Clinical trials · North Carolina
Cancer clinical trials in North Carolina
We’re tracking 618 recruiting cancer studies with a site in North Carolina — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT07144228Recruiting
Platelet test for finding and tracking prostate cancer
This trial studies a new blood test that looks at platelets (a part of your blood) to help find prostate cancer or keep track of it. You may join if you are a man over 40 with a suspicion of prostate cancer who has not been treated for it before.
Durham, North CarolinaAges 40 years+ - NCT07190300RecruitingPhase 1/Phase 2
Testing tulmimetostat with hormone therapy for metastatic prostate cancer
This trial tests a new drug, tulmimetostat, combined with standard hormone therapies like darolutamide or abiraterone for men with metastatic prostate cancer that still responds to hormone treatment. The goal is to see if the combination works better than standard therapy alone.
Durham, North CarolinaAges 18 years+ - NCT07225114RecruitingPhase 2
Better ultrasound imaging with contrast before biopsy
This trial tests a new, detailed ultrasound technique that uses a contrast agent (called Definity) to get clearer images of a suspicious area before a biopsy. It may help doctors better see the blood flow in the lesion, which could improve diagnosis.
Chapel Hill, North CarolinaAges 18 years+ - NCT06819007RecruitingPhase 3
Study of trastuzumab deruxtecan plus bevacizumab for HER2-positive ovarian cancer
This trial tests whether adding trastuzumab deruxtecan to standard maintenance therapy with bevacizumab works better than bevacizumab alone for people with advanced ovarian cancer that has the HER2 protein. It is for those who have finished initial chemotherapy plus bevacizumab and are now starting maintenance treatment.
Chapel Hill, North CarolinaAges 18 years+ - NCT07091617Recruiting
Better genetic testing for young adults with cancer
This study tests a new way to offer genetic testing to young adults (ages 18-39) who have or had cancer. The goal is to make it easier for you to learn if you have inherited gene changes that could affect your cancer and your family's health.
Charlotte, North CarolinaAges 18 years+ - NCT07278557RecruitingPhase 2
MRI-guided radiation to reduce dry mouth from head and neck cancer treatment
This trial tests if using an MRI to map saliva glands before radiation can help spare them, reducing dry mouth. It is for people with oropharynx cancer who will receive radiation with or without chemotherapy.
Chapel Hill, North CarolinaAges 18 years+ - NCT07292818RecruitingPhase 1
Hyaluronic acid gel spacer study for cervical cancer radiation
This trial tests if a gel spacer made from hyaluronic acid can protect healthy tissue during radiation for cervical cancer. It may help reduce side effects for patients getting chemoradiotherapy with brachytherapy.
Chapel Hill, North CarolinaAges 18 years+ - NCT07317505RecruitingPhase 1
Study of JMT108 for Advanced Solid Tumors
This trial tests a new drug called JMT108 in people with advanced solid tumors that have not responded to standard treatments or for which no standard treatment exists. The study aims to see if the drug is safe and how it affects the body.
Huntersville, North CarolinaAges 18 years+ - NCT07322367Recruiting
Mobile program to help you get screened for lung cancer
This study tests a mobile health program to remind and assist you in getting a lung cancer screening scan if you are at high risk. The goal is to make it easier to follow screening guidelines.
Winston-Salem, North CarolinaAges 50–77 - NCT07335354Recruiting
Decision tool for breast reconstruction after mastectomy
This study is testing a decision tool to help people who are thinking about breast reconstruction surgery after a mastectomy. The tool is designed to help you and your doctor make a more informed choice.
Durham, North CarolinaAges 18 years+ - NCT05128825RecruitingPhase 2
Test drug azenosertib for platinum-resistant ovarian cancer
This Phase 2 trial tests azenosertib to treat platinum-resistant high-grade serous ovarian, fallopian tube, or primary peritoneal cancer. It looks for whether the drug can shrink tumors and improve outcomes in people whose cancer has returned after platinum chemotherapy.
Durham, North CarolinaAges 18 years+ - NCT04804644RecruitingPhase 3
Memory-sparing radiation for brain metastases in small cell lung cancer
This study tests whether focusing high-dose radiation only on brain tumor spots, while avoiding the hippocampus (a brain area important for memory), helps protect memory and thinking compared with standard whole-brain radiation. It’s for people with small cell lung cancer that has spread to the brain.
