Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 898 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05943444Recruiting
Compares two ways to preserve bowel function after rectal surgery
This trial compares two surgical techniques to see which one better preserves anal function after surgery for low rectal cancer. If you may be eligible for anal-preserving surgery, it may help your care team choose the approach that best protects bowel control.
Guangzhou, GuangdongAges 18–75 - NCT05970302RecruitingPhase 2
XELOX, bevacizumab, and immunotherapy for metastatic colon cancer
This Phase 2 trial studies a combination treatment (XELOX plus bevacizumab plus an immunotherapy drug) for people with metastatic colon cancer that has certain lab features (MSS/pMMR and RAS-mutated). It aims to see how well the treatment works as a first treatment when the cancer cannot be removed with surgery.
BeijingAges 18 years+ - NCT05984576Recruiting
Chemo and radiation for recurrent rectal cancer after prior pelvic radiation
This study looks at combining total neoadjuvant therapy (chemotherapy and radiation) for rectal cancer that has come back in the pelvis after earlier radiation. It aims to see if this treatment approach can help control the disease and improve outcomes in patients with limited spread that can potentially be removed or treated.
RomeAges 18 years+ - NCT05984875Recruiting
Immune system study for ovarian cancer
This study looks at how the immune system works in people with epithelial ovarian cancer. It aims to understand the immune landscape around the tumor, which could lead to better treatments in the future.
BellinzonaAges 18 years+ - NCT06002789RecruitingPhase 2
PD-1 immunotherapy with or without chemo before surgery for colorectal cancer
This trial tests a medicine called PD-1 (a type of immunotherapy that helps your immune system fight cancer), sometimes with chemotherapy, before surgery for a certain type of colorectal cancer. It is for people whose tumors have a specific DNA repair problem (dMMR or MSI-H) and whose cancer has not spread to distant organs.
Guangzhou, GuangdongAges 18–80 - NCT06017583RecruitingPhase 3
Chemo plus immunotherapy and targeted radiation for advanced rectal cancer
This trial tests whether combining chemotherapy, immunotherapy (PD-1 inhibitor), and a precise type of radiation can help shrink locally advanced rectal cancer before surgery. It aims to improve treatment success and reduce side effects.
Nanning, GuangxiAges 18–70 - NCT06055439RecruitingPhase 1/Phase 2
CAR T cell therapy for GI cancers
This trial tests a new type of immunotherapy called CAR T cells that target a protein (CDH17) found on certain stomach, colon, and rectal cancers. It's designed for people whose cancer has spread and has been treated before.
Atlanta, GeorgiaAges 18–85 - NCT06220045Recruiting
Comparing two meshes for closing abdominal incisions in urgent colon surgery
This trial tests two different mesh types used to close the midline incision after urgent colorectal surgery, to see which one better prevents hernias and wound infections.
GironaAges 18 years+ - NCT06220058Recruiting
Preventing hernias after emergency colorectal surgery
This study compares two ways of closing the belly after emergency colorectal surgery to see which one better prevents hernias. If you need this type of surgery, you may be able to join.
Girona, CataloniaAges 18 years+ - NCT06226857RecruitingPhase 3
Anti-EGFR for left-sided, RAS wild-type metastatic colorectal cancer
This trial tests whether anti-EGFR therapy works better for people with left-sided colorectal cancer that has spread, whose tumors do not have certain gene mutations (RAS wild-type). It is for those who have not yet had treatment for metastatic disease.
MoscowAges 18–99 - NCT06252142Recruiting
Monitoring after rectal cancer treatment
This study looks at whether careful monitoring (watch and wait) is a good option for people with rectal cancer who have already had certain treatments. It aims to see if this approach can help avoid major surgery.
Mumbai, MaharashtraAges 18–90 - NCT06325982Recruiting
Preventing rectal injury from radiation with a medicated enema
This trial tests whether a medicated enema can help prevent radiation damage to the rectum during pelvic radiotherapy. It may be a good option if you are starting radiation to the pelvis or rectum and are otherwise in good health.
