Clinical trials
Chronic Disease clinical trials
Below are recruiting chronic disease clinical trials, each written for real people, not researchers. We’re tracking 1,257 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04814082Recruiting
Compare two knee implant types for walking and function
This study compares two designs of knee replacement implants to see how they affect walking, function, and outcomes after surgery. You may be randomly assigned to one of the implant types used for your specific, approved knee replacement.
Baltimore, MarylandAges 18–75 - NCT04848636Recruiting
Sodium MRI scan to study heart salt changes in kidney disease
This trial uses a special MRI scan (called sodium MRI) to measure salt (sodium) in the heart. It compares people with chronic kidney disease (including those on hemodialysis) to healthy volunteers to understand how kidney disease may affect the heart.
London, OntarioAges 18 years+ - NCT04984226RecruitingPhase 2
Sodium bicarbonate for kidney disease energy and acidity
This trial studies whether taking sodium bicarbonate changes “energy” in cells and improves metabolic acidosis (an acid build-up) in people with moderate-to-severe chronic kidney disease. You may be able to join if your kidney function and blood bicarbonate levels fit their targets and you meet safety rules.
Sacramento, CaliforniaAges 21–85 - NCT05014178Recruiting
Kidney salt imaging scan with MRI
This study uses an MRI scan to look at how your kidneys handle salt (sodium). It may help researchers better understand kidney function in healthy people and in people with chronic kidney disease.
London, OntarioAges 18 years+ - NCT05018845RecruitingPhase 1
Testing a donated stem cell treatment for chronic kidney disease
This early study (Phase 1) tests whether an intravenously given, donated stem cell product is safe for people with chronic kidney disease. It mainly looks at side effects and whether the treatment can be given without harming you.
St John'sAges Any age - NCT05056701Recruiting
Checking early care for kidney disease after pre-eclampsia
This study looks at how to predict and diagnose chronic kidney disease (long-term kidney damage) in people who had pre-eclampsia during pregnancy, including related serious conditions. It may help identify kidney problems earlier so care can start sooner.
AngersAges 18 years+ - NCT05090865Recruiting
Increase dietary potassium before dialysis
This study tests whether eating a higher-potassium diet is safe and helpful for people with early-to-moderate kidney failure who are not yet on dialysis. You may be asked to follow a specific diet plan and have blood tests to monitor potassium and other health markers.
Winnipeg, ManitobaAges 18 years+ - NCT05095714Recruiting
Fast MRI for close monitoring of high-risk liver cancer
This trial studies a faster MRI scan to help track early liver cancer in people who have cirrhosis and are considered high risk. It may improve how often and how well doctors can look for changes without using longer imaging sessions.
BondyAges 18 years+ - NCT05149196Recruiting
Goal-directed fluid and blood pressure plan after kidney surgery
This trial tests a carefully tailored plan for managing blood pressure and fluid during and after kidney removal surgery, to help reduce kidney injury after surgery. It may be especially helpful if you’re having one kidney removed for cancer and your baseline heart/kidney risk is not too high.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05173714RecruitingPhase 2
Sit Less and Move More program for people with CKD
This Phase 2 study tests a program to help people with chronic kidney disease (CKD) sit less and move more, plus a medication (semaglutide) for those who qualify. It may help improve health and day-to-day activity while monitoring safety closely.
Stanford, CaliforniaAges 20 years+ - NCT05290363Recruiting
Studying a blood signal in active spondyloarthritis
This study looks at how a body signal called IL-23 may drive inflammation in spondyloarthritis (including joints) using samples from your care. It may help researchers identify which body cells and targets are involved, and how treatments could work better for active disease.
CréteilAges 18 years+ - NCT05321368Recruiting
Program to help control blood pressure and support health equity
This study tests a program that combines clinic care, community support, and phone-based monitoring to help people better manage blood pressure and related health problems. It aims to reduce health differences between groups that have been affected more by preventable disease.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05356325Recruiting
Testing FGF23 in anemia with and without kidney disease
This study looks at a blood hormone called FGF23 and whether it is linked to heart (cardiovascular) problems in people with anemia. It also compares people with anemia who do and do not have chronic kidney disease, which may help researchers understand risk and targets.
