Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 867 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02292641Recruiting
MRI study for repeat pelvic colorectal cancer
This study uses a special MRI to help understand and stage colorectal cancer that has come back in the pelvis. The goal is to improve how doctors make treatment decisions after previous surgery.
OsloAges 16 years+ - NCT02704520Recruiting
MRI scoring test for rectal cancer response to treatment
This study looks at how an MRI “score” (mrTRG) matches how well locally advanced rectal cancer shrinks after pre-surgery chemotherapy and radiation. The goal is to use MRI results to better predict treatment response and guide care.
Aberdeen, AberdeenshireAges 16 years+ - NCT06656312Recruiting
EndoAim AI for colon polyp detection
This study tests an artificial intelligence (AI) system called EndoAim that helps doctors find polyps during a colonoscopy. It is for people having a routine colonoscopy with an Olympus endoscope.
Taichung, North Dist.Ages 20 years+ - NCT07674732RecruitingPhase 2
Shorter radiation with immunotherapy for rectal cancer
This trial tests a shorter course of radiation followed by a combination of chemotherapy, immunotherapy, and a targeted drug (bevacizumab) for locally advanced rectal cancer that is mismatch repair proficient (pMMR) or microsatellite stable (MSS). The goal is to see if this approach can shrink the tumor enough for surgery while avoiding more extensive radiation.
Guangzhou, GuangdongAges 18–75 - NCT07651553Recruiting
Transanal vs. Robotic Surgery for Rectal Cancer
This trial compares two surgical approaches to remove rectal cancer while preserving bowel function. Researchers want to see which method—performed through the anus or with robotic assistance—leads to better outcomes and quality of life.
Guangzhou, GuangdongAges 18–75 - NCT07646639RecruitingPhase 2
Radiation, chemotherapy, and immunotherapy for advanced rectal cancer
This study tests a combination of radiation therapy, chemotherapy drugs (capecitabine and oxaliplatin), and two types of immunotherapy (a PD-1 blocker and IL-2) for locally advanced rectal cancer. The goal is to see if this combination helps shrink tumors and improve outcomes before surgery.
Nanjing, JiangsuAges 18–70 - NCT06126419Recruiting
High-dose insulin for liver function after surgery
This trial tests if high-dose insulin can help your liver work better and heal faster after a major liver surgery for colorectal cancer that has spread to the liver.
Montreal, QuebecAges 18 years+ - NCT07607990Recruiting
Rectal Indomethacin to Prevent Catheter Discomfort After Prostate Surgery
This study tests whether a special suppository (indomethacin, a pain-relieving medication) placed in the rectum can reduce bladder catheter discomfort after laparoscopic prostate removal surgery. If it works, it could help patients recover more comfortably.
Hangzhou, ZhejiangAges 18–80 - NCT07567027Recruiting
Testing a spacing gel to improve prostate cancer freezing treatment
This trial tests whether a special gel placed between the prostate and rectum improves the safety and effectiveness of cryoablation—a freezing treatment for prostate cancer. The gel aims to protect the rectum from cold damage during the procedure.
New York, New YorkAges 40–95 - NCT06542588RecruitingPhase 2
Short radiation plus chemo and immunotherapy for rectal cancer
This trial tests a combination of short-course radiation, chemotherapy, and two types of immunotherapy (HLX07 and Serplulimab) before surgery for advanced rectal cancer. It aims to see if this approach helps shrink tumors and improve outcomes.
Wuhan, HubeiAges 18–75 - NCT07549399RecruitingPhase 3
Radiation, Chemotherapy, and Immunotherapy for Rectal Cancer
This trial tests a combination of radiation, chemotherapy, and immunotherapy drugs before surgery for people with locally advanced rectal cancer. The goal is to shrink the tumor and improve outcomes for patients with higher-risk disease.