Xiamen, FujianAges Any age - NCT06442215Recruiting
Choosing the best surgery for rectal cancer
This trial compares surgical techniques for removing rectal cancer (anterior resection). It looks at patients with adenocarcinoma who are scheduled for surgery to find the best approach.
GironaAges 18 years+ - NCT06447012Recruiting
AI tool for diagnosing colon polyps
This trial uses artificial intelligence to help better identify polyps during a colonoscopy, which could improve diagnosis and treatment decisions.
LondonAges 18 years+ - NCT06569368RecruitingPhase 2
Metronidazole with rectal cancer treatment
This trial tests adding the antibiotic metronidazole to standard pre-surgery therapy for locally advanced rectal cancer. The goal is to see if changing the bacteria in your gut can make the cancer treatment work better.
Houston, TexasAges 18 years+ - NCT06576986Recruiting
Can a supplement prevent mouth sores during chemo?
This trial tests whether a special supplement (synbiotic) can prevent mouth sores caused by chemotherapy in people with colorectal cancer. It's for those starting treatment who live in or near Belo Horizonte, Brazil.
Belo Horizonte, Minas GeraisAges 18 years+ - NCT06594887Recruiting
Rectal spacer use during proton therapy for prostate cancer
This trial tests how well a rectal spacer works when you get proton beam therapy for prostate cancer. The spacer is a gel placed between your prostate and rectum to protect healthy tissue.
Somerset, New JerseyAges 18 years+ - NCT06620627Recruiting
Blood test for early cancer detection before colonoscopy
This study is testing a new blood test that might help find cancer early. If you are 40 or older and planning a routine screening colonoscopy, you may be able to join. You will give a blood sample before the colonoscopy, and the researchers will see if the test can detect signs of cancer.
Austin, TexasAges 40 years+ - NCT06631443Recruiting
Asian Watch-and-Wait Study for Rectal Cancer
This study is for people with rectal cancer who have had treatment like radiation or chemo and their tumor has disappeared or nearly disappeared. Instead of surgery right away, doctors will closely monitor the cancer with regular check-ups to make sure it stays gone.
Mumbai, MaharashtraAges 18 years+ - NCT06682650Recruiting
Colorectal cancer screening tool for Spanish-speaking communities
This study tests if a new tool can help clinics in Spanish-speaking communities get more people screened for colorectal cancer. If you are an adult 45–75 who is due for screening and get care at a participating clinic, you may be eligible.
Aurora, ColoradoAges 45–75 - NCT04184973Recruiting
Testing a colon bypass device during colorectal cancer surgery
This trial studies a device (CG-100) placed inside the bowel to see if it can improve safety and outcomes during surgery for colorectal cancer. You would be asked to follow extra study check-ins after your operation, and the team would monitor whether the device works as intended.
Irvine, CaliforniaAges 22–70 - NCT06750094RecruitingPhase 3
Study of amivantamab plus FOLFIRI in colorectal cancer
This trial tests adding amivantamab to standard FOLFIRI chemotherapy for people with certain types of colorectal cancer that have already been treated once. It aims to see if this combination works better than another common treatment (cetuximab or bevacizumab plus FOLFIRI).
Chandler, ArizonaAges 18 years+ - NCT06769061Recruiting
Acupuncture for Chemo Nerve Pain in Gynecologic Cancers
This study tests whether acupuncture can help reduce nerve pain, numbness, or tingling in hands and feet caused by chemotherapy for gynecologic cancers. You may join if you finished certain chemo at least 3 months ago and still have these symptoms.
Hong KongAges 18 years+ - NCT06770270RecruitingPhase 2
Immunotherapy with radiation and chemo before rectal cancer surgery
This trial tests adding an immunotherapy drug (pucotenlimab) to standard radiation and chemotherapy before surgery for locally advanced rectal cancer. The goal is to see if this combination can shrink the tumor more effectively and improve outcomes.
Hangzhou, ZhejiangAges 18–75
Hear when a new Colorectal (Colon or Rectal) Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 898 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.