Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 900 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06805045Recruiting
Image-guided surgery for rectal cancer
This trial uses special imaging to guide surgery for rectal cancer. It studies whether detailed scans taken before surgery can help doctors remove the cancer more precisely.
BolognaAges 18–80 - NCT06812728RecruitingPhase 2
Chemo and radiation before surgery for advanced rectal cancer
This trial tests giving a strong chemotherapy combination (FOLFIRINOX) followed by radiation before surgery for locally advanced rectal cancer. If you have stage 3 or high-risk stage 2 rectal cancer that has not spread, this approach may shrink the tumor and improve outcomes.
Shibīn al Kawm, MenoufiaAges 18–70 - NCT06831669Recruiting
Predicting rectal cancer treatment response and side effects
This study uses metabolomics (analysis of small molecules in your body) to predict how well your rectal cancer will respond to treatment and whether you may experience side effects. It focuses on patients receiving total neoadjuvant therapy (treatment before surgery).
Guishan, TaoyuanAges 20 years+ - NCT06839105RecruitingPhase 1
Testing AWT020 for advanced cancers
This study tests an experimental drug called AWT020 in people with advanced cancers that have either stopped responding to standard treatments or aren't candidates for them. The goal is to see if AWT020 is safe and tolerable across several cancer types such as lung cancer, melanoma, colorectal cancer, kidney cancer, and others.
Fuzhou, FujianAges 18 years+ - NCT06854679Recruiting
MRI-guided radiation for rectal cancer
This trial tests a new way of giving radiation therapy for rectal cancer, using MRI scans to aim the radiation more precisely. It's for people who need chemotherapy and radiation before surgery, and it aims to make treatment more effective while reducing side effects.
Sutton, SurreyAges 18 years+ - NCT06857773RecruitingPhase 3
Combined pump therapy and chemo for liver-only colorectal cancer
This trial tests a treatment approach where you receive chemotherapy directly into your liver through a surgically placed pump, combined with standard systemic chemotherapy (given through a vein). The goal is to shrink liver tumors enough so they can be removed later with surgery. It is for people whose colorectal cancer has spread only to the liver and has not been treated before.
AmsterdamAges 18 years+ - NCT06946615RecruitingPhase 1
Claudin18.2 cell therapy for advanced colorectal cancer
This study tests a new treatment using your own immune cells (called CAR-T and CAR-DC) that are engineered to attack cancer cells with a specific protein (Claudin18.2). It is for people with advanced colorectal cancer who have exhausted standard treatments.
Hangzhou, ZhejiangAges 18–70 - NCT06961149Recruiting
Comparing light vs dye spray for colon polyp detection
This study compares two methods used during colonoscopy to help find polyps in the colon. It tests whether a special light technique (linked-color imaging) or a dye spray (indigo carmine) works better for spotting adenomas, which are growths that can turn into cancer. If you are at higher risk for colorectal adenomas, this trial may help improve detection.
Jinan, ShandongAges 45–85 - NCT06964438Recruiting
Post-surgery electrical muscle stimulation study for colorectal or stomach cancer
This trial tests if using a mild electrical device on your legs after surgery can help you recover faster. It is for people with colorectal or stomach cancer who are having curative abdominal surgery.
Derby, DerbyshireAges 18 years+ - NCT06965166Recruiting
Better CT scans for staging rectal cancer
This study tests a new, more detailed type of CT scan (called photon-counting CT) to see if it can better show how far rectal cancer has grown or spread. If you are already getting standard scans to stage your cancer, this study adds an extra CT scan with contrast dye to get clearer pictures.
Rochester, MinnesotaAges 18–99 - NCT06976710Recruiting
Improving communication before colon or rectal cancer surgery
This trial is testing a way to improve communication between you and your surgical team before colon or rectal cancer surgery. It's for adults having major surgery that aims to cure their cancer.
Coffs Harbour, New South WalesAges 18 years+ - NCT07091032Recruiting
Building connections for better health
This study tests if helping people address obesity, cancer screenings, or mental health struggles can improve their overall health. You may qualify if you have obesity, are behind on colon or cervical cancer screening, or have depression or anxiety.
