Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06769087Enrolling by invitation
Removing urinary catheter right after colorectal cancer surgery
This study compares taking out the urinary catheter immediately after colorectal cancer surgery versus leaving it in for one day. It aims to see which approach leads to fewer complications and faster recovery.
Seoul, SeoulAges 19–80 - NCT06752031Recruiting
Improving hospital-to-home transition after colorectal surgery
This study aims to improve the process of transitioning from hospital to home after colorectal surgery in older adults. It tests a new care coordination approach to help patients recover safely and avoid complications.
Salem, MassachusettsAges 65 years+ - NCT06753903Recruiting
Photon counting CT for liver metastasis from colorectal cancer
This trial tests a new type of CT scanner (photon counting CT) to see if it can better find liver spread from colorectal cancer. If you have colorectal cancer and need a liver check, this might help improve detection.
MilanAges 18–100 - NCT06750094RecruitingPhase 3
Study of amivantamab plus FOLFIRI in colorectal cancer
This trial tests adding amivantamab to standard FOLFIRI chemotherapy for people with certain types of colorectal cancer that have already been treated once. It aims to see if this combination works better than another common treatment (cetuximab or bevacizumab plus FOLFIRI).
Chandler, ArizonaAges 18 years+ - NCT06441565RecruitingPhase 2/Phase 3
Fruquintinib with or without liver-directed chemo for advanced colorectal cancer
This trial tests a drug called fruquintinib, given alone or with a chemotherapy infusion directly into your liver, for people whose colorectal cancer has spread to the liver and has stopped responding to standard treatments. It aims to find a new option for patients with limited cancer outside the liver.
Guangzhou, GuangdongAges 18–75 - NCT06745895Recruiting
Colorectal cancer and hepatitis C education and screening study
This study helps people who go to certain clinics get screened for colorectal cancer and hepatitis C. It provides information and support to those who haven't had all their recommended screenings yet.
Tampa, FloridaAges 45–75 - NCT06738173Recruiting
Gut bacteria test to screen for colorectal cancer
This trial tests a new tool that looks at gut bacteria to help find colorectal cancer earlier. It's for people who already had a positive result on a standard stool test (FIT) as part of a national screening program.
Rome, RMAges 50–74 - NCT06729736Enrolling by invitation
Faster recovery after colorectal cancer surgery
This trial is testing a program called ERAS (Enhanced Recovery After Surgery) to help patients recover faster after minimally invasive colorectal cancer surgery. It aims to improve your recovery and reduce hospital stay.
Seoul, SeoulAges 19 years+ - NCT06733038RecruitingPhase 3
Chemo plus Avastin with or without Tecentriq for advanced colorectal cancer
This trial tests whether adding the immunotherapy drug atezolizumab (Tecentriq) to standard chemotherapy (FOLFOXIRI) and bevacizumab (Avastin) is more effective as a first treatment for people with a specific type of metastatic colorectal cancer that has a high immune score and is mismatch repair proficient.
Brescia, BSAges 18–75 - NCT06728072RecruitingPhase 2
Adding antibiotics to first chemo for advanced colorectal cancer
This trial tests whether adding a short course of antibiotics to your standard first chemotherapy for stage 4 colorectal cancer can improve treatment. The antibiotics target certain gut bacteria that might affect how well the chemo works.
Richmond, VirginiaAges 18 years+ - NCT06722183RecruitingPhase 2
Futibatinib plus chemo-immunotherapy for advanced colorectal cancer
This trial tests a new combination of drugs (futibatinib plus chemo-immunotherapy) for people with advanced colorectal cancer who have not had prior treatment. It aims to see if this combination can shrink tumors or slow their growth.
AmbergAges 18 years+ - NCT06568679Recruiting
Improving detection and treatment of early-onset colorectal cancer
This study aims to find better ways to detect and treat colorectal cancer in younger adults (ages 18–49). It includes people with both early-stage and advanced cancer.
Amsterdam, North HollandAges 18–49 - NCT06714357RecruitingPhase 2
Valproic Acid to Boost Anti-EGFR in Colorectal Cancer
This trial tests whether adding valproic acid to standard anti-EGFR plus irinotecan can stop or reverse resistance in metastatic colorectal cancer. It is for patients who previously responded well to an anti-EGFR drug and then progressed.
