Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 894 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07116668Enrolling by invitation
Colovac device study for colon surgery patients
This trial tests a device called Colovac that protects the connection made during colon surgery for cancer. It may help patients who need a temporary colostomy bag heal better.
Los Angeles, CaliforniaAges 22 years+ - NCT05877456Enrolling by invitation
Checking a polyp-removal scoring tool for doctors
This study tests and confirms a scoring tool (GPAT) that helps describe how well doctors perform polyp removal during endoscopy. It may help standardize training and assessment, which can improve consistency in care.
Ghent, GentAges 18–100 - NCT02107105Recruiting
Study how surgery affects life quality in rectal cancer
This trial studies how surgical treatment for rectal cancer affects patients’ quality of life and other day-to-day impacts. It may help doctors understand what to expect after surgery and how to better support patients.
Houston, TexasAges 18 years+ - NCT04703101RecruitingPhase 1
Short radiation plus chemo for stage II–III rectal cancer
This trial tests a short course of radiation therapy combined with chemotherapy for people with stage II or III rectal cancer. It’s designed to see whether this approach is safe and effective before or around cancer surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT03594630RecruitingEarly Phase 1
Watchful waiting then chemotherapy before surgery for rectal cancer
This trial studies whether a period of active surveillance (watching closely) and chemotherapy before surgery can improve outcomes for people with stage II–III rectal cancer. You would also receive standard chemo-radiation if you qualify, then proceed to surgery.
Houston, TexasAges 18 years+ - NCT05081024Recruiting
Blood test biomarker to help preserve organs in rectal cancer
This study looks at a blood test (ctDNA, a way to detect cancer DNA in the bloodstream) to help doctors choose treatment that may spare organs for people with stage II–III rectal cancer. You may be followed to see how well the blood test can guide treatment decisions.
Portland, OregonAges 18 years+ - NCT04117100Recruiting
Study registry for advanced endoscopy treatments
This study keeps a record of people who choose an advanced endoscopy procedure (like ESD, EMR, advanced polypectomy, POEM, or treatment for Zenker’s). It aims to learn about real-world outcomes and safety, which may help improve care for future patients.
Montreal, QuebecAges 18 years+ - NCT04798898Recruiting
RFA plus immune stimulation during liver surgery for colon cancer spread
This trial looks at whether using a heat-based treatment (RFA) to trigger the immune system before or during liver surgery can improve outcomes for people with colon cancer that has spread to the liver. It’s aimed at people who plan to have the liver tumors removed because they look treatable.
AarhusAges 18–99 - NCT05643859Recruiting
Fiber supplement study for bowel health and gut bacteria
This study tests whether adding a dietary fiber supplement can change the bacteria in your colon (gut microbiome). You may be asked to take the fiber supplement during evaluation for a non-cancer rectal condition.
Portland, OregonAges 18 years+ - NCT06906952Enrolling by invitation
Robotic surgery through the anus vs. standard robotic surgery for rectal cancer
This trial compares two robotic surgery methods for high rectal and sigmoid colon cancer—one that removes the tumor through the anus (NOSES-IV) and the traditional assisted approach. It aims to see which way may lead to better recovery.
NanchangAges 18–80 - NCT07541924Recruiting
Image-Guided Colonoscopy: Patient Experience and Doctor Efficiency
This study tests whether using CT scan images to guide doctors during colonoscopy (a camera exam of your colon) improves how well the procedure goes and reduces doctor stress. You'll answer questions about your experience before and after the procedure.
Beijing, Beijing MunicipalityAges 18–80 - NCT06931808Enrolling by invitationPhase 4
Fecal transplant with chemo, radiation, and immunotherapy for advanced colon cancer
This study tests a combination of fecal microbiota transplant, chemotherapy, radiation, and immunotherapy (sintilimab) for people with locally advanced rectal cancer. The goal is to see if this approach improves treatment outcomes.
Ningbo, ZhejiangAges 18–75 - NCT06197425RecruitingPhase 3
Extra chemotherapy after surgery for colorectal cancer with positive ctDNA
This trial tests whether giving more chemotherapy can help people who still have cancer DNA in their blood after surgery and standard chemotherapy for colorectal cancer. The goal is to prevent the cancer from coming back.
