Clinical trials
Craniotomy clinical trials
Below are recruiting craniotomy clinical trials, each written for real people, not researchers. We’re tracking 24 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03861299Recruiting
Awake brain surgery versus sleep surgery for glioblastoma
This study compares two ways of doing brain surgery for glioblastoma: doing parts of the operation while you are awake, versus doing it fully under general anesthesia (sleep). It aims to see which approach is safer and better for protecting brain functions like speech and movement while removing the tumor.
GhentAges 18–90 - NCT06792864Enrolling by invitationPhase 3
3D bone graft for skull repair after surgery
This trial tests a special 3D bone graft material to repair skull defects after brain surgery. It may help people who need a strong, custom-fit implant to protect their brain.
ValdiviaAges 18–70 - NCT06762184Recruiting
Pain scores in serious brain surgery patients after ICU care
This study looks back at patients who had brain surgery and were in the intensive care unit (ICU) for more than 24 hours. Researchers want to learn about their pain scores, which can help improve care for future patients.
Beijing, BeijingAges 18 years+ - NCT07118020Enrolling by invitation
Study of Tutopatch in skull surgery after craniotomy
This study is testing a patch called Tutopatch used during craniotomy, a surgery that opens part of the skull. The goal is to gather more information about how well it works after it is already approved for use.
SalzburgAges Any age - NCT05195034Recruiting
Dexmedetomidine to prevent confusion after awake brain surgery
This trial looks at whether a medication called dexmedetomidine can reduce “postoperative delirium,” a temporary period of confusion after awake brain surgery. If you have the type of surgery the study focuses on, this could help your recovery and mental clarity afterward.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05789394RecruitingPhase 1
Stem cell treatment for recurrent brain tumor surgery
This Phase 1 study tests an “allogenic” stem cell product made from donated fat tissue to treat recurrent glioblastoma or certain recurrent astrocytoma. It gives the treatment around the time of a repeat brain surgery, and focuses on safety while also studying why it might help.
Jacksonville, FloridaAges 18 years+ - NCT06810336RecruitingEarly Phase 1
Pain control after brain surgery: methadone vs remifentanil
This trial compares two medicines, methadone and remifentanil, to see which one works better for pain after brain surgery. It may help improve your recovery and comfort.
Charlottesville, VirginiaAges 18–65 - NCT06993922Recruiting
Scalp block with added sedative for brain surgery pain
This study tests adding a sedative (dexmedetomidine) to the usual numbing medicine (bupivacaine) for a scalp block before brain surgery. The goal is to see if this combination reduces pain after surgery better than the numbing medicine alone.
CairoAges 18–65 - NCT07209345Recruiting
Scalp pain relief after brain surgery
This trial tests whether numbing the scalp before brain surgery can reduce pain afterward. You would receive a painkiller injection in your scalp before your surgery begins.
BeijingAges 18–64 - NCT07093151Enrolling by invitation
Comparing blood pressure goals after brain tumor surgery
This study looks at two different blood pressure targets after surgery to remove a brain tumor. The goal is to see which target helps patients recover better and have fewer complications.
Nashville, TennesseeAges 18 years+ - NCT06988124Recruiting
Dexamethasone for nausea after brain surgery
This trial tests whether a steroid called dexamethasone palmitate can prevent nausea and vomiting after brain surgery. It is for adults having a planned craniotomy under general anesthesia.
BeijingAges 18–65 - NCT06780852Recruiting
Cranial flap fixation with bioresorbable bone adhesive study
This trial is testing a new, dissolvable bone glue to fix bone flaps back in place after skull surgery. It may help people who need a planned skull procedure (craniotomy) in the upper part of the head.
BristolAges 18–75 - NCT04229966Recruiting
Study of real-world treatment for acute epidural bleeding after injury
This observational study looks at how doctors treat an acute epidural hematoma in large head-injury surgeries as they would in routine care. It may help improve understanding of which real-world treatment choices lead to better outcomes.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06201429Recruiting
New device for draining fluid after brain surgery
This study tests a new device to remove extra fluid from the brain during surgery. It may be an option if you need a brain operation that uses a drain.
Buffalo, New YorkAges 22–65 - NCT07399093Recruiting
Ultrasound test before brain surgery anesthesia
This trial uses ultrasound to measure blood flow and fluid levels in the body before brain surgery. It aims to help doctors manage fluids better during and after anesthesia.
CairoAges 18–40 - NCT05851989Recruiting
Studying outcomes after burst brain blood vessel aneurysms
This study looks at what happens over time after a burst brain blood vessel aneurysm that caused bleeding around the brain. Your care team may use the study results to better predict outcomes and guide treatment for people like you.
AmsterdamAges 18 years+ - NCT06132685RecruitingPhase 2
Dexamethasone dosing after brain tumor surgery
This trial tests how to best use dexamethasone (a steroid) after brain tumor surgery to help recovery and reduce swelling. It looks at different dosing schedules for patients with common brain tumors.
Atlanta, GeorgiaAges 18 years+ - NCT06229483RecruitingPhase 3
Does tranexamic acid reduce bleeding during brain tumor surgery?
This study tests whether a medication called tranexamic acid (TXA) given during brain tumor surgery can reduce bleeding. If you are having a standard craniotomy for a tumor and don’t have certain health risks, you may be eligible.
Halifax, Nova ScotiaAges 18–80 - NCT06779396RecruitingPhase 4
Scalp injection to reduce pain after brain surgery in children
This trial tests if injecting a mix of two medicines (triamcinolone and ropivacaine) into the scalp before brain surgery can lower pain in children afterward. It compares this to standard care to see if it helps kids recover more comfortably.
Beijing, Beijing MunicipalityAges 2–12 - NCT06894433Recruiting
Surgery for large brain bleeds
This trial tests a type of keyhole surgery called neuroendoscopic surgery to remove large blood clots in the brain. It may help people who have had a serious brain bleed and need urgent surgery.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT07049094RecruitingPhase 4
Scalp nerve block for pain after brain surgery
This trial tests if a long-lasting numbing medicine (bupivacaine liposomes) injected into scalp nerves can reduce pain after brain surgery. It may help you need less pain medicine and feel better after your operation.
Hangzhou, ZhejiangAges 18 years+ - NCT07205263Recruiting
AI-guided minimally invasive surgery for brain bleeding
This trial tests a minimally invasive surgery guided by artificial intelligence to treat spontaneous brain bleeding. It aims to improve recovery by precisely removing the clot with less damage to healthy brain tissue.
Hangzhou, ZhejiangAges 18 years+ - NCT07411690Recruiting
Spinal fluid leak after brain tumor surgery
This trial checks for spinal fluid leaks after surgery to remove brain tumors. If you are having a planned first-time surgery for a tumor in the upper part of the brain, you may be eligible.
WarsawAges 18 years+ - NCT07034898Enrolling by invitationPhase 4
Dexmedetomidine vs Labetalol for Airway Stress in Brain Surgery
This trial compares two medicines (dexmedetomidine and labetalol) to see which one better controls stress on the airway during brain surgery in people with high blood pressure. The goal is to find a safer way to manage your heart rate and blood pressure while you are under anesthesia.
CairoAges 30–60
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Common questions
- Are there clinical trials for craniotomy?
- Yes. Clin2 currently lists 24 recruiting craniotomy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a craniotomy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a craniotomy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.