Clinical trials
Chronic Kidney Disease Stage 4 clinical trials
Below are recruiting chronic kidney disease stage 4 clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06933472RecruitingPhase 3
Study of a new phosphate binder for dialysis patients
This trial tests a new drug called AP301 to lower high phosphate levels in people on dialysis. It's designed to help control phosphate, which can be hard to manage with diet and current medications.
Granada Hills, CaliforniaAges 12 years+ - NCT06858280RecruitingPhase 3
Patiromer and diet for potassium in dialysis patients
This trial tests if a medication called patiromer, combined with a low-potassium diet, can help manage potassium levels in people on chronic dialysis. The goal is to improve quality of life by allowing a more flexible diet.
Bergamo, BGAges 18 years+ - NCT06799936Recruiting
Helping older adults with kidney disease make treatment choices
This study tests a program that helps older adults with advanced chronic kidney disease talk with their doctors about treatment options, like dialysis, palliative care, or a kidney transplant. It aims to make sure patients' values and preferences are heard in these important decisions.
Hong KongAges 65 years+ - NCT06725810RecruitingPhase 4
Enarodustat for anemia in chronic kidney disease (not on dialysis)
This trial tests enarodustat, a pill for anemia, in people with chronic kidney disease who are not on dialysis. It aims to see if it can safely raise hemoglobin levels.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06741072RecruitingPhase 1
Vaccine to prevent EBV-related cancer in transplant patients
This trial tests a vaccine (OSU-2131) that may help prevent cancers caused by the Epstein-Barr virus in people waiting for an organ transplant. The vaccine is designed to train your immune system to fight the virus.
Columbus, OhioAges 18–65 - NCT06712654RecruitingPhase 2
Testing AP306 for high phosphate in dialysis patients
This trial tests a new medication called AP306 for people on hemodialysis who have high blood phosphate. It aims to see if the drug is safe, tolerable, and helps lower phosphate levels.
Huntsville, AlabamaAges 18 years+ - NCT06660277Recruiting
Dialysis with expanded solute removal study
This trial tests a special dialysis filter (Elisio HX) that removes more waste products from the blood. It aims to see if this approach improves health outcomes for people on regular in-center hemodialysis.
London, OntarioAges 45 years+ - NCT06466785RecruitingPhase 3
Study of Efepoetin Alfa for anemia in kidney dialysis patients
This study tests a new drug called Efepoetin Alfa to treat anemia in people with chronic kidney disease who are on dialysis. The goal is to see if it can safely raise red blood cell levels and reduce the need for other anemia treatments.
YerevanAges 18 years+ - NCT06463483Recruiting
Automated Insulin Delivery for People with Advanced Kidney Disease
This trial tests an automated insulin pump system for people with diabetes who also have advanced kidney disease. It may help manage blood sugar more easily.
LondonAges 18–70 - NCT06329622RecruitingPhase 3
Does Ketosteril help muscle loss in kidney disease?
This study tests whether a medicine called Ketosteril can improve muscle strength and function in people with moderate to severe chronic kidney disease (CKD) who also have sarcopenia (age-related muscle loss).
ShanghaiAges Any age - NCT06173323Recruiting
Improving decision-making for kidney disease patients and their caregivers
This study tests a program to help people with advanced chronic kidney disease (stage 4 CKD) and their caregiver work together on medical decisions. It aims to see if the program improves communication and partnership.
Birmingham, AlabamaAges 18 years+ - NCT06001827Recruiting
Study of a wrap to help new dialysis access points heal
This trial tests a special wrap placed around a new arm access point for dialysis (called an AV fistula) to see if it helps the access stay healthy and work better. It is for people who need a new AV fistula for kidney dialysis.
Bullhead City, ArizonaAges 18 years+ - NCT05870007Enrolling by invitationPhase 2
Atorvastatin and alkalizing treatment for autosomal dominant PKD
This Phase 2 study tests whether atorvastatin plus an “alkalizing” treatment (sodium bicarbonate) can slow or improve disease effects in people with autosomal dominant polycystic kidney disease (ADPKD). It specifically targets metabolic acidosis (when the body becomes “too acidic”), which may worsen kidney health.