CórdobaAges 18–85 - NCT05359263RecruitingPhase 2
Dapagliflozin for kidney disease to improve heart structure
This Phase 2 study tests whether dapagliflozin can improve heart structure and function in people with chronic kidney disease (CKD). Dapagliflozin is a kidney-heart medicine that may affect how the heart changes over time, measured by heart scans.
CopenhagenAges 18 years+ - NCT05497518Recruiting
KidneyCARE study for adults with chronic kidney disease
This study is for adults with chronic kidney disease (CKD), including people on dialysis or with a kidney transplant. It aims to better support kidney care by allowing more community access to research.
Danville, PennsylvaniaAges 18–120 - NCT05519475RecruitingPhase 2
Gene-silencing medicine trial for adults with MASH and liver scarring
This Phase 2 study tests a gene-silencing treatment to improve chronic liver disease called MASH, especially in people with certain genetic risk. You may be eligible if you have MASH with moderate-to-advanced scarring and specific test results, and if other liver causes and recent substance/alcohol issues don’t apply.
Chandler, ArizonaAges 18–75 - NCT05546099RecruitingPhase 3
Patient-guided blood pressure control in chronic kidney disease
This Phase 3 study tests whether a patient-driven plan for managing blood pressure can better control hypertension in people with chronic kidney disease (CKD). The goal is to see if this approach is safe and helps prevent health problems related to high blood pressure.
Iowa City, IowaAges 18 years+ - NCT05570929Recruiting
Study of kidney changes before and around donation
This study follows people who are planning kidney donation or a kidney transplant to better understand how kidney function changes over time. It may help researchers predict risk and improve care by studying health markers in detail.
BerlinAges 18–75 - NCT05655325Recruiting
Exercise program to improve thinking in older adults with mild memory trouble
This study tests whether a supervised exercise plan can improve executive thinking (like planning and task control) in older adults with mild cognitive impairment. Researchers also look for brain changes using an MRI.
New York, New YorkAges 55 years+ - NCT05753020Recruiting
Kidney care planning tool for older adults with advanced kidney disease
This pilot study tests a “JumpStart” tool to help people with advanced kidney disease talk with their clinician about treatment choices in a way that matches their values. It may help you have clearer conversations about next steps before dialysis becomes necessary.
Seattle, WashingtonAges 75 years+ - NCT05858437Recruiting
Testing propionic acid to improve immune function in children with kidney failure
This study tests whether propionic acid can help the immune system work differently in children with advanced chronic kidney disease who receive regular dialysis. It may help regulate immune cells, aiming for better immune function while keeping you medically stable.
BerlinAges 12–20 - NCT05880914Recruiting
Personalized treatment study for bone disease in kidney failure
This trial looks at a personalized approach to diagnosing and treating bone problems caused by long-term kidney disease. It may help by matching treatment plans to the type of bone turnover found in your tests or biopsy.
St Louis, MissouriAges 18 years+ - NCT05970341Recruiting
Healthy food program for kidney disease and better kidney health
This trial tests whether a structured “eat well” food program—focused on kidney-friendly nutrition—can help people with early to mid-stage chronic kidney disease. It may help by supporting healthier day-to-day eating over at least 6 months.
Houston, TexasAges 18 years+ - NCT05981183Recruiting
Vagus nerve stimulation for chronic kidney disease
This study tests a device that gently stimulates a nerve in your ear to see if it can help people with chronic kidney disease (CKD). The device is non-invasive and may improve how your body handles kidney-related issues.
New York, New YorkAges 18–80
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Common questions
- Are there clinical trials for chronic disease?
- Yes. Clin2 currently lists 1,257 recruiting chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.