Boston, MassachusettsAges 18–75 - NCT07094204RecruitingPhase 1
A study of ASP5834 for adults with solid tumors and KRAS mutations
This trial is testing a new drug called ASP5834 for people with advanced solid tumors that have a specific change in the KRAS gene. The study will find the best dose and see if it helps shrink tumors.
Santa Monica, CaliforniaAges 18 years+ - NCT07108348Recruiting
ADAR1 levels in rectal cancer
This study looks at a protein called ADAR1 in rectal cancer tissue. It aims to see how ADAR1 levels might be related to the cancer and help doctors understand the disease better.
Konya, MeramAges 18–90 - NCT07291180Recruiting
Personalized heated chemo for advanced appendix or colon cancer
This study tests a personalized way to deliver heated chemotherapy directly into the belly during surgery for advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if tailoring the chemo drugs to your tumor can improve outcomes.
New Haven, ConnecticutAges 18–81 - NCT07314996Recruiting
Laparoscopic vs. open surgery for colon cancer with belly fat
This trial compares laparoscopy (minimally invasive) and open surgery for treating colon cancer in people with extra belly fat around internal organs (visceral obesity). The goal is to see which approach gives better recovery and outcomes.
Hangzhou, ZhejiangAges 18–75 - NCT07369531Recruiting
Stoma-free survival after new anal-sparing surgery for low rectal cancer
This study compares a two-stage surgical technique (Turnbull-Cutait pull-through) to standard surgery for people with low rectal cancer. The goal is to see which approach helps more patients avoid a permanent stoma (bag) after surgery.
Changchun, JilinAges 18–75 - NCT07372300RecruitingPhase 3
Heat therapy plus standard care for advanced rectal cancer
This trial tests whether adding modulated electro-hyperthermia (a gentle heat treatment) to standard therapy (radiation and chemotherapy) before surgery helps control locally advanced rectal cancer. It is for people whose cancer has not spread to other parts of the body.
Chiayi City, Dalin TownshipAges 20 years+ - NCT02246634Recruiting
MRI screening to find liver metastases in bowel cancer
This study checks whether a special MRI scan (DW-MRI) can spot liver metastases early in people with high-risk colorectal cancer. Finding metastases sooner may help doctors choose the right treatment path.
Macclesfield, CheshireAges 16 years+ - NCT02885753RecruitingPhase 3
Liver-only metastatic colon cancer trial using targeted chemo
This Phase 3 trial tests different ways to deliver chemotherapy for colon cancer that has spread only to the liver (with limited possible tiny lung spots). It looks at whether the treatment plan improves outcomes compared with another chemotherapy approach, using oxaliplatin and LV5FU2 (with or without irinotecan) plus an added targeted medicine.
BrusselsAges 18 years+ - NCT03179540Recruiting
Watch-and-wait treatment after rectal cancer radiation
This trial looks at a “non-surgery” approach for some people with locally advanced rectal cancer who respond very well to radiation plus chemotherapy. If your cancer shows a complete clinical response on follow-up checks, the study may help you avoid an immediate major operation while closely monitoring you.
Toronto, OntarioAges 18 years+ - NCT07417488RecruitingPhase 1
Vaccine therapy for advanced colorectal and small bowel cancer
This trial tests a vaccine therapy for people with advanced colorectal or small bowel cancer that has spread or can't be removed. The vaccine targets a protein found on cancer cells to help your immune system fight the cancer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07427537Recruiting
Studying nerve damage from chemotherapy in colorectal and lung cancer patients
This study looks for small molecules in the blood that might predict nerve damage caused by certain chemotherapies. If you have colorectal or lung cancer and are starting a specific chemo plan, this trial could help researchers understand why some people get nerve problems and others don't.
Clermont-FerrandAges 18 years+ - NCT07589205RecruitingPhase 1
Testing IBI3028 for Advanced Solid Tumors
This early-stage trial tests a new drug called IBI3028 in people with advanced cancers that cannot be removed by surgery or have spread. The study aims to find the right dose and understand how the drug works in your body.
Tianjin, Tianjin MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 900 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.