Clinical trials
Cannabis Use Disorder clinical trials
Below are recruiting cannabis use disorder clinical trials, each written for real people, not researchers. We’re tracking 150 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07218354RecruitingPhase 3
Study of semaglutide to help veterans drink less alcohol
This study tests whether a weekly medicine called semaglutide can help veterans who drink heavily reduce their alcohol intake. If you're a veteran and want to cut down on drinking, this study may be an option.
Long Beach, CaliforniaAges 18–80 - NCT06941298Recruiting
Cannabis and depression study for teens and young adults
This study looks at how cannabis affects the brain and mood in teens and young adults. It compares people who use cannabis, people with depression who don't use cannabis, and healthy volunteers to understand links between cannabis use and mental health.
Miami, FloridaAges 14–20 - NCT06796062RecruitingPhase 2
Psilocybin for opioid use disorder
This study tests whether psilocybin can help people who want to stop using opioids and are already in treatment. Eligible participants receive a single dose of psilocybin in a supervised setting and are followed to see if it reduces opioid use.
Albuquerque, New MexicoAges 18–65 - NCT06648642Recruiting
MRI-guided brain stimulation for alcohol use disorder
This study tests whether a new type of brain stimulation, guided by MRI and a robot, can help reduce heavy drinking in people with alcohol use disorder. The treatment is non-invasive and aims to improve brain function related to cravings.
San Antonio, TexasAges 18–65 - NCT05934305Recruiting
Help for shame and stigma in HIV and substance use
This study tests whether a program can reduce shame and stigma for people living with HIV who also have a substance use disorder. It may help you feel less judged and cope better, while supporting HIV care.
Miami, FloridaAges 18 years+ - NCT07459270Recruiting
Psychotic symptoms in methamphetamine users with and without cannabis
This study compares people who have psychosis from methamphetamine and also use cannabis with those who only have methamphetamine-induced psychosis. It aims to understand how cannabis may affect their symptoms.
Elâzığ, ElâzığAges 18–65 - NCT05913752RecruitingPhase 1/Phase 2
Test drug CMND-100 in people with alcohol use disorder
This early study tests the safety and dosing of CMND-100 in first-time participants, including people with alcohol use disorder (AUD) and some healthy volunteers. It may help researchers understand whether the drug is safe, and how it might affect alcohol use in AUD.
New Haven, ConnecticutAges 18–60 - NCT07815691RecruitingPhase 2
Cannabis and the brain reward system study
This study looks at how cannabis affects your brain's reward system using MRI scans. It aims to understand why some people develop cannabis use disorder, which may lead to better treatments.
Charleston, South CarolinaAges 21–45 - NCT06446479RecruitingPhase 2
THC's effect on alcohol use and brain reward
This study tests whether THC (the active ingredient in cannabis) can change how much alcohol you drink and how your brain responds to rewards. You will have MRI scans and take THC or a placebo, then drink alcohol in a controlled setting.
Aurora, ColoradoAges 21–40 - NCT06784908Recruiting
Stress and pain study for people living with HIV
This study looks at how stress affects pain in people with HIV. It may help find better ways to manage pain in this group.
New Haven, ConnecticutAges 18–68 - NCT05602649RecruitingPhase 1
How cannabis edible type changes drug levels in your body
This Phase 1 study tests how different cannabis edible formulations affect how THC shows up in your blood and how your body responds. It may help researchers choose safer, more predictable edible products based on how people absorb and react to them.
Baltimore, MarylandAges 21–55 - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT04296604Recruiting
tDCS brain stimulation to improve thinking and mood
This study tests whether a non-surgical brain stimulation called tDCS can improve “executive function,” which means skills like planning, focus, and decision-making. It is designed for people with several mental health and substance-use conditions, and it may help you if those skills are affected by your diagnosis.
Boston, MassachusettsAges 18–65 - NCT04935619Recruiting
Testing cannabis abstinence effects in depression symptoms
This study looks at how stopping cannabis for a period of time may affect depression symptoms and thinking/memory. You might benefit by getting close monitoring of mood and cognition while researchers compare changes during cannabis abstinence.
Toronto, OntarioAges 18–55 - NCT06484075RecruitingPhase 1/Phase 2
Sleep medication for alcohol use disorder
This study tests whether suvorexant, a sleep aid, can help people with alcohol use disorder by looking at brain changes. It may improve sleep and reduce drinking.
Bethesda, MarylandAges 18–75 - NCT06835907Recruiting
Baclofen for anxiety and alcohol use disorder
This trial tests if baclofen can help people with both anxiety and alcohol use disorder. It is an open-label study, meaning everyone knows they are taking the medication. Researchers want to see if it supports people in staying alcohol-free.
Jette, Brussels CapitalAges 18–65 - NCT07214207RecruitingPhase 2
Testing a sleep medicine for alcohol use disorder and stress-related drinking
This trial tests whether a medicine called suvorexant, which is used for sleep, can help people with alcohol use disorder drink less, especially when stressed. You would receive the medicine or a placebo, and researchers will track your drinking and stress levels over several weeks.
Columbus, OhioAges 18–65 - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT05863910Recruiting
Real-world study of medical cannabis use in children
This study looks at how medical cannabis is used for children and teens in everyday life, by collecting information through online questionnaires. It may help doctors and families better understand which uses are common and how people experience them.
Winnipeg, ManitobaAges 3–17 - NCT07773649RecruitingEarly Phase 1
PET scan to study energy use in brain of people with cocaine use disorder
This study uses a special PET scan to look at how brain cells make energy, which may be changed by cocaine. It might help researchers find better ways to treat cocaine use disorder.
Pittsburgh, PennsylvaniaAges 18–45 - NCT07063589Recruiting
Cannabis use patterns in young adults
This study looks at how young adults (ages 18–24) use cannabis and how it relates to their health and social life. If you join, you'll answer questions through your mobile phone over time, which helps researchers understand patterns and effects.
Montreal, QuebecAges 18–24 - NCT07732062Recruiting
Emotion-focused therapy for chronic pain patients using medical cannabis
This study tests a new type of talking therapy (vEAET-H) to see if it helps people with chronic pain who are already using medical cannabis. The goal is to find out if adding this therapy can improve pain and well-being.
Tel AvivAges 18 years+ - NCT06104280Recruiting
How opioid addiction meds affect sleep and eyes
This study tests how three common medications for opioid use disorder (methadone, buprenorphine, and naltrexone) affect eye function, sleep, and daily body rhythms. It may help find ways to improve treatment for opioid addiction.
Birmingham, AlabamaAges 18–80 - NCT06457841Recruiting
Stress and Resilience in Afro-Descent Adults
This study looks at how stress and resilience affect people who use alcohol or cannabis to cope. It's for adults of Afro-descent who have used alcohol or cannabis at least a few times recently and are not in treatment for substance use.
Dallas, TexasAges 18–30
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Common questions
- Are there clinical trials for cannabis use disorder?
- Yes. Clin2 currently lists 150 recruiting cannabis use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cannabis use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cannabis use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.