Clinical trials
Chronic Low Back Pain clinical trials
Below are recruiting chronic low back pain clinical trials, each written for real people, not researchers. We’re tracking 268 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05607381Recruiting
Meditation program study for opioid-treated chronic low back pain
This trial studies how meditation may change brain activity and help people with long-lasting low back pain who are already taking prescription opioids. The goal is to understand the “neural” (brain) effects of meditation to improve pain treatment.
La Jolla, CaliforniaAges 18–65 - NCT05508360Recruiting
Testing an artificial spacer implant for one-level low back pain
This study tests whether inserting a small artificial implant into a single painful disc can reduce long-term low back pain and disability. It’s for people who tried non-surgical treatments for at least 6 months but still have significant symptoms from degenerative disc disease.
Medellín, AntioquiaAges 22 years+ - NCT05511012Recruiting
Testing movement-control assessment in low back pain
This study checks whether a therapist’s judgment about how your back controls movement matches objective measurements (more technical testing). It may help improve how low back pain rehabilitation is assessed and planned.
Brest, FinistèreAges 18–99 - NCT05480982Recruiting
Cognitive functional therapy versus Pilates for low back pain
This study compares two exercise-based approaches—cognitive functional therapy and Pilates—to help reduce chronic low back pain in older adults. It may help by improving how you move and manage pain, not just stretching muscles.
Rio de Janeiro, Rio de JaneiroAges 65 years+ - NCT05422040Recruiting
Dry needling or tecartherapy for long-term low back pain
This study compares two physical therapies—dry needling versus tecartherapy—to see which helps people with long-lasting, non-specific low back pain. You may be eligible if your pain has lasted more than 6 weeks and is not caused by nerve or serious underlying conditions.
Alcalá de Henares, MadridAges 18–65 - NCT05345015Recruiting
Radio waves for muscle or low back pain and function
This trial tests whether a high-frequency radio-wave treatment can reduce pain and improve movement in adults with a muscle strain (hamstring) or acute or chronic low back pain. It may help you feel less pain and function better, depending on your specific injury and medical details.
KavalaAges 18–65 - NCT05265000Recruiting
Skin electrical stimulation for chronic low back pain
This study tests whether a gentle electrical treatment placed on the skin near the spine can reduce chronic low back pain. If you qualify, you’ll try the stimulation and complete several assessments over a day, so the team can measure any pain and function changes.
San Francisco, CaliforniaAges 21–85 - NCT05231265Recruiting
Lumbar surgery effect on walking complexity in chronic low back pain
This study looks at how lumbar spine surgery (fusion or artificial disc “prosthesis” on one or two levels) affects how complex your walking looks and feels. It may help doctors better understand what to expect from surgery and how it changes movement in people with long-term low back pain.
NîmesAges 18 years+ - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT04824248Recruiting
Weight-loss program for chronic low back pain
This trial studies whether weight loss can improve long-lasting, non-specific low back pain. It may help people whose back pain is partly related to extra weight by testing a structured approach over time.
BrusselsAges 18–65 - NCT04730700Recruiting
Radiofrequency treatment test for facet back pain
This study compares a nerve procedure (radiofrequency “neurotomy” using an expandable electrode) to non-procedure medical care for long-lasting low back pain from facet joints. It aims to see whether the procedure helps more safely than conservative treatment.
Kansas City, KansasAges 18 years+ - NCT04164225Recruiting
Testing how qigong affects brain activity in chronic low back pain
This study looks at how doing qigong may change brain activity and physical symptoms in adults with long-lasting low back pain. It’s mainly to see whether the brain and symptom measures can be identified and tracked after qigong practice.
Minneapolis, MinnesotaAges 18–70 - NCT04226716Recruiting
Studying pelvic pain causes in multiple or first pregnancies
This study looks at why pelvic girdle pain happens during pregnancy, focusing on body sensing (proprioception), stress factors, and inflammation. You may be able to help researchers understand the causes and who is most at risk.
HasseltAges 18–40 - NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Phoenix, ArizonaAges 18 years+ - NCT03912519Enrolling by invitation
Testing two ways to numb lumbar back pain with radiofrequency
This study compares two needle-based techniques to treat long-lasting low back pain by stopping overactive pain signals from specific back joints. If you’ve already tried physical therapy and pain medicines without enough relief, this trial may test which technique works better for pain reduction.
Nashville, TennesseeAges 40 years+ - NCT03836248Recruiting
Osteopathic care added to standard treatment for chronic low back pain
This study tests whether adding osteopathic treatment to usual medical care can improve chronic low back pain. It focuses on people whose back pain has no clear structural cause and has lasted more than 3 months.
ToulouseAges 18–64 - NCT03270631Enrolling by invitation
Exercises and soft-tissue work for chronic low back pain
This study tests whether a combination of guided movement exercises and “fascial manipulation” (hands-on work on soft tissue) can help people with long-lasting low back pain. It may be an option if your back pain has not improved with non-surgery treatments or if you have post-surgery back pain.
OuluAges Any age - NCT02991625Enrolling by invitation
Brain scan study to find markers for chronic back pain
This study uses brain imaging (MRI scans) to look for “biomarkers” (measurable signs) that may relate to chronic low back pain. It compares people with long-lasting back pain to healthy volunteers to understand what brain patterns are linked to pain.
Halifax, Nova ScotiaAges 18–75 - NCT07038434Recruiting
Using artificial intelligence to measure pain in chronic pain patients
This study uses artificial intelligence to better understand and measure pain in people with chronic pain. The goal is to develop smarter ways to assess pain automatically, which could lead to better treatment.
Salerno, ItalyAges 18 years+ - NCT06983678Recruiting
Quitting smoking and pain sensitivity study
This study looks at how quitting smoking affects pain sensitivity in people who smoke, especially those with chronic low back pain. Researchers will use brain scans and daily surveys to understand these changes.
Durham, North CarolinaAges 21–65 - NCT06083597Enrolling by invitation
Developing a pelvic pain questionnaire for women
This study aims to develop a new questionnaire to better understand and measure chronic pelvic pain in women, especially when it's linked to enlarged pelvic veins. You will be asked to take part in interviews and fill out surveys to help create a tool that reflects your experience.
New York, New YorkAges 18–60 - NCT07595718Recruiting
Using health data and AI to predict major diseases
This study uses your health information and artificial intelligence to help predict the onset of major diseases. By joining, you could help improve early detection and prevention for conditions like diabetes, heart disease, and cancer.
Seoul, Seoul Special CityAges 30–65 - NCT07590050Recruiting
Catgut Embedding for Lower Back Pain and Blood Stasis
This trial tests catgut embedding (a traditional acupuncture technique using absorbable material) to treat chronic lower back pain caused by spine wear-and-tear, particularly for patients whose condition matches a traditional medicine pattern called 'blood stasis.' The goal is to see if this approach relieves pain and improves movement.
Ho Chi Minh City, Ho Chi Minh CityAges 18–65 - NCT05641948Recruiting
Tested nerve ablation plus brain scans for ongoing back pain
This trial studies a procedure called radiofrequency denervation to reduce long-lasting, mostly “pain-from-joints/structures” low back pain, and it uses brain imaging to understand what changes during treatment. It may help people who already showed they respond well to a similar diagnostic nerve block.
Aberdeen, ScotlandAges 18 years+
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Common questions
- Are there clinical trials for chronic low back pain?
- Yes. Clin2 currently lists 268 recruiting chronic low back pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic low back pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic low back pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.