Clinical trials · Ohio
Cancer clinical trials in Ohio
We’re tracking 788 recruiting cancer studies with a site in Ohio — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Ohio
- NCT06463028RecruitingPhase 2
Targeted pills plus chemo for advanced endometrial cancer
This trial tests a combination of two targeted pills (sapanisertib and serabelisib) with standard chemo (paclitaxel) for endometrial cancer that has come back or spread. A substudy also looks at combining these drugs with a special diet that lowers insulin levels.
Cincinnati, OhioAges 18 years+ - NCT03972657RecruitingPhase 1/Phase 2
Testing a new prostate and kidney cancer drug with immunotherapy
This early trial tests whether REGN5678 (nezastomig) is safe and how well it works, either by itself or with an immunotherapy drug (cemiplimab). It targets adults with metastatic castration-resistant prostate cancer and certain metastatic kidney cancers that have already been treated.
Columbus, OhioAges 18 years+ - NCT04613596RecruitingPhase 2/Phase 3
Adagrasib for KRAS G12C lung cancer, alone or with pembrolizumab
This trial studies adagrasib (an anti-cancer drug) either alone or with pembrolizumab (an immunotherapy) in people with advanced lung cancer that has a KRAS G12C mutation. It aims to shrink tumors and improve outcomes, including for people without urgent brain treatment needs.
Cincinnati, OhioAges 18 years+ - NCT06486454Recruiting
Liver tumor treatment with sound waves
This trial tests a new device that uses sound waves to destroy liver tumors without cutting or needles. It may be an option if you have a liver tumor that can be partly or fully targeted by this technique.
Cleveland, OhioAges 22 years+ - NCT06500481RecruitingPhase 3
Proton vs standard radiation for cancer spread to brain/spine lining
This trial compares a newer type of radiation (proton therapy) to standard radiation for people whose breast or lung cancer has spread to the lining of the brain and spinal cord. It aims to see if proton therapy can better control the disease while causing fewer side effects.
Columbus, OhioAges 18 years+ - NCT06527157Recruiting
Study on reproductive cancers in women
This study is looking at women who have unusual bleeding or bleeding after menopause to find better ways to diagnose reproductive cancers like endometrial cancer. If you are 45 or older and still have your uterus, you may be able to help.
Akron, OhioAges 45–100 - NCT06548672RecruitingPhase 1
Study of BC3195 for advanced or metastatic cancer
This trial tests a new drug called BC3195 in people with advanced or metastatic solid tumors that have not responded to or cannot tolerate standard treatments. It aims to see if the drug is safe and effective for cancers that express a specific marker called CDH3.
Cleveland, OhioAges 18 years+ - NCT06562543RecruitingPhase 4
Fruquintinib for advanced colorectal cancer in minority populations
This trial tests a medication called fruquintinib (an oral pill) for people with advanced colorectal cancer that has not responded to prior treatments. It is specifically looking for participants who identify as Black or African American and/or Hispanic or Latino to help understand how the drug works in these groups.
Columbus, OhioAges 18 years+ - NCT06574880RecruitingPhase 1/Phase 2
Radiation and Lutetium PSMA for locally advanced prostate cancer
This study tests a combination of focused radiation (SBRT) and a targeted radioactive drug (Lutetium PSMA) for men with prostate cancer that has spread to nearby lymph nodes or has high-risk features but has not yet reached distant organs. The goal is to see if this approach is safe and effective.
Cleveland, OhioAges 18 years+ - NCT06586515RecruitingPhase 1
Testing a new drug for cancers with KRAS G12D mutation
This trial tests a new pill (LY3962673) for people whose cancer has a specific DNA change called KRAS G12D. The drug aims to block the faulty protein that helps the cancer grow, and the study will look at safety and whether the tumor shrinks.
Cincinnati, OhioAges 18 years+ - NCT06592638RecruitingPhase 1
ZG006 for small cell lung cancer
This trial tests a new drug called ZG006 for people with small cell lung cancer that has not responded to or can no longer tolerate standard treatments. The goal is to find the best dose and see if it can help shrink or control the cancer.
Canton, OhioAges 18–75 - NCT06139627Recruiting
Geriatric assessment for older adults with lung cancer getting chemotherapy and radiation
This trial tests whether a special geriatric assessment can help manage side effects for adults aged 60 and older with non-small cell lung cancer who are starting a new treatment plan that includes chemotherapy and radiation. It aims to improve quality of life and treatment outcomes.
