Clinical trials
Chronic Heart Failure With Reduced Ejection Fraction clinical trials
Below are recruiting chronic heart failure with reduced ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 92 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07835828Recruiting
Optimised heart and kidney protection for chronic kidney disease and heart disease
This study tests a new approach to protect the heart and kidneys in people with both chronic kidney disease and heart or blood vessel problems. By optimising treatment, researchers hope to reduce the risk of further kidney or heart damage.
SvendborgAges 18 years+ - NCT05553886RecruitingPhase 3
Tablets for chronic heart failure with low pumping strength
This Phase 3 study tests whether S086 tablets can improve treatment for people with chronic heart failure where the heart pumps weakly. You may be eligible if your heart failure symptoms are moderate to severe and your condition is stable on current medicines, but not if you’ve recently had certain heart events or can’t take related blood-pressure/heart drugs.
Shenzhen, GuangdongAges 18 years+ - NCT04343443Recruiting
Test whether a lung ultrasound helps discharge planning after heart failure
This study looks at people hospitalized for worsening heart failure with weaker pumping (reduced ejection fraction). It tests whether a lung ultrasound evaluation near discharge can improve how doctors decide it is safe to send you home.
Vandœuvre-lès-NancyAges 18 years+ - NCT05089162Recruiting
Testing a heart ultrasound approach in chronic heart failure
This study looks at people with chronic heart failure with weaker pumping function and checks how well a lung/heart ultrasound can assess congestion (fluid buildup). If you qualify, you may help test a better way to evaluate your condition during a planned hospital visit.
Vandœuvre-lès-NancyAges 18 years+ - NCT06278844Recruiting
Pacing method to improve exercise in heart failure
This study tests a new way to pace the heart in people with heart failure who need a pacemaker. It aims to see if this pacing method helps them exercise more easily.
Edegem, AntwerpAges 18 years+ - NCT04703842RecruitingPhase 1/Phase 2
Study drug effect on heart muscle calcium in advanced heart failure
This trial tests a treatment intended to improve how heart muscle cells handle calcium, which may help heart failure symptoms and heart function. It is mainly for people with advanced heart failure and a low pumping strength of the heart.
San Diego, CaliforniaAges 18–80 - NCT06286423RecruitingPhase 4
Colchicine for acute heart failure with low pumping strength
This trial tests if the anti-inflammatory drug colchicine can help people hospitalized with acute heart failure and a weak heart pump. It may benefit those with elevated inflammation markers.
Charlottesville, VirginiaAges 18 years+ - NCT07820410RecruitingPhase 2/Phase 3
Atrial shunt for heart failure with reduced pumping function
This study tests a small device that creates a tiny opening inside the heart to help lower pressure and improve symptoms in people with heart failure. The procedure is minimally invasive and aims to reduce hospitalizations and improve quality of life.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07817589Recruiting
Adding yoga to exercise rehab for heart failure
This study tests whether adding yoga to a hospital-based cardiac rehabilitation program can improve the health and well-being of people with heart failure. It might help you feel better and manage your condition more effectively.
Dharwad, KarnatakaAges 18 years+ - NCT06331208Recruiting
Mechanisms of Lung Blood Vessel Problems in Heart Failure
This study looks at how heart failure affects blood vessels in the lungs. If you have heart failure with reduced pumping ability and need a heart catheterization, you may be able to join.
PragueAges 18 years+ - NCT07761117RecruitingPhase 3
Heart failure treatment study for people with preserved pumping function
This study tests an investigational medication called elecoglipron to see if it can improve heart and blood vessel outcomes in people with heart failure with preserved or mildly reduced ejection fraction. If you join, you will receive either the study drug or a placebo, and your heart health will be monitored over time.
Fairhope, AlabamaAges 18 years+ - NCT07750873RecruitingPhase 2
Study of an investigational medicine for heart failure with reduced pumping function
This trial tests an investigational medicine called CRD-4730 (taken as a pill) to see if it can improve heart function and symptoms in people with heart failure and a reduced pumping ability. It may help you feel better and slow the progression of your condition.
