Clinical trials
Chronic Back Pain clinical trials
Below are recruiting chronic back pain clinical trials, each written for real people, not researchers. We’re tracking 329 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05721027RecruitingPhase 4
Ibuprofen alone or with a steroid for new sciatica pain
This trial compares ibuprofen alone versus ibuprofen plus dexamethasone (a steroid) for short-term relief of acute nerve-related low back pain that shoots into the buttock or leg. It aims to see which approach reduces pain and improves function after an emergency visit.
The Bronx, New YorkAges 18–70 - NCT05669027Recruiting
Mobile brain training to help low back pain
This study tests whether mobile “neurofeedback” training can reduce low back pain and improve how much it affects your daily life. You would likely use sensors that measure brain and body signals to guide the training.
Durham, North CarolinaAges 18–90 - NCT05607381Recruiting
Meditation program study for opioid-treated chronic low back pain
This trial studies how meditation may change brain activity and help people with long-lasting low back pain who are already taking prescription opioids. The goal is to understand the “neural” (brain) effects of meditation to improve pain treatment.
La Jolla, CaliforniaAges 18–65 - NCT05511012Recruiting
Testing movement-control assessment in low back pain
This study checks whether a therapist’s judgment about how your back controls movement matches objective measurements (more technical testing). It may help improve how low back pain rehabilitation is assessed and planned.
Brest, FinistèreAges 18–99 - NCT05480982Recruiting
Cognitive functional therapy versus Pilates for low back pain
This study compares two exercise-based approaches—cognitive functional therapy and Pilates—to help reduce chronic low back pain in older adults. It may help by improving how you move and manage pain, not just stretching muscles.
Rio de Janeiro, Rio de JaneiroAges 65 years+ - NCT05345015Recruiting
Radio waves for muscle or low back pain and function
This trial tests whether a high-frequency radio-wave treatment can reduce pain and improve movement in adults with a muscle strain (hamstring) or acute or chronic low back pain. It may help you feel less pain and function better, depending on your specific injury and medical details.
KavalaAges 18–65 - NCT05265000Recruiting
Skin electrical stimulation for chronic low back pain
This study tests whether a gentle electrical treatment placed on the skin near the spine can reduce chronic low back pain. If you qualify, you’ll try the stimulation and complete several assessments over a day, so the team can measure any pain and function changes.
San Francisco, CaliforniaAges 21–85 - NCT05285683RecruitingPhase 2
Study brain dopamine in people with chronic pain
This Phase 2 study looks at how a brain chemical called dopamine is involved in long-lasting pain. You may be able to join if you have chronic pain for over a year and your pain score is high enough, and if MRI and health checks are safe for you.
Rochester, New YorkAges 18 years+ - NCT05231265Recruiting
Lumbar surgery effect on walking complexity in chronic low back pain
This study looks at how lumbar spine surgery (fusion or artificial disc “prosthesis” on one or two levels) affects how complex your walking looks and feels. It may help doctors better understand what to expect from surgery and how it changes movement in people with long-term low back pain.
NîmesAges 18 years+ - NCT05052541RecruitingPhase 3
Oral cannabis for long-term spine pain
This trial studies whether taking cannabis by mouth can safely reduce chronic spine pain and improve daily comfort. You may be eligible if you have long-lasting spine pain and can follow study rules about stopping or limiting other cannabis and certain other treatments.
Aurora, ColoradoAges 21–84 - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT04270617Recruiting
Yoga practice for long-term back pain
This study looks at whether regular yoga helps people with chronic (long-lasting) back pain. If you can safely take part in yoga sessions and your pain has lasted at least 3 months, you may be able to enroll.
New York, New YorkAges 18 years+ - NCT04164225Recruiting
Testing how qigong affects brain activity in chronic low back pain
This study looks at how doing qigong may change brain activity and physical symptoms in adults with long-lasting low back pain. It’s mainly to see whether the brain and symptom measures can be identified and tracked after qigong practice.
Minneapolis, MinnesotaAges 18–70 - NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Phoenix, ArizonaAges 18 years+ - NCT03836248Recruiting
Osteopathic care added to standard treatment for chronic low back pain
This study tests whether adding osteopathic treatment to usual medical care can improve chronic low back pain. It focuses on people whose back pain has no clear structural cause and has lasted more than 3 months.
ToulouseAges 18–64 - NCT03270631Enrolling by invitation
Exercises and soft-tissue work for chronic low back pain
This study tests whether a combination of guided movement exercises and “fascial manipulation” (hands-on work on soft tissue) can help people with long-lasting low back pain. It may be an option if your back pain has not improved with non-surgery treatments or if you have post-surgery back pain.
OuluAges Any age - NCT02991625Enrolling by invitation
Brain scan study to find markers for chronic back pain
This study uses brain imaging (MRI scans) to look for “biomarkers” (measurable signs) that may relate to chronic low back pain. It compares people with long-lasting back pain to healthy volunteers to understand what brain patterns are linked to pain.
Halifax, Nova ScotiaAges 18–75 - NCT07298109Recruiting
Diaphragm Release for Chronic Low Back Pain
This study tests if releasing tension in the diaphragm muscle can help reduce chronic low back pain. It may be a treatment option for people whose back pain has lasted at least 12 weeks and has no clear cause.
KarabükAges 18–65 - NCT07277517Recruiting
Pain education plus physical therapy for new back pain
This study tests whether adding Pain Neuroscience Education (learning how your brain and nerves process pain) to standard physical therapy can help people with new low back pain feel better and move more easily. It's for adults whose pain started within the past 6 weeks and who do not have a serious spine condition.
TehranAges 18 years+ - NCT07026058Recruiting
Sound wave therapy for mechanical low back pain
This study tests whether adding sound wave therapy to standard physical therapy helps adults with long-lasting low back pain. It is for people aged 18 to 45 whose pain stays above the knee.
Lahore, Punjab ProvinceAges 18–45 - NCT07026097Recruiting
Online vs. supervised Pilates for low back pain
This study compares doing Pilates exercises online with doing them in-person under supervision. It's for people with ongoing low back pain to see which method is more effective for reducing pain and improving function.
Lahore, Punjab ProvinceAges 18–45 - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65 - NCT06590116Recruiting
Spinal manipulation for chronic low back pain
This study looks at how people feel about spinal manipulation therapy for long-term low back pain. It's for adults who have had pain in their lower back for more than three months and want to share their views on this type of treatment.
Gainesville, FloridaAges 18–70 - NCT06446596Recruiting
Phone-based exercise coach vs. standard home exercises for low back pain
This study compares doing exercises at home with a video coach on your phone versus doing standard exercises you get from a doctor. The goal is to see if the video program helps people with low back pain more than regular home exercises.
Valencia, Select OneAges 18–65
Hear when a new Chronic Back Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for chronic back pain?
- Yes. Clin2 currently lists 329 recruiting chronic back pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic back pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic back pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.