Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 900 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07289568Enrolling by invitation
Comparing surgery types for splenic flexure cancer
This study looks at two types of surgery for cancer in a part of the colon called the splenic flexure. It compares removing just the affected section (segmental colectomy) with removing a larger portion (extended hemicolectomy) to see which has better outcomes.
Istanbul, IstanbulAges 18–80 - NCT06957236Enrolling by invitation
NICE Procedure for Benign Colon Disease
This trial tests a new minimally invasive surgery called the NICE procedure for treating benign left-sided colon diseases like diverticulitis or benign polyps. It aims to see if this approach leads to fewer infections and better recovery compared to standard surgery.
Houston, TexasAges 18 years+ - NCT05652361Recruiting
AI guidance system for robotic rectal cancer surgery
This trial tests a machine-learning (AI) system that may help guide surgeons during robotic rectal cancer operations. It’s meant to support safer, more accurate surgery while comparing outcomes to standard surgical guidance.
Dresden, SaxonyAges 18 years+ - NCT07786818Recruiting
Colorectal cancer screening marker study
This study looks for markers in stool and saliva that might indicate the presence of precancerous growths in the colon. If you are scheduled for a colonoscopy, you may be able to participate by providing samples beforehand.
Bothell, WashingtonAges 18 years+ - NCT07429110Recruiting
ColoSeal device study for rectal cancer surgery patients
This study tests a device called ColoSeal that protects the connection made during rectal cancer surgery. It is for patients who are having surgery to remove the tumor and reattach the bowel, and who also need a temporary ostomy.
Orlando, FloridaAges 22–75 - NCT06645015Recruiting
AI tool for colon or rectal cancer surgery decisions
This trial tests an AI-based platform to help plan the best surgery for people with colon or rectal cancer. It aims to improve decision-making by both doctors and patients.
AalborgAges 18 years+ - NCT05663775RecruitingPhase 2
Mesalamine to prevent bowel inflammation after melanoma immunotherapy
This study tests whether taking mesalamine can prevent colitis (bowel inflammation) in people with advanced melanoma who are treated with ipilimumab plus nivolumab. It may help reduce dangerous stomach or bowel side effects from this cancer treatment.
Edmonton, AlbertaAges 18 years+ - NCT04220905Recruiting
Watching outcomes after removing large colon and duodenal polyps
This observational study follows people who have large polyps in the colon or duodenum that are removed during endoscopy. It aims to understand how safe and effective this approach is, and what outcomes patients have afterward.
White River Junction, VermontAges 18 years+ - NCT03692429RecruitingPhase 1
Testing new immune cells plus chemo for advanced colon cancer
This Phase 1 study tests CYAD-101, an immune-cell treatment made from donor T-cells, given with standard chemotherapy. It is for people with colon or rectal cancer that has spread and has not responded to prior treatments.
Tampa, FloridaAges 18 years+ - NCT06317727Recruiting
Pulsed field ablation for removing colon polyps
This study tests a new way to remove colon polyps using short bursts of energy (pulsed field ablation) instead of standard methods. It may help people with polyps in the lower part of the colon that are not too large or complex.
LondonAges 18 years+ - NCT04815694Recruiting
MRI-guided radiotherapy for rectal cancer
This trial tests whether using MRI scans to guide radiotherapy can improve treatment for people with a certain type of rectal cancer. It focuses on patients whose tumors have not spread to other parts of the body and who have specific tumor features seen on MRI.
Roma, RomaAges 18 years+ - NCT07020247RecruitingPhase 3
Personalized radiation plus chemo with or without immunotherapy for rectal cancer
This trial tests adding immunotherapy to standard radiation and chemotherapy for patients with locally advanced rectal cancer. The goal is to see if a personalized approach improves outcomes while sparing more normal tissue.
Chengdu, SichuanAges 18 years+ - NCT07389863Recruiting
Sexual health after rectal cancer treatment
This study looks at the long-term effects of rectal cancer treatment on gynecological and sexual health. It aims to understand how women recover after treatment, helping improve future care and support.
RouenAges 18–60 - NCT07346248Enrolling by invitation
Complications after pre-surgery treatment for advanced rectal cancer
This study looks at complications that happen after surgery in patients with advanced rectal cancer who got radiation or chemo-radiation before their operation. Researchers want to learn how different pre-surgery treatments affect recovery.
Rozzano, MilanAges 18 years+ - NCT07230639RecruitingPhase 2
Shorter radiation with chemo and immunotherapy for high-risk colon cancer
This trial tests a shorter course of radiation combined with chemotherapy and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of high-risk colon cancer that has not spread. The goal is to see if this approach can shrink the tumor before surgery and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT07448077RecruitingPhase 2
Short radiation with immunotherapy for rectal cancer
This trial tests a combination of short-course radiation, chemotherapy, and an immunotherapy drug (Enlonstobart) for patients with a specific type of rectal cancer called pMMR. It aims to see if this approach can shrink tumors before surgery and improve outcomes.
Shijiazhuang, HebeiAges 18 years+ - NCT06015607Recruiting
Testing a new tool for colon polyp removal
This trial tests a new device to help doctors remove larger, non-cancerous polyps from the colon during a colonoscopy. It may make the procedure easier and more effective for eligible patients.
Cleveland, OhioAges 21 years+ - NCT07401264Recruiting
Colorectal Polyp Image Collection Study
This trial collects video and images of colorectal polyps during a standard colonoscopy. It helps doctors learn more about polyps 10 mm or larger, which may be more likely to be cancerous.
LeuvenAges 18 years+ - NCT06656312Recruiting
EndoAim AI for colon polyp detection
This study tests an artificial intelligence (AI) system called EndoAim that helps doctors find polyps during a colonoscopy. It is for people having a routine colonoscopy with an Olympus endoscope.
Taichung, North Dist.Ages 20 years+ - NCT07007598Recruiting
Preventing bleeding after polyp removal with clips
This trial tests whether placing small clips at the site of polyp removal in the colon can reduce bleeding in patients who take blood thinners afterwards.
Schwerin, Mecklenburg-VorpommernAges 18 years+ - NCT07674732RecruitingPhase 2
Shorter radiation with immunotherapy for rectal cancer
This trial tests a shorter course of radiation followed by a combination of chemotherapy, immunotherapy, and a targeted drug (bevacizumab) for locally advanced rectal cancer that is mismatch repair proficient (pMMR) or microsatellite stable (MSS). The goal is to see if this approach can shrink the tumor enough for surgery while avoiding more extensive radiation.
Guangzhou, GuangdongAges 18–75 - NCT07283939Recruiting
Testing a tool to adjust chemo doses and reduce treatment delays
This trial tests a computer algorithm called PAGODA that helps doctors adjust chemotherapy doses for people with gastrointestinal cancers. The goal is to prevent unplanned treatment delays while keeping the treatment effective.
Fairbanks, AlaskaAges 18 years+ - NCT07732894Recruiting
Exercise and Guided Imagery for Bowel Symptoms After Cancer Surgery
This study tests if combining gentle aerobic exercise with guided imagery (a relaxation technique using your imagination) can help improve bowel control and reduce symptoms after rectal cancer surgery.
IstanbulAges 18–65 - NCT07730541Recruiting
Special MRI for rectal cancer before treatment
This trial uses a special MRI technique to help doctors better understand rectal cancer before treatment. It is for people who will receive chemotherapy and radiation before surgery.
TaoyuanAges 20 years+
Hear when a new Colorectal (Colon or Rectal) Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 900 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.