New Taipei CityAges 18 years+ - NCT05525507RecruitingPhase 1
Test early immune-tolerance treatment for matched kidney transplant patients
This Phase 1 study tests a treatment plan given after a kidney transplant to help the immune system stay calm and reduce the risk of rejection. Participants must have a well-functioning kidney transplant from a closely matched living donor and meet health and safety requirements.
Los Angeles, CaliforniaAges 18 years+ - NCT05846581Recruiting
Dialysis graft registry for adults getting a new vascular graft
This registry follows adults with kidney failure who need a dialysis access connection in the arm using the GORE ACUSEAL graft. It helps track outcomes and safety over time while you receive standard dialysis care.
BielefeldAges 18 years+ - NCT05465044Recruiting
Twice-weekly dialysis for veterans starting kidney treatment
This study compares starting hemodialysis two times per week versus three times per week for veterans in their first year of dialysis. It aims to see if a less frequent schedule can be just as safe and effective for those who still make urine.
Long Beach, CaliforniaAges 18 years+ - NCT05457283RecruitingPhase 3
Finerenone safety study for children with kidney disease
This trial studies how safely finerenone works over 18 months in children and young adults with chronic kidney disease who also take an ACE inhibitor or ARB. It aims to better understand long-term side effects when used together with standard kidney blood-pressure medicines.
Phoenix, ArizonaAges 1–18 - NCT04708587Recruiting
Choosing the right anti-platelet duration for advanced kidney disease
This study looks at the best length of anti-platelet medicine (which helps prevent stent clots) after a new type of heart stent. It specifically focuses on people with advanced chronic kidney disease, where bleeding and clot risks can be higher.
SeoulAges 19–84 - NCT04671771Recruiting
Testing a new graft for hemodialysis access in kidney failure
This study tests whether an “AV graft” implant works safely and well for people with end-stage kidney disease who need hemodialysis. It may help your dialysis access last and work better, compared with current expectations for AV grafts.
Phoenix, ArizonaAges 18–90 - NCT04397159Recruiting
Exercise program to reduce tiredness in some kidney patients
This trial studies whether doing a combination exercise program can reduce “fatigability,” meaning feeling unusually tired or weak during activity, in Veterans with moderate-to-advanced chronic kidney disease. It also compares results with people without kidney disease and checks for safety, especially for heart and joint health.
Washington D.C., District of ColumbiaAges 50–85 - NCT04185844Recruiting
Chronic kidney health study for Native American adults
This study follows Native American adults with kidney function changes (either moderately reduced kidney filtration or early urine protein). It aims to better understand kidney disease over time and what factors predict progress, which may help improve care for people like you.
Phoenix, ArizonaAges 21–80 - NCT03573089Recruiting
Testing higher vs standard phosphate targets in dialysis patients
This trial compares two treatment goals for blood phosphate levels in people with end-stage kidney disease who are on dialysis. It may help determine which target is safer and works better in real-world care.
Camperdown, New South WalesAges 18 years+ - NCT03716401Recruiting
Imaging tests to predict kidney disease in type 2 diabetes
This study uses special kidney imaging to look for patterns that can predict how diabetic kidney disease may progress. It may help researchers find better ways to identify people at higher risk using noninvasive (and possibly biopsy-related) tests.
TurkuAges 18–80 - NCT07271186RecruitingPhase 2
Study of an experimental drug for kidney disease from type 2 diabetes
This study tests an investigational drug called ALN-ANG3 to see if it can help people with diabetic kidney disease. The drug may reduce kidney damage and slow down the loss of kidney function. If you join, you will get the study drug or a placebo (a dummy shot) and be followed by a study doctor.
Huntsville, AlabamaAges 18–80
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Common questions
- Are there clinical trials for chronic kidney disease stage 4?
- Yes. Clin2 currently lists 148 recruiting chronic kidney disease stage 4 studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic kidney disease stage 4 trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic kidney disease stage 4 trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.