Clinical trials
Heart Failure With Mildly Reduced Ejection Fraction clinical trials
Below are recruiting heart failure with mildly reduced ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 31 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05508256RecruitingPhase 4
Ablation for atrial fibrillation in heart failure with preserved function
This trial tests whether a catheter procedure that treats atrial fibrillation works better than standard care for people with heart failure with preserved ejection fraction. It aims to improve heart rhythm symptoms and overall outcomes compared with conventional treatment.
BerlinAges 18 years+ - NCT07761117RecruitingPhase 3
Heart failure treatment study for people with preserved pumping function
This study tests an investigational medication called elecoglipron to see if it can improve heart and blood vessel outcomes in people with heart failure with preserved or mildly reduced ejection fraction. If you join, you will receive either the study drug or a placebo, and your heart health will be monitored over time.
Fairhope, AlabamaAges 18 years+ - NCT07741305Recruiting
Comparing heart ultrasound imaging methods for heart failure
This study tests whether a 3D ultrasound of the heart gives better information than a standard 2D ultrasound in people with heart failure. It aims to improve how doctors measure heart function, which could help guide treatment.
Bari, BAAges 18 years+ - NCT07688863Enrolling by invitation
Comparing breathing muscle training methods for heart failure
This trial compares two different types of breathing muscle training to see which works better for people with heart failure and weak breathing muscles. You may join if you have heart failure with reduced pumping ability and are stable overall.
Viña del Mar, ValparaisoAges 18 years+ - NCT07543562RecruitingPhase 3
Selenium supplement for heart failure patients
This study tests whether taking selenium (a mineral supplement) helps heart failure patients feel better and live longer. Researchers will follow patients over time to see if selenium reduces symptoms and hospital visits.
OsloAges 18 years+ - NCT07467668Recruiting
Iron infusion for heart failure patients with low iron
This trial tests whether giving intravenous iron to adults hospitalized with heart failure and low iron levels helps improve their health. You may be eligible if you have heart failure with reduced pumping function and low iron stores.
Pleasanton, CaliforniaAges 18 years+ - NCT07460531Recruiting
Physical activity and heart health in chronic heart failure
This study looks at how physical activity affects heart outcomes in people with chronic heart failure. If you have a pedometer or activity tracker, you may be able to join.
Munich, BavariaAges 18 years+ - NCT07442448Enrolling by invitationPhase 4
Study of Finerenone for heart and kidney health in diabetes
This trial tests a medication called Finerenone to see if it can improve heart structure and function in people with both diabetic kidney disease and heart failure. If you have type 2 diabetes, kidney problems, and heart failure with preserved pumping function, this study may explore a new treatment option for you.
TaipeiAges 18 years+ - NCT06851949RecruitingPhase 2
Vsling device for ventricular repair in heart failure
This trial tests a new device called Vsling, which is placed inside the heart to help reshape the main pumping chamber (left ventricle) in people with heart failure. It may improve your heart's strength and reduce symptoms like shortness of breath.
Be’er Ya‘aqovAges 18 years+ - NCT07272902Recruiting
Atrial fibrillation treatment: Ablation vs. medication
This trial compares two ways to treat atrial fibrillation in people with heart failure where the heart's pumping strength is still normal. You'll either get a procedure called ablation to restore normal rhythm or medication to control your heart rate. The goal is to see which approach works better for people like you.
Halifax, Nova ScotiaAges 18 years+ - NCT05583773RecruitingPhase 4
Herbal medicine for heart failure with lower pumping strength
This trial tests SHengXIaN-QuYu decoction (an herbal treatment) in people with symptomatic heart failure and reduced pumping function. It looks to see whether the herbal formula is safe and helpful for heart failure symptoms and heart function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07218627RecruitingPhase 1
Study of an investigational medicine for heart failure
This study tests an experimental medicine called NNC0537-1482 for people with heart failure. It aims to see if the medicine helps improve symptoms and heart function.
LondonAges 40–75 - NCT07204834Enrolling by invitation
Physical activity program for heart failure
This study tests a home-based physical activity program for people with heart failure. The program is designed to be safe and easy to follow, using a smartphone app to guide you, and may help you feel stronger and more active.
GranadaAges 18 years+ - NCT06939985Recruiting
Heart health and metabolism registry for heart failure
This trial is a registry that will follow people with different types of chronic heart failure to better understand how heart health and metabolism are linked. It may help doctors improve care for future patients.
ShanghaiAges 18 years+ - NCT07147114RecruitingPhase 4
Combined macitentan and dapagliflozin for heart failure with lung high blood pressure
This trial tests whether adding two medications—macitentan and dapagliflozin—together is safe and effective for people with heart failure and a certain type of high blood pressure in the lungs. It might help improve your symptoms and daily function.
BusanAges 19 years+ - NCT07054489Recruiting
Genetic guided beta blocker therapy for heart failure
This trial tests whether a genetic test can help doctors choose the best beta blocker for people with heart failure who have mildly reduced pumping function. It aims to improve treatment by matching the drug to your genetic profile.
Detroit, MichiganAges 18–89 - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Birmingham, AlabamaAges 18–99 - NCT06965504Recruiting
Heart failure medications with an Impella heart pump for cardiogenic shock
This study tests whether a special heart pump (Impella 5.5) can help patients with severe heart failure (cardiogenic shock) safely start and increase their heart failure medications. The goal is to see if this approach can help the heart recover and improve outcomes.
Tampa, FloridaAges 18–80 - NCT06937320Enrolling by invitationPhase 2
Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Durham, North CarolinaAges 18 years+ - NCT06552637Recruiting
Diaphragm stimulation for heart failure
This trial tests a device that stimulates your diaphragm (the muscle that helps you breathe) while you have heart failure. It may help improve your breathing and heart function. The study is for people with moderate heart failure symptoms whose heart pumps less blood than normal.
Indianapolis, IndianaAges 18 years+ - NCT06518694RecruitingPhase 3
Can you stop beta-blockers after heart failure recovery?
This trial tests whether people whose heart function has returned to normal after heart failure can safely stop taking beta-blockers. It aims to see if staying on the medication is still needed or if stopping is just as safe.
Paris, IDFAges 18 years+ - NCT06008197RecruitingPhase 3
A study of finerenone for hospitalized heart failure patients
This trial tests a medication called finerenone to see if it helps people hospitalized for heart failure live longer and have fewer heart-related problems. It may be an option for those with a certain type of heart failure where the heart's pumping strength is mildly reduced or normal.
Birmingham, AlabamaAges 18 years+ - NCT05651919Recruiting
Blood test study to understand diabetic heart weakness
This study measures immune cells from your blood to find markers (biomarkers) that may explain or predict diabetic cardiomyopathy, a type of heart condition linked to diabetes. You may benefit mainly by being closely monitored and contributing to research that could improve future diagnosis or risk tracking.
BronAges 40–85 - NCT05138575RecruitingPhase 2
Testing SGLT2 pill and potassium nitrate for heart failure with preserved EF
This trial studies whether two medicines—an SGLT2 inhibitor and potassium nitrate—can improve symptoms and heart function in people with heart failure with preserved ejection fraction (HFpEF). It focuses on people who still have signs of “stiff” or high filling pressure in the heart despite a normal-ish ejection fraction.
Philadelphia, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for heart failure with mildly reduced ejection fraction?
- Yes. Clin2 currently lists 31 recruiting heart failure with mildly reduced ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure with mildly reduced ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure with mildly reduced ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.