Clinical trials
Critically Ill clinical trials
Below are recruiting critically ill clinical trials, each written for real people, not researchers. We’re tracking 352 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06473844Recruiting
SGLT2 inhibitors for adults with sepsis
This trial tests whether a type of diabetes medicine (SGLT2 inhibitors) can help adults with sepsis, a life-threatening response to infection. If you have new-onset sepsis and can take oral medicine, you may be eligible.
Hong Kong, Hong KongAges 18 years+ - NCT06478160Recruiting
Closed blood-sampling system for ICU patients
This trial is testing a new way to draw blood from an arterial line that may reduce infection and blood loss. It is for adults in the ICU who need an arterial line for several days.
Madrid, MadridAges 18 years+ - NCT06481644Recruiting
Study of kids in Asian pediatric ICUs
This study looks at children admitted to pediatric intensive care units (ICUs) in Asia to understand their health patterns and outcomes. It may help improve care for future patients.
SingaporeAges Any age - NCT07694206Recruiting
Digital and blood tests for delirium in the ICU
This trial studies whether digital tools and blood tests can help detect delirium (sudden confusion) in ICU patients. If you or your loved one is in the ICU, this research could lead to better monitoring and care.
La Jolla, CaliforniaAges 65 years+ - NCT06446739Recruiting
Low-dose vs standard-dose kidney therapy for ICU patients
This study compares two different doses of continuous kidney replacement therapy (CRRT, a type of dialysis) for patients in the intensive care unit with acute kidney injury. It aims to find out if a lower dose is as safe and effective as the standard dose.
Rochester, MinnesotaAges 18 years+ - NCT07656259Recruiting
Comparing breathing support methods in the heart ICU
This study compares different ways to support breathing in patients who need a ventilator in the cardiac intensive care unit. It aims to find the best approach for people with certain heart conditions, like cardiogenic shock or heart failure.
Rochester, MinnesotaAges 18 years+ - NCT06486467Recruiting
AI-guided ultrasound to measure blood flow in ICU patients
This trial tests whether a simple ultrasound measurement of blood flow in your heart, guided by artificial intelligence, can be reliably done by minimally trained staff. It aims to help doctors decide when to give fluids to ICU patients who need them.
LimogesAges 18 years+ - NCT06490835Recruiting
Palliative care support for ICU families
This study tests a new way to bring high-quality palliative care (comfort and support for serious illness) to families of patients in the intensive care unit. If you are a family member of a patient with a severe brain injury or advanced organ failure, this study offers extra support and guidance during a difficult time.
Seoul, N/A (Not Applicable)Ages 19 years+ - NCT06501118Recruiting
Oxygen levels in ICU patients on breathing machines
This study tests whether giving a little more oxygen to ICU patients on breathing machines leads to better recovery. It compares usual oxygen levels to a more liberal target to see which is safer and more effective.
Aurora, ColoradoAges 18 years+ - NCT06505447Recruiting
Sleep study for kids in the PICU
This study looks at how sleep and body rhythms are affected when a child is in the pediatric intensive care unit (PICU). It may help doctors find ways to improve sleep for children who are in the hospital.
Buffalo, New YorkAges 3–6 - NCT06513130Recruiting
Checkup after ICU for adults 75 and older
This study looks at how well older adults (75+) do after leaving the intensive care unit. It will test a simple checkup done at discharge to see if it helps doctors plan better care.
StrasbourgAges 75 years+ - NCT06521086Recruiting
Better nutrition recovery for trauma patients
This study tests if a special nutrition plan helps older adults recover better after a traumatic injury. It aims to improve healing by providing extra nutrition through food and drinks.
Durham, North CarolinaAges 45 years+ - NCT06526533RecruitingPhase 3
Red blood cell transfusion thresholds for ECMO patients
This trial is testing whether a higher or lower threshold for red blood cell transfusions is better for people on ECMO (a heart-lung machine). It aims to find the safest way to manage transfusions during ECMO treatment.
Camperdown, New South WalesAges Any age - NCT06570187RecruitingPhase 4
Dexmedetomidine for kidney protection in sepsis
This trial tests if dexmedetomidine, a sedative, can help protect the kidneys of critically ill patients with sepsis who develop acute kidney injury (a sudden drop in kidney function). It is for adults in the ICU who need a breathing tube or mask within 48 hours of kidney injury.
CairoAges 18–90 - NCT06574672Recruiting
Palliative care in the medical ICU
This study tests whether adding palliative care (comfort and support care) to usual MICU treatment helps patients and families. It takes place in the medical intensive care unit.
St Louis, MissouriAges 18 years+ - NCT06578468Recruiting
Using exhaled oxygen to prevent low oxygen during emergency intubation
This trial tests a method to measure oxygen in the air you breathe out during emergency intubation. It aims to help doctors prevent low oxygen levels in patients at high risk, such as those with pneumonia, sepsis, or obesity.
Minneapolis, MinnesotaAges 18 years+ - NCT06588556Recruiting
Improving Care for Older Adults in the ICU
This study tests a program to improve communication and support for older adults in the ICU and their families. It may help families feel more supported during a serious illness.
Birmingham, AlabamaAges 18 years+ - NCT07643597Recruiting
Managing fluid removal in critically ill patients with acute kidney injury
This study looks at how to safely remove excess fluid from patients in the ICU who have sudden kidney failure and are on a special blood-filtering machine (CRRT). Researchers want to understand which patients have trouble tolerating fluid removal and how to prevent complications.
SalvadorAges 18 years+ - NCT07530146RecruitingPhase 3
Sedation Medications for Older ICU Patients on Breathing Machines
This study compares two sedation medications—propofol alone versus propofol combined with ketamine—in older patients in the ICU who are on breathing machines due to infection or lung problems. The goal is to find which combination is safer and works better for keeping patients calm and comfortable.
CairoAges 65 years+ - NCT06606119Recruiting
Brain, bone marrow, and gut study after major injury
This study is looking at how the brain, bone marrow, and gut interact after a severe injury. It may help doctors understand how to better treat trauma patients.
Gainesville, FloridaAges 18–100 - NCT06652126Recruiting
Immune status and ICU infections study
This study looks at how having a weakened immune system affects the risk of getting infections with hard-to-treat bacteria in the ICU. Depending on your immune status, you may be placed in a group that helps doctors understand who is most at risk.
LilleAges 18 years+ - NCT06665529Recruiting
Predicting 28-day survival in the ICU
This trial looks at how doctors and nurses predict survival for critically ill patients in the intensive care unit, compared to a standard medical score. It may help understand the accuracy of these predictions.
Kfar SabaAges 18–99 - NCT06667999RecruitingPhase 4
Intensive care platform trial for adult ICU patients
This major trial tests multiple treatments at once for adults admitted to the ICU. If you are an ICU patient, you may be able to join and receive one of several possible treatments aimed at improving recovery.
AabenraaAges 18 years+ - NCT06681649Recruiting
ICU follow-up care for survivors and their caregivers
This study tests a bundle of follow-up care for ICU survivors and their caregivers after leaving the hospital. It aims to improve recovery and support for both patients and their families.
Kingston, OntarioAges 18 years+
Hear when a new Critically Ill trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for critically ill?
- Yes. Clin2 currently lists 352 recruiting critically ill studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critically ill trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critically ill trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.