Pasadena, CaliforniaAges 18–85 - NCT07701876Recruiting
Heart failure recovery markers study
This study looks for markers in the blood that can predict whether the heart's pumping function improves in people with chronic heart failure. It may help doctors understand which treatments work best for each person.
Shanghai, Shanghai MunicipalityAges 18–90 - NCT07695090RecruitingPhase 2
Lumacaftor for improved brain blood flow in heart failure
This trial tests if lumacaftor, a medication used in cystic fibrosis, can improve blood flow to the brain in people with stable heart failure. It might help if you have heart failure with reduced pumping function and low brain blood flow.
Toronto, OntarioAges 18 years+ - NCT07688863Enrolling by invitation
Comparing breathing muscle training methods for heart failure
This trial compares two different types of breathing muscle training to see which works better for people with heart failure and weak breathing muscles. You may join if you have heart failure with reduced pumping ability and are stable overall.
Viña del Mar, ValparaisoAges 18 years+ - NCT07650474Recruiting
Mobile app for heart failure management and quality of life
This study tests whether using a mobile phone app to monitor and manage chronic heart failure improves how you feel and function day-to-day. Researchers will check in with you regularly through your phone to track your symptoms and health.
Addis AbabaAges 18–65 - NCT07631156RecruitingPhase 4
Safely Reducing Heart Failure Medications After Recovery
This study tests whether patients whose heart function has fully recovered after surgery or a heart procedure can safely reduce or stop their heart failure medications. Researchers will carefully monitor whether gradually lowering these medicines is safe and maintains heart health.
Daegu, DaeguAges 19 years+ - NCT07595809Recruiting
Diet and exercise for heart failure with weak heart pumping
This study tests whether combining a healthy eating plan (DASH diet) with supervised exercise can help people with heart failure where the heart doesn't pump strongly enough. The goal is to see if these lifestyle changes improve heart function and symptoms.
Zabrze, Silesian VoivodeshipAges 30 years+ - NCT07581587Recruiting
Breathing Exercises and Brain Function in Heart Failure
This study tests whether special breathing exercises—done alone or while doing a mental task—can improve memory and thinking skills in people with heart failure. Researchers want to see if training your breathing muscles helps your brain work better.
Istanbul, FatihAges 40 years+ - NCT06249932RecruitingPhase 4
Empagliflozin for heart failure and end-stage kidney disease
This trial tests whether empagliflozin, a medication for heart failure, can help people who also have end-stage kidney disease and are on dialysis. It aims to see if the drug improves heart function in this group.
Hsinchu, TaiwanAges 20 years+ - NCT07547540RecruitingPhase 1
Study of an investigational drug for heart failure
This study tests an experimental drug called LY3971297 to see if it can help people with chronic heart failure. It aims to find out if the drug is safe and if it improves heart function.
Detroit, MichiganAges 18–65 - NCT07518030Recruiting
Telemedicine support for heart failure medication adjustment
This study tests whether remote check-ins via phone or video can help safely increase heart failure medications to target doses. You'll use a device to share weight, blood pressure, and heart rate with your doctor, who will adjust your medicines based on how you're doing.
PiacenzaAges 18 years+ - NCT07513883RecruitingPhase 4
Reducing Heart Failure Medications When Your Heart Recovers
This study tests whether patients whose heart failure has improved can safely reduce some of their medications. If your heart function has recovered significantly and stayed stable, this trial explores whether you can gradually lower doses of heart failure drugs while staying healthy.
GenkAges 18 years+ - NCT07490054RecruitingPhase 1
Fecal transplant for chronic heart failure
This trial tests whether transferring healthy gut bacteria (fecal microbiota transplant) can help people with chronic heart failure feel better and improve their heart function.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for chronic heart failure with reduced ejection fraction?
- Yes. Clin2 currently lists 92 recruiting chronic heart failure with reduced ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic heart failure with reduced ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic heart failure with reduced ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.