Clinical trials
Cognitive Decline clinical trials
Below are recruiting cognitive decline clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06661486Recruiting
Lifestyle program to delay cognitive decline in older adults
This trial tests whether a lifestyle program can help delay memory and thinking decline in older adults who are showing early signs of cognitive slowing but do not have dementia. You would join a group program focused on healthy habits like exercise, diet, and mental activities.
Singapore, SingaporeAges 60–75 - NCT05988385Recruiting
Treating sleep apnea to protect memory in older adults
This study tests whether treating sleep apnea can help protect memory and brain health in older adults. It involves using a CPAP machine or other treatments for sleep apnea and may include memory tests and brain scans over 2 years.
Tucson, ArizonaAges 55–85 - NCT06632145Recruiting
A health promotion program for older adults with memory changes
This study tests a group program called Cog-Fun Ageing that helps older adults with memory changes stay active and healthy. If you have mild memory issues but can still think clearly, you may be able to join this Hebrew-speaking program.
JerusalemAges 60 years+ - NCT05256745RecruitingPhase 1/Phase 2
A medicine to protect the heart during breast cancer chemotherapy
This early-phase study tests azeliragon to lower the risk of chemotherapy-related heart damage in women with early-stage breast cancer. Participants get their planned standard chemotherapy, plus the study medicine, and are monitored for safety and heart health.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05124132Enrolling by invitation
Study of resilience and brain health after an earlier parent study
This trial looks at how resilience (how well people cope with stress) and brain health change over time in older adults who already joined an earlier study. You may be eligible if you participated in that “parent study.”
St Louis, MissouriAges 65 years+ - NCT07389213Recruiting
Can brain stimulation and hearing aids slow memory loss in older adults with hearing loss?
This trial tests whether a non-invasive brain stimulation technique (rTMS) combined with hearing aids can help slow down thinking and memory decline in older adults who have age-related hearing loss.
Guangzhou, GuangdongAges 50–85 - NCT06896825Recruiting
Staying active with social support and stress relief
This study tests whether a program that combines social support and stress management can help older adults who live alone become more physically active. You'll use a smartphone to track your activity and get support from others.
Phoenix, ArizonaAges 60 years+ - NCT07160673Recruiting
Tech-based caregiver break for homebound older adults
This study is testing if a virtual reality (VR) headset or video interaction can give caregivers a short break while the older adult they care for stays safe at home. It aims to reduce caregiver stress and improve well-being for both of you.
Hong Kong, 香港島Ages 18 years+ - NCT06964399Recruiting
Reminiscence therapy for older adults
This study tests whether reminiscence therapy (looking back on positive memories) helps improve well-being in older adults. It may be a good fit if you are 65 or older and free from serious mental health issues or dementia.
ElâzığAges 65–100 - NCT06948136RecruitingPhase 1
THC effects in older adults trial
This trial studies how a single dose of THC (the active ingredient in cannabis) affects older adults. It aims to understand the effects in this age group, which may help guide safe use.
West Haven, ConnecticutAges 21 years+ - NCT06002477RecruitingEarly Phase 1
Attention study in sickle cell disease
This trial tests a medication to see if it can improve attention in people with sickle cell disease. It may help with thinking and focus.
Nashville, TennesseeAges 55 years+ - NCT07623785Recruiting
Beef and Brain Health in Older Adults
This study looks at whether eating lean beef and dairy products daily affects brain health markers in people 65 and older. Researchers will track blood, urine, and other samples to see if beef consumption influences how your brain functions at the molecular level.
Brookings, South DakotaAges 65 years+ - NCT02972008Recruiting
Looking for blood markers that predict complications after TAVI
This study enrolls older adults having a minimally invasive heart valve procedure (TAVI) to find “epigenetic” risk markers—signals in the body that may predict who is more likely to have complications during the procedure. If you qualify, your blood and/or samples may be studied to improve safety for future patients.