Caserta, CEAges 18 years+ - NCT06714318Recruiting
Using blood samples to improve colorectal cancer screening
This study is looking at whether adding a blood test can make the current stool-based screening for colorectal cancer more accurate. It may help find cancers earlier or reduce the need for colonoscopy.
AabenraaAges 50–74 - NCT06698146Recruiting
Liver transplant for colorectal cancer that spread to the liver
This trial tests a special approach for colorectal cancer that has spread to the liver: first removing the liver tumor, then doing a partial liver transplant, and later removing more liver tissue. The goal is to see if this can help people who otherwise have limited options.
Chicago, IllinoisAges 18 years+ - NCT06685497Recruiting
Digital app for better recovery after colorectal cancer surgery
This study tests a digital app (the COLORECTUM+ system) to help improve recovery after colorectal cancer surgery. It is designed for patients treated at Renji Hospital in Shanghai.
ShanghaiAges 18 years+ - NCT06689293Recruiting
Stool test for follow-up after colorectal cancer treatment
This trial is testing whether a simple stool test (FIT) can replace some follow-up colonoscopies or CT scans for people who have been treated for colorectal cancer. If you are due for a routine check-up after your cancer surgery, you may be able to take this test at home instead of having a more invasive procedure.
NottinghamAges 18 years+ - NCT06682650Recruiting
Colorectal cancer screening tool for Spanish-speaking communities
This study tests if a new tool can help clinics in Spanish-speaking communities get more people screened for colorectal cancer. If you are an adult 45–75 who is due for screening and get care at a participating clinic, you may be eligible.
Aurora, ColoradoAges 45–75 - NCT06682793RecruitingPhase 1/Phase 2
Study of A2B395 therapy for solid tumors with EGFR and HLA loss
This trial tests a new cell therapy called A2B395 for cancers that have EGFR, a protein on the cell surface, and have lost a specific marker called HLA-A*02. The therapy uses specially engineered immune cells to target and kill these cancer cells. This may help patients with colorectal, lung, head and neck, breast, kidney, or other solid tumors that are no longer responding to standard treatments.
Gilbert, ArizonaAges 18 years+ - NCT06663319RecruitingPhase 1
Study of JNJ-89402638 for metastatic colorectal and gastric cancers
This trial tests a new drug, JNJ-89402638, alone or with other treatments for people with metastatic colorectal or gastric cancer that has progressed after standard therapies. It aims to find safe and effective doses and combinations.
Tucson, ArizonaAges 18 years+ - NCT06662786RecruitingPhase 3
Amivantamab plus chemo vs. standard chemo for left-sided colorectal cancer
This trial compares a new combination (amivantamab plus chemotherapy) with the standard treatment (cetuximab plus chemotherapy) as the first therapy for people with left-sided colorectal cancer that has spread. The goal is to see which approach works better when the tumor has no mutations in the KRAS, NRAS, or BRAF genes.
Gilbert, ArizonaAges 18 years+ - NCT06657924RecruitingPhase 2
TXA to Prevent Bleeding in Colorectal Surgery
This trial tests a medicine called tranexamic acid (TXA) given right before major colorectal surgery to see if it helps reduce bleeding. If it works, it could make surgery safer for people like you.
Cleveland, OhioAges 18–100 - NCT06434597RecruitingPhase 2
Study of SPH5030 for HER2-positive advanced colorectal or bile duct cancer
This study tests a new medication (SPH5030) for people with advanced colorectal or biliary tract cancer whose tumors have a specific marker called HER2. It may offer a treatment option if previous therapies have stopped working.
BeijingAges 18 years+ - NCT06634875RecruitingPhase 2
Test of isunakinra alone or with pembrolizumab for colorectal cancer
This trial tests a new drug combination (isunakinra plus pembrolizumab) for people with a specific type of colorectal cancer (MSS, RAS-mutated) that has a high tumor mutational burden. It may help if other treatments have stopped working.
Los Angeles, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,202 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.