Clinical trials · California
Chronic Disease clinical trials in California
We’re tracking 95 recruiting chronic disease studies with a site in California — including Phase 1, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT06724172Recruiting
Comparing health programs for pregnant mothers from diverse backgrounds
This study tests two different health programs for pregnant women to see which one helps mothers and babies more. You may join if you are early in your pregnancy, identify as Black, Hispanic, or have Medicaid, and speak English or Spanish.
Palo Alto, CaliforniaAges 18 years+ - NCT05055297Recruiting
Drug-coated balloon for severe leg artery blockage in lower legs
This trial studies a “drug-coated balloon” procedure to improve blood flow in people with severe, long-lasting poor circulation in the lower leg arteries. It may help reduce repeat blockage after treatment for selected artery lesions below the knee.
St. Helena, CaliforniaAges 18 years+ - NCT07153939Recruiting
Study of a new device to create dialysis access
This trial tests a new device called the Velocity pAVF System that creates a connection between a vein and artery in your arm for hemodialysis. If you need dialysis now or within the next 6 months, this could be a new option for you.
Concord, CaliforniaAges 18–80 - NCT06933472RecruitingPhase 3
Study of a new phosphate binder for dialysis patients
This trial tests a new drug called AP301 to lower high phosphate levels in people on dialysis. It's designed to help control phosphate, which can be hard to manage with diet and current medications.
Granada Hills, CaliforniaAges 12 years+ - NCT07694544RecruitingPhase 1
Oral EC5026 study in people with kidney disease
This trial tests a medication called EC5026 in people with and without chronic kidney disease (CKD) to see how the body handles it. It helps understand if dose adjustments are needed for people with impaired kidney function.
Sacramento, CaliforniaAges 55 years+ - NCT07662135RecruitingPhase 3
A study of elecoglipron for type 2 diabetes with kidney problems
This trial tests a new medicine called elecoglipron to see if it helps control blood sugar in people with type 2 diabetes who also have reduced kidney function. You would continue taking your current SGLT2i medication (like dapagliflozin).
Sacramento, CaliforniaAges 18 years+ - NCT06823115Enrolling by invitation
Worldwide study of kidney injury in newborns
This study looks at how common acute kidney injury is in newborns in the intensive care unit. It helps doctors understand which babies are at risk and how to prevent kidney problems.
Palo Alto, CaliforniaAges birth–2 weeks - NCT06243068Enrolling by invitation
Supporting decisions about kidney care without dialysis
This study helps people with advanced chronic kidney disease explore their care options, including the choice to manage without dialysis. It provides support and information to help you and your family make a decision that fits your values.
San Francisco, CaliforniaAges 65 years+ - NCT05519475RecruitingPhase 2
Gene-silencing medicine trial for adults with MASH and liver scarring
This Phase 2 study tests a gene-silencing treatment to improve chronic liver disease called MASH, especially in people with certain genetic risk. You may be eligible if you have MASH with moderate-to-advanced scarring and specific test results, and if other liver causes and recent substance/alcohol issues don’t apply.
Canoga Park, CaliforniaAges 18–75 - NCT05465044Recruiting
Twice-weekly dialysis for veterans starting kidney treatment
This study compares starting hemodialysis two times per week versus three times per week for veterans in their first year of dialysis. It aims to see if a less frequent schedule can be just as safe and effective for those who still make urine.
Long Beach, CaliforniaAges 18 years+ - NCT05173714RecruitingPhase 2
Sit Less and Move More program for people with CKD
This Phase 2 study tests a program to help people with chronic kidney disease (CKD) sit less and move more, plus a medication (semaglutide) for those who qualify. It may help improve health and day-to-day activity while monitoring safety closely.
Stanford, CaliforniaAges 20 years+ - NCT05161078Enrolling by invitation
Studies CARPEDIEM care for newborns and babies in participating hospitals
This trial looks at how to improve outcomes for newborns and infants who receive CARPEDIEM as part of routine hospital care. It aims to see whether an interdisciplinary team approach can make treatment safer and more effective.
Palo Alto, CaliforniaAges Any age - NCT05106387Recruiting
Study follow-up for people who had a kidney transplant
This study follows adults who previously received vonsetamig in an earlier study and then got a kidney transplant while enrolled. It mainly looks at what happens after the transplant and helps doctors understand outcomes over time.
