Clinical trials
Chronic Disease clinical trials
Below are recruiting chronic disease clinical trials, each written for real people, not researchers. We’re tracking 1,255 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07128420Enrolling by invitationPhase 1
Microneedling for chronic Peyronie's disease: a pilot study
This pilot study tests whether microneedling (tiny needles used on the skin) can safely and effectively reduce the curve caused by Peyronie's disease. If you have had a stable curve for at least 6 months and have not tried other treatments recently, you may be able to join.
Ottawa, OntarioAges 18 years+ - NCT07325253RecruitingPhase 2
PET scan study for chronic graft versus host disease
This trial uses a special PET scan to see if we can better understand chronic graft versus host disease (cGVHD), a complication after a stem cell transplant. The study is for people with joint stiffness caused by cGVHD, and it may help doctors find new ways to manage symptoms.
Houston, TexasAges 18 years+ - NCT05012033Recruiting
Study how high-dose steroids move through the body
This study measures blood levels of high-dose steroid medicines (prednisolone or related steroids) to understand how the body processes them in different real-life situations. It may help improve how steroids are dosed and monitored for people needing short-term or longer-term anti-inflammatory treatment.
LondonAges 18–75 - NCT04613921Recruiting
Liver transplant study for severe worsening liver failure
This study looks at when liver transplant is offered and what outcomes happen in people with cirrhosis who have severe “acute-on-chronic” worsening. It may help doctors decide which patients benefit most from transplant and improve care after listing or not listing.
Los Angeles, CaliforniaAges 18–80 - NCT07420907Recruiting
Tracking heart health over time
This study uses a wearable patch to monitor heart-related signs in people with heart conditions. It aims to learn more about how these conditions progress, which could help improve future care.
Chicago, IllinoisAges 18 years+ - NCT06909682Recruiting
AI monitoring with wearables for chronic heart failure
This trial tests an AI system that uses wearable devices and mini-invasive tools to monitor people with chronic heart failure. The goal is to detect changes early and help manage the condition at home.
SalernoAges 19 years+ - NCT07217522Recruiting
Genetics of pulmonary hypertension study
This study looks at the genes that may be linked to pulmonary hypertension. By providing a saliva sample and filling out a health survey from home, you can help researchers learn more about this condition.
Piscataway, New JerseyAges 18 years+ - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT01804686RecruitingPhase 3
Long-term ibrutinib follow-up with or without nivolumab
This study looks at how safe and effective ibrutinib is over the long term, either alone or together with nivolumab. You may join if you are already in an earlier ibrutinib study and your care team feels staying on ibrutinib is worth the risk.
Duarte, CaliforniaAges 18 years+ - NCT06186804Enrolling by invitationPhase 2
Study of ABSK021 for chronic graft-versus-host disease
This trial tests an experimental drug (ABSK021) for people with chronic graft-versus-host disease (cGvHD) after a stem cell transplant. It may help if other treatments haven't worked well enough.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06372990Recruiting
Quick T-cell test for hepatitis B and D
This study is testing a new blood test that quickly checks your T-cells (part of your immune system). It is for people with chronic hepatitis B or both hepatitis B and D.
Milan, MIAges 18 years+ - NCT07025538RecruitingPhase 1
Preventing chronic graft-versus-host disease with ruxolitinib
This trial tests whether the drug ruxolitinib, given based on a blood test that predicts risk, can prevent chronic graft-versus-host disease (cGVHD) after a stem cell transplant. It may help people who have a higher risk of developing this complication.
Duarte, CaliforniaAges 18 years+ - NCT05561595Recruiting
Reducing health-related stigma through group support
This trial tests a virtual group program to help people cope with health-related stigma from conditions like obesity, cancer, HIV, diabetes, skin disease, or chronic pain. It aims to reduce internalized stigma and improve well-being.
Gainesville, FloridaAges 18 years+ - NCT07711457Recruiting
Extended reality to guide brain bypass surgery
This trial tests whether extended reality (XR) technology can help surgeons more precisely plan and perform bypass surgery for people with moyamoya disease or blocked carotid arteries. It may make the procedure safer and more effective.
TaipeiAges 18–85 - NCT03573089Recruiting
Testing higher vs standard phosphate targets in dialysis patients
This trial compares two treatment goals for blood phosphate levels in people with end-stage kidney disease who are on dialysis. It may help determine which target is safer and works better in real-world care.
Camperdown, New South WalesAges 18 years+ - NCT06233110RecruitingPhase 1
Ruxolitinib and fostamatinib for steroid-resistant chronic GVHD
This study tests two drugs, ruxolitinib and fostamatinib, together for people with chronic graft-versus-host disease (GVHD) that hasn't responded well to steroids. The goal is to see if this combination can better control GVHD.
Durham, North CarolinaAges 18–80 - NCT06374537Recruiting
Exercise program for weak kidney patients
This study tests whether a targeted exercise program can help people who are very weak due to kidney disease. If you are on dialysis, have advanced kidney disease, or have had a kidney transplant, this program may improve your strength and daily function.
Chicago, IllinoisAges 18 years+ - NCT06476015Recruiting
Exercise for chronic disease patients
This study looks at whether a physical exercise program can help people with long-term health conditions like COPD or diabetes. If you are 60 to 90 years old and already part of the 'Ser más' program, you may be able to join.
Medellín, AntioquiaAges 60–90 - NCT06512493Recruiting
South East Netherlands Heart Registry
This is a heart registry that collects information from all patients to get a complete picture of heart care in the region. By including everyone, it aims to improve future treatments without bias.
Heerlen, LimburgAges Any age - NCT06515106Recruiting
Living with LGI1 encephalitis: a study on long-term symptoms
This study looks at symptoms, biomarkers, and mechanisms of the chronic phase of LGI1 antibody-mediated encephalitis. It aims to understand what happens after the acute stage and how to better manage long-term effects.
Barcelona, CataloniaAges Any age - NCT07012304RecruitingPhase 1/Phase 2
Testing gecacitinib for chronic graft-versus-host disease after 2 or more treatments
This trial tests a new drug, gecacitinib, for patients with moderate to severe chronic graft-versus-host disease (cGVHD) that has not improved after 2 to 5 prior treatments. It aims to see if the drug is safe and effective.
BeijingAges 18 years+ - NCT07033260Recruiting
Carotid ultrasound to predict low blood pressure during dialysis
This study looks at whether an ultrasound of the carotid artery (the main artery in your neck) can help predict drops in blood pressure during dialysis. It may help doctors find people at risk for low blood pressure during treatment.
Wuhu, Outside of the USAges 18–80 - NCT07529626Recruiting
Stress and Pancreatic Cancer Disease Outcomes Study
This research study examines how chronic psychological stress (long-term worry, anxiety, or emotional burden) affects the course of pancreatic cancer and related pancreatic diseases. Understanding this connection may help doctors provide better support and treatment plans for patients.
Changsha, HunanAges 18 years+ - NCT07604610Recruiting
Heart Fat and Metabolic Health in Older Adults
This study looks at fat tissue around the heart and how it relates to metabolic health (blood sugar, cholesterol, weight) in people aged 50–70. Researchers will use ultrasound imaging to measure this fat and understand its connection to heart disease risk.
MoscowAges 50–70
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Common questions
- Are there clinical trials for chronic disease?
- Yes. Clin2 currently lists 1,255 recruiting chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.