Columbus, OhioAges 60 years+ - NCT06616623RecruitingPhase 1
Vismodegib and Atezolizumab for advanced lung cancer
This trial tests a combination of two drugs, vismodegib and atezolizumab, for people with non-small cell lung cancer that has spread or come back after standard treatments. The goal is to see if this new combination can help shrink tumors or slow the cancer's growth.
Columbus, OhioAges 18 years+ - NCT06643884RecruitingPhase 2
Study of eye injection for cancer that spread to the choroid
This trial tests a new way to deliver treatment directly into the eye (through a thin space near the choroid) for people whose cancer has spread to the eye. It aims to see if this targeted approach can safely shrink the eye tumors.
Cleveland, OhioAges 18 years+ - NCT06646276RecruitingPhase 3
New drug combo vs standard care for first-line extensive-stage small cell lung cancer
This trial tests a new combination of drugs (BMS-986489 with chemotherapy) against the current standard treatment (atezolizumab with chemotherapy) for people who have just been diagnosed with extensive-stage small cell lung cancer. It aims to see which approach works better and is safer.
Cincinnati, OhioAges 18 years+ - NCT06651580Recruiting
Gene study for kids with pancreas problems
This study collects samples like blood or tissue from children with pancreatitis to look for gene changes that might raise their risk. It helps doctors learn more about why some children get pancreas inflammation.
Columbus, OhioAges Up to 17 years - NCT06666192Recruiting
OSU Community Cancer Screening Program
This program aims to make cancer screening easier for people in certain neighborhoods near Ohio State University clinics. It works with clinics, healthcare providers, and patients to improve access to preventive care.
Columbus, OhioAges Any age - NCT06535607RecruitingPhase 2
Study of volrustomig for advanced solid tumors
This trial tests a new drug called volrustomig, alone or with other cancer treatments, for people with advanced or metastatic solid tumors. It aims to see if the drug can help shrink or control the cancer.
Columbus, OhioAges 18 years+ - NCT07281430Recruiting
HPV self-test for cervical cancer screening
This study tests if a self-collected sample for HPV testing works as well as standard colposcopy to prevent cervical cancer. If you've recently had an abnormal cervical cancer screening and need a colposcopy, this trial may be an option for you.
Cincinnati, OhioAges 25 years+ - NCT07406282Recruiting
Darolutamide for new prostate cancer that spread
This study looks at how well darolutamide and similar drugs work for men whose prostate cancer has just spread to other parts of the body. It aims to understand real-world outcomes in urology clinics.
Cleveland, OhioAges 18 years+ - NCT06749210RecruitingPhase 2
Balance training for nerve damage from chemotherapy
This trial tests a special exercise program (called balance training) to help breast cancer survivors who still have nerve damage and balance problems after finishing taxane chemotherapy. If you have tingling, numbness, or trouble staying steady, this study may help improve your balance and reduce fall risk.
Columbus, OhioAges 40 years+ - NCT06757634RecruitingPhase 3
A study of gedatolisib for first-line advanced breast cancer
This trial tests a new targeted therapy called gedatolisib for people with HR-positive, HER2-negative advanced breast cancer who have not yet received treatment for metastatic disease. It aims to see if adding this drug to standard hormone therapy can help control the cancer longer.
Columbus, OhioAges 18 years+ - NCT06769126RecruitingPhase 2
Personalized treatment study for extensive stage small cell lung cancer
This study uses biomarker tests on your tumor to find a personalized treatment after initial chemotherapy. You will be assigned to one of four treatment groups based on your biomarker results.
Canton, OhioAges 18 years+ - NCT06769334Recruiting
School readiness program for young cancer survivors
This study helps young childhood cancer survivors (ages 3 to 6) get ready for school and daily life. It works with both the child's caregiver and teacher to provide support and resources.
Columbus, OhioAges Any age
Cancer trials by city in Ohio
Where these studies are running in Ohio
Institutions with a site for the recruiting cancer studies listed above.
- The Ohio State University Wexner Medical Center · 8 studies
- Cleveland Clinic · 3 studies
- Miami Valley Hospital South · 2 studies
- Nationwide Children's Hospital · 2 studies
- Oncology Hematology Care · 2 studies
- University Hospitals Cleveland Medical Center · 2 studies
- University of Cincinnati Cancer Center-UC Medical Center · 2 studies
- Atrium Medical Center
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cancer trials in other states
Common questions
- Are there cancer clinical trials in Ohio?
- Yes. We're currently tracking 788 recruiting cancer studies with a site in Ohio, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study in Ohio?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Ohio to take part?
- Not necessarily. These studies have a site in Ohio, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open in Ohio regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.