Clinical trials
Degenerative Disc Disease clinical trials
Below are recruiting degenerative disc disease clinical trials, each written for real people, not researchers. We’re tracking 72 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04775537Recruiting
OssiMend bone graft for lumbar spine fusion surgery
This trial studies whether OssiMend bone graft helps heal a lumbar spine fusion for people whose disc disease has not improved with non-surgical care. It may be an option if you need back surgery due to specific spine wear-and-tear changes.
Encinitas, CaliforniaAges 18 years+ - NCT06011551Recruiting
Gel injection for painful lumbar discs
This trial tests a gel (HYDRAFIL-D) injected into painful discs in your lower back to see if it relieves pain. It's for people whose back pain hasn't improved with other treatments.
Birmingham, AlabamaAges 22–85 - NCT05997121Recruiting
Testing a new spinal implant for degenerative disc disease
This trial studies a new spinal implant system (Hexanium TLIF) for people with degenerative disc disease. It aims to see if the implant is safe and works well to help with back pain and stability.
BrugesAges 18 years+ - NCT06000319Enrolling by invitation
NMP fibers for spine fusion surgery
This study tests a new material called NMP fibers used during spine fusion surgery to treat conditions like degenerative disc disease, spinal stenosis, or spondylolisthesis. The goal is to see how well it works for patients having fusion in the neck or lower back.
Jasper, AlabamaAges 18 years+ - NCT05691231Enrolling by invitation
Follow-up study for the NuVasive Simplify Disc implant
This study checks how safe and how well a specific artificial disc (the NuVasive Simplify Disc) works over the long term at two implant sizes/levels. It is for people who were already enrolled in an earlier disc study and are still willing to participate.
Charlotte, North CarolinaAges 18 years+ - NCT05701059Recruiting
Tests different artificial discs for neck nerve and spinal cord problems
This trial compares two types of artificial disc implants used for certain neck problems. It may help people who have tried non-surgical treatments but still have ongoing nerve symptoms or spinal cord issues from a damaged disc in the neck.
Los Angeles, CaliforniaAges 18–60 - NCT05296889Recruiting
Safety follow-up for Ennovate cervical device
This study checks how safely and effectively a cervical device (Ennovate® Cervical) works after it’s been used in routine care. It may help by monitoring real-world safety and performance over time.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT05029726RecruitingPhase 4
Numbing medicine during back surgery to reduce pain
This trial tests a regional anesthesia (numbing medicine given near nerves) during minimally invasive lumbar spine surgery. The goal is to see if it helps control pain around surgery and improves recovery comfort.
Chicago, IllinoisAges 18–80 - NCT04770571Enrolling by invitation
Study of posterior neck and upper-back spine fixation systems
This trial studies specific surgical hardware used to stabilize the back of the neck and upper back during spine surgery. It may help surgeons compare outcomes for people needing fixation for trauma, instability, failed prior fusion, tumors, or certain degenerative conditions.
Orange, CaliforniaAges 18 years+ - NCT04418830Enrolling by invitation
Study of a spine cage implant for degenerative back problems
This trial studies how well specific lumbar (lower back) implant “cages” help fuse vertebrae in people with degenerative disc disease, spinal slippage, narrowing, curvature, or forward-bending deformity. It may help by testing an approach to improve stability and reduce symptoms after surgery.
La Jolla, CaliforniaAges 18 years+ - NCT04042844RecruitingPhase 2
Single injection treatment for chronic low back disc pain
This Phase 2 study tests whether one injection of BRTX 100 can reduce pain and improve function in people with chronic, disc-related low back pain. It looks for whether the treatment is safe and works better than what you’ve already tried.
Birmingham, AlabamaAges 18 years+ - NCT06075979Recruiting
Microbes and spine health: a surgical study
This study looks at whether certain microbes (tiny living things) are linked to spine problems like herniated discs or narrow spinal canals. It involves people who need spine surgery, and the findings might help explain why some spines wear out faster.
Jinan, ShandongAges 18–85 - NCT07877766Enrolling by invitation
Microbiome study for patients having neck fusion surgery
This study looks at the bacteria in your body before and after neck surgery to see if they affect recovery. It may help improve care for future patients.
New York, New YorkAges 18–80 - NCT03810573Recruiting
Bone graft for spinal fusion surgery
This trial tests a new bone graft material to help bones in the lower spine fuse together after surgery. It may be an option for people with degenerative disc disease or a mild spinal slip.
Clayton, VictoriaAges 17–70 - NCT06029764Recruiting
Extended fusion for spinal disc vacuum signs
This trial tests a surgery that fuses one extra spinal disc to treat a 'vacuum sign' (air pockets in the disc) that hasn't caused symptoms yet. It aims to prevent future problems in people with lumbar disc disease who need fusion surgery.
Beijing, Beijing MunicipalityAges 18–60 - NCT07858643RecruitingPhase 1/Phase 2
A study of LDGraft for single-level lumbar fusion
This study tests a new graft material called LDGraft that may help fuse two vertebrae in your lower back after surgery. If you have degenerative disc disease in one lumbar level and haven't found relief from non-surgical treatments, this trial might be an option.
TbilisiAges 22–80 - NCT07834931Recruiting
Spine implant for low back pain from disc degeneration
This study tests an implant placed in the lower spine to treat back pain caused by disc degeneration. It aims to see if the implant helps reduce pain and improve function in people who have not improved with other treatments.
Madrid, MadridAges Any age - NCT07834749Recruiting
Fortilink-SC device study for neck and spinal stenosis
This study tests a new spinal device to see how well it works for people with neck pain and spinal stenosis. It may help reduce pain and improve function.
Madrid, MadridAges Any age - NCT07834736Recruiting
Titanium implant for lower back disc pain
This study tests a new titanium implant to help stabilize the lower spine in people with painful, worn-out discs. It aims to see if the implant works well and is safe in everyday practice.
Madrid, MadridAges Any age - NCT04601363Recruiting
Personalized spine registry for people with spinal hardware
This registry follows people who recently had spinal surgery where custom (patient-specific) spine hardware (like rods) was placed. It collects consent and health questionnaires to learn how these implants affect patients over time.
Aurora, ColoradoAges 10–85 - NCT07615491Recruiting
Safety and effectiveness study of spinal implants and bone materials
This study tracks how well spinal implants (Titania systems) and bone-filling materials (BONEGRAFT) work after surgery and whether patients experience any problems. Researchers will follow patients after cervical or lower spine surgery to confirm these devices are safe and effective in real-world use.
IzmirAges 18 years+ - NCT07552519Recruiting
Patient Outcomes in Spinal Disease Treatment
This study tracks how patients feel and function after receiving treatment for spinal disease (which may include procedures like spinal cord stimulation). Researchers want to understand what matters most to patients during their recovery.
Hasselt, LimburgAges 18 years+ - NCT06971835Enrolling by invitation
NanoParticle Matrix spine surgery registry
This study follows people who receive a special bone graft material called NanoParticle Matrix (NPM) during spine surgery. Researchers want to track outcomes over two years to see how well it works.
Baton Rouge, LouisianaAges 18 years+ - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65
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Common questions
- Are there clinical trials for degenerative disc disease?
- Yes. Clin2 currently lists 72 recruiting degenerative disc disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a degenerative disc disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a degenerative disc disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.