DijonAges 18–80 - NCT03001362Recruiting
Wait-and-see treatment for people with rectal cancer
This study tests a “wait-and-see” approach instead of immediate surgery for certain rectal cancers, aiming to avoid unnecessary operations. It may help people who are medically able to stay under close monitoring and only have surgery if needed.
Montreal, QuebecAges 18–90 - NCT05038358Recruiting
Study of immune and chemo resistance in colorectal tumors
This study looks at how the immune system around a colorectal tumor relates to resistance to chemotherapy. You may be able to join if you are having surgery soon for colorectal cancer and have not yet had chemotherapy before surgery.
GrenobleAges 18 years+ - NCT05197322RecruitingPhase 2
Pembrolizumab before surgery for MMR-deficient colon or rectal cancer
This trial tests pembrolizumab (an immunotherapy medicine) given before curative surgery in people with certain MMR-deficient colon or rectal cancers. It aims to shrink or control the cancer so surgery can be done more effectively, and to see if outcomes improve compared with standard care.
CambridgeAges 18 years+ - NCT05355363Recruiting
Check what happens after missed colon follow-up for colon polyps
This study looks at the risk of new or advanced colon findings in people who had certain colon polyp results, but then did not get the recommended follow-up colonoscopy on time. It may help doctors fine-tune how urgently different patients need repeat colon checks.
Montreal, QuebecAges 45–80 - NCT05482516RecruitingPhase 3
Testing blood test–guided treatment for GI cancers in remission
This Phase 3 study tests whether giving treatment based on a positive blood test for “minimal cancer signals” (ctDNA) can help people with certain GI cancers stay cancer-free longer. It focuses on people who have finished curative-intent therapy and currently have no visible disease on scans, but their blood test is still positive.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06376565Recruiting
Improving colonoscopy follow-up for high-risk polyps
This study aims to understand why some people return for a follow-up colonoscopy after having high-risk colon polyps and to find ways to improve the process. It involves interviews and testing new approaches to ensure patients get the right follow-up care.
Los Angeles, CaliforniaAges 21 years+ - NCT06560671Recruiting
App vs. paper for colonoscopy prep education
This study compares a new smartphone app to standard paper instructions for helping patients get their bowel ready for colonoscopy. It aims to see which method is easier to understand and leads to a better exam.
HsinchuAges 18 years+ - NCT06630962Recruiting
Financial help for newly diagnosed cancer patients
This study looks at whether getting help with financial issues (like insurance and costs) can reduce the money worries and problems that come with cancer treatment. It is for people newly diagnosed with breast, colorectal, or prostate cancer who haven't started treatment yet.
Ile-IfeAges 18 years+ - NCT06645808RecruitingEarly Phase 1
PET imaging study for various solid tumors
This study uses a special PET scan to see if a new imaging agent can help find and monitor certain solid tumors. It is for people with colon, rectal, sarcoma, breast, lung, head and neck, esophageal, stomach, pancreas, bladder cancers, or glioblastoma who have had standard treatment before surgery.
Groningen, Provincie GroningenAges 18 years+ - NCT06791512RecruitingPhase 3
Chemo Plus Targeted Therapy With or Without Immunotherapy for Colorectal Cancer
This trial compares a standard chemotherapy combination (mFOLFOX6) plus a targeted drug (bevacizumab) with or without an immunotherapy (PD-1 antibody) for locally advanced colorectal cancer. It aims to see if adding the immunotherapy improves outcomes for patients with a specific tumor type (pMMR/MSS).
Guangzhou, GuangdongAges 18–80 - NCT06815406Recruiting
Removing large colon polyps: one piece vs. multiple pieces
This trial compares two ways to remove large, flat polyps (granular type) from the colon or rectum: one that removes the polyp in one piece (endoscopic submucosal dissection) and one that removes it in pieces (endoscopic mucosal resection). The goal is to see which method has a lower chance of the polyp coming back.
BolognaAges 18 years+
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 894 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.