPhase 3
Gene therapy vs. observation for intermediate risk bladder cancer
This trial tests a new gene therapy called nadofaragene firadenovec versus just watching and waiting (observation) for people with a specific type of bladder cancer that hasn't grown into the muscle. The goal is to see if the gene therapy can help keep the cancer from coming back.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05125016RecruitingPhase 1/Phase 2
Study drug for advanced prostate cancer after standard treatments
This early-phase study tests whether REGN4336 is safe and how well it works, by itself or with REGN5678, in adults with advanced prostate cancer. It may help people whose cancer has continued to worsen despite standard prostate cancer medicines.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05880667RecruitingPhase 1
Adaptive focused radiation for belly and pelvic cancer spread
This Phase 1 study tests an “adaptive” form of focused radiation (SBRT) for cancers that have spread in the abdomen or pelvis. It aims to treat metastatic tumor spots safely while adjusting the plan as needed during treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07052214RecruitingPhase 3
PSMA PET plus MRI to find prostate cancer
This trial tests if combining a PSMA PET scan with an MRI can better detect clinically significant prostate cancer than MRI alone. It may help men who have not had a prostate biopsy before and have certain risk factors.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06933758Recruiting
Temple Health Chest Lung Screening Study
This study looks at how a hospital program can help people who are at risk for lung cancer get the proper screening and follow-up care. You may be eligible if you are a Temple patient and have had a low-dose CT scan for lung cancer screening.
Philadelphia, PennsylvaniaAges 50–80 - NCT06545955RecruitingPhase 3
Gene therapy study for high-grade bladder cancer not responding to BCG
This trial tests a gene therapy called nadofaragene firadenovec, given directly into the bladder, either alone or with chemo or immunotherapy. It's for people with high-grade bladder cancer that hasn't gone away after BCG treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07147179Recruiting
Short course radiation for brain tumors in children
This trial tests a short course of radiation (fewer sessions) to help control symptoms from cancer that has spread to the brain or come back in the brain. It is for children and young adults whose cancer cannot be cured, and who are able to do some daily activities.
Philadelphia, PennsylvaniaAges Up to 21 years - NCT06967467Enrolling by invitation
Testing Penicillin Allergies in Blood Cancer Patients
This study tests if an antibiotic allergy evaluation can help improve treatment for people with blood cancers. It aims to safely remove inaccurate penicillin allergy labels, potentially allowing use of better antibiotics.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06984562Recruiting
Adaptive radiation therapy for advanced pancreatic cancer
This trial tests a new way of giving radiation therapy that adapts to changes in your cancer over time. It is for people with pancreatic cancer that cannot be removed by surgery but has not spread to other parts of the body.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07478848RecruitingPhase 1
Radiation, Vancomycin, and CAR-T for B-cell lymphoma
This trial tests whether giving radiation and an oral antibiotic (vancomycin) before CAR-T therapy helps treat B-cell lymphoma more effectively. It is for people who are already scheduled to receive CAR-T treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07454499Recruiting
Symptom monitoring and health for women on hormone therapy for breast cancer
This trial tests a mobile health program to help women manage symptoms and stay healthy while taking hormone therapy (like tamoxifen or anastrozole) for early-stage breast cancer. It involves using a smartphone app and an electronic pill bottle to track your health and medication.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06592924RecruitingPhase 3
Adding chemo to hormone therapy for prostate cancer with slow PSA drop
This trial tests if adding docetaxel chemotherapy helps men whose PSA hasn't dropped enough after at least 6 months of standard hormone therapy (ADT) plus an ARPI pill (like abiraterone or enzalutamide) for metastatic prostate cancer that still responds to hormones.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05746104Enrolling by invitationPhase 1
Testing a glowing dye to find nervous system tumor tissue
This early (Phase 1) study tests whether a glowing dye called indocyanine green helps surgeons better see nervous system tumor tissue during an operation, with the goal of lowering the chance of tumor coming back locally. It’s for adults whose tumor is expected to be removable and at risk for local recurrence.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07458347RecruitingPhase 1
A new oral drug for KRAS-mutated advanced cancer
This trial tests a new oral drug, KST-6051, for people with advanced solid tumors (like lung, pancreatic, colon, or other cancers) that have a specific KRAS gene mutation. The goal is to find the best dose and see if it's safe.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05614739RecruitingPhase 1
Study of vepugratinib for cancers with FGFR3 gene changes
This study tests a new pill, vepugratinib, for people whose cancer has a specific change in a gene called FGFR3. The drug targets this gene change to try to slow or shrink the cancer, and may be an option if standard treatments have not worked.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06463262Recruiting
Personalized markers for chordoma before surgery and radiation
This trial tests whether analyzing blood and tumor samples before and after radiation and surgery can help find personalized markers for chordoma. It is for patients with chordoma of the skull base, spine, or sacrum who will receive radiation before surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07213804RecruitingPhase 3
Study of sofetabart mipitecan for ovarian cancer
This trial tests a new drug called sofetabart mipitecan for people with ovarian cancer that has come back after treatment. It is for those whose cancer is either resistant to platinum chemo (Part A) or sensitive to it (Parts B and C). The study will see if the drug can help shrink or slow the cancer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05335928RecruitingPhase 3
Abatacept for immune-therapy heart inflammation in hospitalized adults
This Phase 3 trial tests abatacept to treat myocarditis (inflammation of the heart muscle) caused by immune checkpoint cancer medicines. It may help patients recover faster and safely manage this serious side effect while they are in the hospital.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06498635RecruitingPhase 3
Immunotherapy after surgery for lung cancer with no remaining cancer
This trial tests whether giving immunotherapy (durvalumab) after surgery can help prevent lung cancer from coming back if you already had a complete response to chemo and immunotherapy before surgery. It is for people with early-stage non-small cell lung cancer who had no cancer left after treatment.
Philadelphia, PennsylvaniaAges 18 years+
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Cancer trials in other cities
Where these studies are running near Philadelphia
Institutions with a site for the recruiting cancer studies listed above.
- University of Pennsylvania · 12 studies
- Thomas Jefferson University Hospital · 6 studies
- Fox Chase Cancer Center · 5 studies
- Helen F Graham Cancer Center · 3 studies
- MidLantic Urology · 3 studies
- Christiana Care Health System-Christiana Hospital · 2 studies
- Medical Oncology Hematology Consultants PA · 2 studies
- Temple University Hospital · 2 studies
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting cancer studies in Pennsylvania.
Common questions
- Are there cancer clinical trials near Philadelphia?
- Yes. We're currently tracking 622 recruiting cancer studies with a site near Philadelphia, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study near Philadelphia?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Philadelphia to take part?
- Not necessarily. These studies have a site near Philadelphia, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open near Philadelphia regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.