Winston-Salem, North CarolinaAges 18 years+ - NCT07431281RecruitingPhase 3
New drug combo for advanced stomach cancer with CLDN18.2
This trial tests a new drug combination for people with advanced stomach cancer that has not been treated before. It looks at two groups: one with PD-L1 (a protein that helps decide if immunotherapy works), and one without. The treatment includes an antibody-drug conjugate (Sonesitatug Vedotin) plus standard chemotherapy, with or without an immunotherapy drug.
Wilmington, North CarolinaAges 18 years+ - NCT07396766Recruiting
BREASTChoice decision aid for breast surgery patients
This study tests a tool called BREASTChoice AIM1-B, which helps people who have had breast surgery make informed choices about their follow-up care. You may be eligible if you had a mastectomy or lumpectomy in the past 8 years for breast cancer or to lower your risk.
Chapel Hill, North CarolinaAges 18 years+ - NCT00843375Recruiting
Testing stool samples to find early colon cancer and polyps
This study checks stool samples to see how well stool tests can detect early colon cancer and precancerous growths called adenomas. If you qualify, you’ll collect stool samples for a lab test (FIT) and sometimes this helps sort who should get follow-up testing.
Chapel Hill, North CarolinaAges 18 years+ - NCT01137825Recruiting
Older patient cancer registry for a health check
This study is a registry that collects information from older adults who may be dealing with cancer. It includes a short health and function check to help doctors understand needs and guide care, even for people who turn out not to have cancer.
Hendersonville, North CarolinaAges 65 years+ - NCT01137643Recruiting
Sharing blood and tissue samples for blood cancer research
This trial collects tissue, blood, and other body fluid samples from people with blood-related cancers. The goal is to help researchers study these diseases by building a source of samples for future testing.
Chapel Hill, North CarolinaAges 18–120 - NCT00900575Recruiting
Test optical scans to detect cervical cancer during care
This study tests whether special light-based scans (optical spectroscopy) can help detect cervical cancer. It may be done around colposcopy, and participants may also be monitored with follow-up Pap smears after treatment.
Durham, North CarolinaAges 18 years+ - NCT01109394Recruiting
Help study tumors with sample testing and a research biology library
This study collects tumor (or related) samples to analyze their genes and build a shared research “biobank.” It may help researchers understand cancers better for future diagnosis and treatments.
Charlotte, North CarolinaAges 4 weeks+ - NCT02474160Recruiting
Banking cancer tissue and blood for future research
This study collects and stores leftover or newly taken samples of tissue and blood from people with cancer. The goal is to build a research library that can help investigators study cancer and develop better tests or treatments.
Chapel Hill, North CarolinaAges 2 months+ - NCT02422641RecruitingPhase 2
High-dose methotrexate for breast cancer in the brain lining
This Phase 2 trial tests whether giving high-dose methotrexate into the bloodstream can help treat breast cancer that has spread to the thin lining covering the brain and spinal cord. It may help reduce cancer in the leptomeningeal (brain-lining) area and control symptoms.
Winston-Salem, North CarolinaAges 18 years+ - NCT02468024RecruitingPhase 3
Surgery or focused radiation for early lung cancer
This study compares two treatments—removing only part of the lung (sublobar resection) versus a focused radiation approach (stereotactic ablative radiotherapy)—for early-stage non-small cell lung cancer. It aims to see which option works better with fewer problems for the right patients.
Winston-Salem, North CarolinaAges 18 years+ - NCT02427269Enrolling by invitation
Blood and tissue sample study for esophagus conditions
This study collects blood and biopsy tissue from people who are having an upper endoscopy at UNC for Barrett’s esophagus or esophageal cancer. The samples help researchers build a biorepository to study these conditions and support future research.
Chapel Hill, North CarolinaAges 18 years+ - NCT07470853RecruitingPhase 1
Study of HWK-016 for advanced ovarian or endometrial cancer
This trial tests a new drug called HWK-016, which is designed to target and deliver medicine directly to cancer cells that have a specific marker (MUC16). It is for people with advanced ovarian or endometrial cancer to see if it can shrink tumors or slow their growth.
Charlotte, North CarolinaAges 18 years+
Cancer trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting cancer studies listed above.
- University of North Carolina at Chapel Hill · 7 studies
- UNC Lineberger Comprehensive Cancer Center · 4 studies
- Duke University Medical Center · 3 studies
- Atrium Health Wake Forest Baptist Medical Center (Wake Forest Baptist) · 2 studies
- Wake Forest University Health Sciences · 2 studies
- Atrium Health Wake Forest Baptist
- Carolina BioOncology Institute
- Carolina East Health System
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cancer trials in other states
Common questions
- Are there cancer clinical trials in North Carolina?
- Yes. We're currently tracking 618 recruiting cancer studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.