LilleAges 70 years+ - NCT03946930Recruiting
Study of memory decline in Alzheimer’s disease
This trial studies people diagnosed with Alzheimer’s disease who are at a moderate stage of decline. It likely involves cognitive (memory/thinking) testing and care-partner input to help track changes over time.
Hong KongAges 65–92 - NCT04700826RecruitingPhase 4
Preventing stroke, death, and memory decline in atrial fibrillation
This trial looks at ways to help people with atrial fibrillation lower their risk of stroke, premature death, and worsening memory. It may help by identifying which prevention approach works best for a broader community of patients.
Birmingham, West MidlandsAges 55–73 - NCT05048680Recruiting
Breathing low-oxygen training to support brain blood flow in seniors
This study tests whether brief “low-oxygen” conditioning can improve blood flow to the brain and overall cerebrovascular (brain blood vessel) health in older adults. It may help people who are generally less active, as long as they have no major medical or safety barriers for the training.
La Tronche, Auvergne-Rhône-AlpesAges 60–80 - NCT05130203Recruiting
Exergaming for long-term care residents and caregivers
This study tests a new “exergaming” activity—games that encourage movement—made for older adults in long-term care. It may help residents stay active and engaged, with participation also involving family, friends, or staff feedback.
TorontoAges 55 years+ - NCT05277558Recruiting
MRI and brain testing in teens at risk for type 2 diabetes
This study looks at brain health in teens with normal weight, overweight, or obesity who are at risk for type 2 diabetes. It may help researchers understand how weight and diabetes risk affect the brain, using MRI scans and learning/memory tests.
St Louis, MissouriAges 12–17 - NCT05339438Recruiting
Brain scan mapping before epilepsy surgery
This study uses a special MRI scan to map parts of the front-temporal brain in people with drug-resistant epilepsy who may need surgery. The goal is to better plan surgery by showing which brain areas are involved.
NancyAges 18 years+ - NCT05556395Recruiting
Study after stroke to help thinking and memory recovery
This trial looks at stroke patients who can show specific scan findings on an MRI, then uses thinking tests by phone to track cognitive (thinking and memory) changes. It may help researchers understand whether targeting brain blood-flow disruption can improve post-stroke cognition.
Baltimore, MarylandAges 18 years+ - NCT05592678Recruiting
Study brain and memory test changes in Alzheimer’s or mild issues
This study looks at how well people with Alzheimer’s disease (AD) or mild cognitive impairment (MCI) perform on standardized memory/brain tests. It may help researchers understand changes over time, and whether certain types of brain signals or test results track with the condition.
San Antonio, TexasAges 65–100 - NCT05629871Recruiting
Tracking sleep changes in early Alzheimer’s and thinking decline
This study looks at how sleep and wake patterns change in people with early Alzheimer’s, and whether these changes relate to memory and thinking decline. You may be asked to do questionnaires, sleep diaries, and possibly a diagnostic spinal fluid test (lumbar puncture) to measure biomarkers.
MontpellierAges 50–85 - NCT05649514Recruiting
Studying sleep problems in early Alzheimer’s risk patients
This study looks at sleep problems in people with mild Alzheimer’s disease and whether sleep measurements and questionnaires can help researchers understand early changes. You may be able to join if your diagnosis is mild and you can complete repeated sleep and thinking questionnaires with a family caregiver’s help.
Montpellier, HéraultAges 50–85 - NCT05822388Recruiting
Deep brain stimulation and memory changes in Parkinson’s
This study looks at whether deep brain stimulation (a surgical treatment for Parkinson’s disease) affects thinking and memory over time. It compares Parkinson’s participants to people without Parkinson’s to better understand what changes happen with treatment.
Charleston, South CarolinaAges 18 years+
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Common questions
- Are there clinical trials for cognitive decline?
- Yes. Clin2 currently lists 181 recruiting cognitive decline studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive decline trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive decline trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.