Clinical trials
Cognitive Decline clinical trials
Below are recruiting cognitive decline clinical trials, each written for real people, not researchers. We’re tracking 172 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04390646RecruitingPhase 2/Phase 3
Hormone treatment to study thinking in Down syndrome
This trial studies whether a GnRH hormone treatment can improve thinking and memory in people with Down syndrome. It also checks safety and whether the treatment affects brain-related changes seen on MRI.
Lausanne, Canton of VaudAges 16–50 - NCT06246929Recruiting
Healthy aging for Black adults with chronic pain and memory concerns
This study tests a program to help Black adults aged 50+ manage chronic pain and early memory changes. It compares two approaches to see which works better for improving daily life and thinking skills.
Boston, MassachusettsAges 50 years+ - NCT05036538Recruiting
Reducing pre-surgery stress to help prevent confusion after heart surgery
This study tests whether a stress-reducing relaxation method before heart surgery can lower the risk of postoperative delirium (sudden confusion) and longer-term thinking problems. It may help you keep clearer thinking in the days and weeks after surgery.
Bad Nauheim, HesseAges 18 years+ - NCT05014399Recruiting
Study memory changes during chemotherapy for colorectal cancer
This study looks at cognitive (thinking and memory) changes in people with colorectal cancer who start certain chemotherapy drugs. It aims to understand how treatment affects the brain and may guide better monitoring or support during care.
Fort Wayne, IndianaAges 18 years+ - NCT07383311Recruiting
Natural supplements for memory and sleep
This study tests whether certain natural compounds (autophagy enhancers) can improve sleep in people with age-related memory concerns, including those with mild cognitive impairment and those with only subjective declines.
Greifswald, Mecklenburg-VorpommernAges 55–75 - NCT07610109Recruiting
Community Support Programs for Brain Health in Older Adults
This study tests whether community activities and support programs help older adults keep their thinking skills sharp and improve their quality of life. You would attend programs at a life center and complete some simple assessments.
Istanbul, BagcılarAges 60 years+ - NCT04201600Recruiting
Study how blood sugar swings affect thinking in prediabetes
This study looks at how “blood sugar variability” (how much glucose levels bounce around) may affect thinking and memory in people with prediabetes. You may be eligible if you’re older and don’t already have diabetes or conditions that can strongly affect the brain or blood vessels.
Baltimore, MarylandAges 50 years+ - NCT06836141Recruiting
Biomarkers for memory decline after brain hemorrhage
This study looks for biological signs that might predict memory problems after a brain bleed, which could help doctors provide better care.
Chicago, IllinoisAges 18–80 - NCT06034509Recruiting
Thinking and blood vessel health after head injury
This study looks at how a past traumatic brain injury (TBI) might affect your thinking skills and blood vessel health over time. You may be eligible if you had a TBI at least 3 years ago and have already completed an earlier evaluation at the National Intrepid Center of Excellence (NICoE).
Bethesda, MarylandAges 18–74 - NCT05655325Recruiting
Exercise program to improve thinking in older adults with mild memory trouble
This study tests whether a supervised exercise plan can improve executive thinking (like planning and task control) in older adults with mild cognitive impairment. Researchers also look for brain changes using an MRI.
Washington D.C., District of ColumbiaAges 55 years+ - NCT07165236Recruiting
Bladder tumor surgery and memory changes study
This study looks at how bladder tumor surgery might affect thinking and memory. It checks blood markers to see if they are linked to any mental changes after the operation.
Osijek, CroatiaAges 18–80 - NCT06551857Recruiting
How cancer treatments affect hearing and thinking
This study looks at how common cancer treatments (certain chemotherapies and radiation to the head and neck) affect hearing in noisy places, thinking skills, and quality of life related to hearing. It aims to understand and possibly reduce these side effects.
Turku, Southwest FinlandAges 18–75 - NCT06290167Recruiting
Dual-task rehab for memory concerns in older adults
This study tests a new rehab program that combines physical and mental tasks for older adults with early memory issues. It aims to help improve daily function and possibly slow decline.
Milan, MIAges 65 years+ - NCT06336174Recruiting
Thinking and Memory in Brain Artery Narrowing: A Study
This study looks at how severe narrowing of brain arteries may affect memory and thinking over time. It involves people who have had a mini-stroke or mild stroke and aims to understand the changes in cognitive function.
Hefei, AnhuiAges 18–80 - NCT07134699Recruiting
Back pain's effect on thinking in older adults
This study looks at how long-term lower back pain affects thinking skills like memory and attention in adults aged 60 to 85. Participants must speak Cantonese, be right-handed, and have normal thinking abilities. The study uses email or text for some tasks.
Hong KongAges 60–85 - NCT07087951Recruiting
Sound therapy for memory loss in older adults
This study tests whether listening to a special sound (gamma-frequency tones) can help slow down memory loss in older adults. It's for people who have mild memory problems but not dementia or other brain disorders.
Taoyuan, GuishanAges 60 years+ - NCT07775833Recruiting
Mushroom supplement to slow memory decline in at-risk adults
This trial tests whether eating mushrooms regularly can help prevent memory loss in people who are at higher risk for Alzheimer's disease but do not have dementia. If you are between 45 and 80, have some memory concerns, and currently eat mushrooms rarely, this study may be a good fit.
SingaporeAges 45–80 - NCT07315724Recruiting
Block training for brain and hand health in older adults
This trial tests whether a technology-assisted block training program can improve thinking skills, hand coordination, and grip strength in older adults living in the community. It may help keep your mind and hands active as you age.
Yilan, TaiwanAges 65 years+ - NCT05306834Recruiting
Study to slow memory decline by targeting hidden small brain vessel disease
This trial looks at how to slow cognitive decline and early dementia in people with a specific kind of “silent” blood vessel damage in the brain seen on scans. It may help identify whether targeting this hidden condition can protect thinking and memory over time.
BordeauxAges 60–88 - NCT02800395Recruiting
Study links brain changes to diet and blood markers in Alzheimer’s
This study looks at how diet-related and blood “stress” markers relate to how thinking and memory decline over time in people with Alzheimer’s. It may help researchers find useful biomarkers to better track progression and guide future care.
Pierre-BéniteAges 55 years+ - NCT06375213Recruiting
Memory and thinking study for all ages
This study looks at how well people think and remember as they age. It includes healthy volunteers, people with mild memory issues, and those with dementia—both early- and late-onset.
Pathum Wan, BangkokAges 35 years+ - NCT03946930Recruiting
Study of memory decline in Alzheimer’s disease
This trial studies people diagnosed with Alzheimer’s disease who are at a moderate stage of decline. It likely involves cognitive (memory/thinking) testing and care-partner input to help track changes over time.
Hong KongAges 65–92 - NCT07698431Recruiting
Personalized brain health service for dementia prevention
This trial tests a personalized brain health program for people aged 55-85 who have minor memory or thinking worries but are still mentally sharp. It uses technology like smartphones and computers to help you stay healthy and prevent dementia.
Barcelona, CataloniaAges 55–85 - NCT07623785Recruiting
Beef and Brain Health in Older Adults
This study looks at whether eating lean beef and dairy products daily affects brain health markers in people 65 and older. Researchers will track blood, urine, and other samples to see if beef consumption influences how your brain functions at the molecular level.
Brookings, South DakotaAges 65 years+
Hear when a new Cognitive Decline trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for cognitive decline?
- Yes. Clin2 currently lists 172 recruiting cognitive decline studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive decline trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive decline trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.