Clinical trials
Cognitive Decline clinical trials
Below are recruiting cognitive decline clinical trials, each written for real people, not researchers. We’re tracking 172 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06703320Recruiting
Virtual reality pathfinding study for stroke recovery
This study uses a virtual reality pathfinding game to see how your brain activates after a stroke. It may help doctors understand how to improve recovery.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT06703307Recruiting
Brain markers for stroke-related thinking changes
This study uses a special brain scanning technique (fNIRS) to look for markers that show how stroke affects thinking. Both people who have had a stroke and healthy volunteers can join.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT06648707Recruiting
Thinking and moving: a study for older adults
This study tests if combining physical and mental exercises can help prevent memory loss in older adults. If you are 65 or older and can join activities at a community center, this might be for you.
Hong KongAges 65 years+ - NCT06730711Recruiting
Blood pressure and stroke-related thinking changes
This study looks at how blood pressure after a stroke might affect your thinking and memory. It uses information from your hospital stay and follow-up visits to see if there is a link.
Chongqing, Chongqing MunicipalityAges 18–90 - NCT07568093Recruiting
Music therapy to reduce agitation after abdominal surgery
This study tests whether listening to music after abdominal surgery can help reduce agitation and anxiety during recovery. Researchers will compare patients who receive music therapy with standard care to see if it improves comfort and outcomes.
Hanover, Lower SaxonyAges 18 years+ - NCT07465497Enrolling by invitation
Preventing Chemo Brain with Prebiotics and Synbiotics
This trial tests whether taking a special blend of prebiotics and synbiotics (friendly bacteria and food for them) can help prevent or reduce memory and thinking problems that sometimes happen during chemotherapy for breast cancer.
Zapopan, JaliscoAges 18 years+ - NCT07399418Recruiting
Tracking risk in integrated Alzheimer's diagnosis
This study is looking for people with or at risk for Alzheimer's disease and their caregivers. It aims to track risk factors and improve diagnosis using a combination of tests and tools.
Montescano, Pavia, ItalyAges 50 years+ - NCT07389213Recruiting
Can brain stimulation and hearing aids slow memory loss in older adults with hearing loss?
This trial tests whether a non-invasive brain stimulation technique (rTMS) combined with hearing aids can help slow down thinking and memory decline in older adults who have age-related hearing loss.
Guangzhou, GuangdongAges 50–85 - NCT06832761Recruiting
Lifestyle help for people with early memory concerns
This trial tests whether a lifestyle program can help people with mild memory problems (subjective cognitive decline or mild cognitive impairment) who also have at least two things that increase their risk for dementia, like high blood pressure or lack of exercise. If you're 50 or older and have these memory issues and risk factors, you may be able to join.
AmsterdamAges 50 years+ - NCT07353424Recruiting
Salicornia extract for memory after a small stroke
This study tests whether a polyphenol-rich extract from a salt-tolerant plant called Salicornia can slow memory decline in people who have had a lacunar stroke. It compares the extract to the usual care you would receive.
SevilleAges 40–90 - NCT07329647Recruiting
Brain nutrition study for cognitive decline
This trial tests whether a nitrate-rich food supplement can improve blood flow in the brain and help thinking and memory. It is for people with small vessel disease in the brain or diabetes who are at risk for cognitive decline.
CoimbraAges 18 years+ - NCT07324330Recruiting
Slowing cognitive decline with exercise in iRBD
This study tests if increasing physical activity can help slow down cognitive (thinking) decline in people with iRBD, a sleep disorder that often leads to Parkinson's or dementia. You'll use a smartphone and a FitBit to track your activity and receive coaching.
Bonn, North Rhine West-FaliaAges 50–80 - NCT06068582Recruiting
Keep your memory sharp and stay at work with MS
This study tests a program of physical and mental exercises designed to slow down memory and thinking problems in people with multiple sclerosis, and help them stay employed longer.
AmsterdamAges 18–67 - NCT06914284Recruiting
Apathy and thinking changes in older adults with bipolar disorder
This study looks at whether apathy and certain brain markers can help predict memory and thinking problems in people over 70 with bipolar disorder. If you are 70-85, have bipolar disorder, and are currently stable (no recent mood episodes), you may be able to join.
Rennes, Ile Et VilaineAges 70–85 - NCT07217912RecruitingPhase 2
Study of daridorexant to prevent confusion after heart surgery
This trial tests whether a sleep medication called daridorexant can help prevent delirium (sudden confusion) in older adults after heart surgery. You must be 60 or older and having a specific type of heart operation.
Rochester, New YorkAges 60 years+ - NCT07160673Recruiting
Tech-based caregiver break for homebound older adults
This study is testing if a virtual reality (VR) headset or video interaction can give caregivers a short break while the older adult they care for stays safe at home. It aims to reduce caregiver stress and improve well-being for both of you.
Hong Kong, 香港島Ages 18 years+ - NCT07151365Recruiting
Plant-based diets and healthy aging study
This study looks at how a plant-based diet might help people age in a healthy way. It is for adults 40 and older who are part of the Tzu Chi Foundation and are joining a health checkup program.
Dalin, ChiayiAges 40 years+ - NCT04700826RecruitingPhase 4
Preventing stroke, death, and memory decline in atrial fibrillation
This trial looks at ways to help people with atrial fibrillation lower their risk of stroke, premature death, and worsening memory. It may help by identifying which prevention approach works best for a broader community of patients.
Birmingham, West MidlandsAges 55–73 - NCT07044596Recruiting
Non-invasive brain stimulation to slow cognitive decline
This study tests whether a gentle, non-invasive electrical stimulation can help slow memory loss or thinking problems. It is looking for healthy volunteers and people who have had a mild traumatic brain injury within the past year.
Madison, WisconsinAges 20–85 - NCT07036328Recruiting
Magnetic brain stimulation to slow memory loss in Alzheimer's
This study tests whether a noninvasive magnetic brain stimulation treatment can slow down cognitive decline in people with early Alzheimer's disease. You'll receive daily sessions over several weeks, and the goal is to see if it helps preserve memory and thinking skills.
AmsterdamAges 50–85 - NCT06960096Recruiting
Cognitive decline after deep brain stimulation: an MRI study
This study uses MRI scans to see how deep brain stimulation (DBS) affects thinking and memory in people with Parkinson's disease. It may help researchers understand why some people experience cognitive changes after DBS surgery.
Charleston, South CarolinaAges 18 years+ - NCT06948136RecruitingPhase 1
THC effects in older adults trial
This trial studies how a single dose of THC (the active ingredient in cannabis) affects older adults. It aims to understand the effects in this age group, which may help guide safe use.
West Haven, ConnecticutAges 21 years+ - NCT05649514Recruiting
Studying sleep problems in early Alzheimer’s risk patients
This study looks at sleep problems in people with mild Alzheimer’s disease and whether sleep measurements and questionnaires can help researchers understand early changes. You may be able to join if your diagnosis is mild and you can complete repeated sleep and thinking questionnaires with a family caregiver’s help.
Montpellier, HéraultAges 50–85 - NCT06896825Recruiting
Staying active with social support and stress relief
This study tests whether a program that combines social support and stress management can help older adults who live alone become more physically active. You'll use a smartphone to track your activity and get support from others.
Phoenix, ArizonaAges 60 years+
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Common questions
- Are there clinical trials for cognitive decline?
- Yes. Clin2 currently lists 172 recruiting cognitive decline studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive decline trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive decline trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.