Guangzhou, GuangdongAges 18–75 - NCT07537998RecruitingPhase 2/Phase 3
Intestinal Fluid Recycling to Reduce Bowel Problems After Rectal Cancer Surgery
This trial tests a surgical technique that recycles intestinal fluids during rectal cancer surgery to help prevent bowel dysfunction and frequent bowel movements after surgery. If you've had mid-to-low rectal cancer removed and created a temporary opening (stoma), this study may help improve your quality of life.
Guangzhou, GuangdongAges 18–75 - NCT07501845Recruiting
Registry for MAASTRO rectal applicator treatment
This study collects data from people treated with a special rectal applicator for rectal cancer. The goal is to observe long-term outcomes and improve future treatments.
MaastrichtAges 18 years+ - NCT07486570Recruiting
Stenting to prevent leaks after colon surgery
This trial tests if placing a small mesh tube (stent) in a major artery can prevent leaks where the colon is reconnected during surgery. It may help people who have a blockage in that artery but no symptoms from it.
Emmen, DrentheAges 40 years+ - NCT07474103Recruiting
Chemo, radiation, and immunotherapy for high-risk rectal cancer
This trial tests a treatment plan that combines chemotherapy, radiation, and an immunotherapy drug before surgery for people with high-risk locally advanced rectal cancer. The goal is to see if this approach can improve outcomes.
WuhanAges 18–75 - NCT07467434Recruiting
Chemo before surgery for rectal cancer with liver spread
This trial tests if giving FOLFIRINOX chemotherapy first can improve outcomes for people with rectal cancer that has spread to the liver but can still be removed by surgery.
Le Kremlin-BicêtreAges 18 years+ - NCT07448077RecruitingPhase 2
Short radiation with immunotherapy for rectal cancer
This trial tests a combination of short-course radiation, chemotherapy, and an immunotherapy drug (Enlonstobart) for patients with a specific type of rectal cancer called pMMR. It aims to see if this approach can shrink tumors before surgery and improve outcomes.
Shijiazhuang, HebeiAges 18 years+ - NCT07403981Recruiting
Support program for new colorectal cancer patients
This study provides extra support and guidance to help you navigate your cancer care. It aims to improve your experience and outcomes.
Palo Alto, CaliforniaAges 18 years+ - NCT07401264Recruiting
Colorectal Polyp Image Collection Study
This trial collects video and images of colorectal polyps during a standard colonoscopy. It helps doctors learn more about polyps 10 mm or larger, which may be more likely to be cancerous.
LeuvenAges 18 years+ - NCT07389863Recruiting
Sexual health after rectal cancer treatment
This study looks at the long-term effects of rectal cancer treatment on gynecological and sexual health. It aims to understand how women recover after treatment, helping improve future care and support.
RouenAges 18–60 - NCT07371273RecruitingPhase 2
Comparing three surgeries for low rectal cancer
This trial tests three different surgical methods for rectal cancer located very close to the anal canal. The goal is to see which method works best in the short and long term while preserving anal function.
ShanghaiAges 18–75 - NCT07369830Recruiting
Probiotics for bowel function after rectal cancer surgery
This trial tests whether taking a probiotic supplement (Clostridium butyricum) can improve gut health and bowel function after surgery for very low rectal cancer. It may help patients who have a temporary ileostomy and are planning to have it reversed within 6 months.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07346248Enrolling by invitation
Complications after pre-surgery treatment for advanced rectal cancer
This study looks at complications that happen after surgery in patients with advanced rectal cancer who got radiation or chemo-radiation before their operation. Researchers want to learn how different pre-surgery treatments affect recovery.
Rozzano, MilanAges 18 years+ - NCT07291401RecruitingPhase 2
Study of radiation plus chemo and immunotherapy for rectal cancer
This trial tests a combination of radiation, chemotherapy (CAPOX), and immunotherapy (iparomlimab and tuvonralimab) given before surgery for locally advanced rectal cancer. The goal is to see if this approach can shrink tumors and improve outcomes.
Wuhan, HubeiAges 18–75
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 867 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.