San Francisco, CaliforniaAges 18–70 - NCT04984226RecruitingPhase 2
Sodium bicarbonate for kidney disease energy and acidity
This trial studies whether taking sodium bicarbonate changes “energy” in cells and improves metabolic acidosis (an acid build-up) in people with moderate-to-severe chronic kidney disease. You may be able to join if your kidney function and blood bicarbonate levels fit their targets and you meet safety rules.
Sacramento, CaliforniaAges 21–85 - NCT06860828Enrolling by invitation
Football players and brain health study: DIAGNOSE CTE
This study looks at brain changes in former college and professional football players, people with memory problems, and healthy controls. It aims to learn more about chronic traumatic encephalopathy (CTE) and Alzheimer's disease.
San Francisco, CaliforniaAges 50 years+ - NCT05978141Recruiting
T-cell lymphoma registry study
This study creates a registry for people with certain T-cell or NK-cell lymphomas. It collects health information and tumor samples to learn more about these diseases and improve future treatments.
Duarte, CaliforniaAges Any age - NCT07684820RecruitingPhase 2
A study of ExPD-101 for COPD with chronic bronchitis and frequent flare-ups
This study tests an experimental drug (ExPD-101) given daily as a pill for 52 weeks for people with COPD who have chronic bronchitis and frequent flare-ups. It compares the drug to a placebo (inactive pill) to see if it reduces flare-ups and improves symptoms.
Northridge, CaliforniaAges 40–85 - NCT07646587RecruitingPhase 2
Safety Study of WIN378 for Moderate-Severe COPD
This study tests a new drug called WIN378 in people with moderate-to-severe COPD (chronic lung disease). It will check if the drug is safe and how the body processes it, which may help improve breathing and reduce flare-ups.
Los Angeles, CaliforniaAges 40–80 - NCT07059091RecruitingPhase 2
Allergy medicine for COPD with indoor allergies
This study tests if omalizumab, an allergy medicine, can help people with COPD who are allergic to common indoor allergens and have had recent flare-ups. It aims to see if reducing allergic reactions can improve COPD control.
San Francisco, CaliforniaAges 40 years+ - NCT06883305RecruitingPhase 3
Testing tezepelumab for moderate to severe COPD
This trial tests tezepelumab, an injected medication, for people with moderate to very severe COPD who still have flare-ups despite using standard inhalers. It may help reduce flare-ups and improve breathing for those with higher eosinophil levels.
Newport Beach, CaliforniaAges 40–80 - NCT06878261RecruitingPhase 3
Tezepelumab for moderate to very severe COPD
This study tests a new medication called tezepelumab (given as a shot) to see if it can reduce COPD flare-ups in people with moderate to very severe COPD who have had recent flare-ups despite using inhalers. It may be an option for those with higher levels of eosinophils (a type of white blood cell) in their blood.
Inglewood, CaliforniaAges 40–80 - NCT06716411Recruiting
Acupuncture for Gulf War Illness relief
This study tests whether acupuncture can help relieve Gulf War Illness symptoms like fatigue, mood or thinking problems, and muscle or joint pain. You may be able to join if you were deployed to the Gulf region and have had these symptoms for more than 6 months.
Los Angeles, CaliforniaAges 18 years+ - NCT06376994RecruitingPhase 3
Clean air study for COPD
This study tests if using air cleaners at home improves lung health in people with COPD. If you qualify, you may get an air cleaner for your home and be followed for 12 months.
Los Angeles, CaliforniaAges 40 years+ - NCT05572632Recruiting
COPD wellness rehab program for safety-net patients
This trial studies a COPD (chronic lung disease) wellness and rehabilitation program for people who get care through the safety-net health system. It may help improve day-to-day outcomes by supporting safer exercise and better COPD management.
San Francisco, CaliforniaAges 40–90
Chronic Disease trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting chronic disease studies listed above.
- Research Site · 3 studies
- Stanford University · 2 studies
- Apex Research
- Ark Clinical Research
- Cadena Care Institute, LLC
- California Liver Research Institute
- California Medical Research Associates Inc.
- Cedars-Sinai Medical Center
What taking part in a chronic disease study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Common questions
- Are there chronic disease clinical trials in California?
- Yes. We're currently tracking 95 recruiting chronic disease studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a chronic disease study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a chronic disease trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New chronic disease studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.