Clinical trials
Lumbar Degenerative Disease clinical trials
Below are recruiting lumbar degenerative disease clinical trials, each written for real people, not researchers. We’re tracking 55 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07254806RecruitingPhase 3
Cell therapy for low back pain from disc disease
This study tests if injecting a special cell therapy into a damaged spinal disc can reduce chronic low back pain. It is for people who have had low back pain for at least 6 months and haven't gotten enough relief from other treatments like physical therapy or pain medication.
Birmingham, AlabamaAges 18–75 - NCT06075966Enrolling by invitation
A new surgery for lumbar disc disease without fusion
This trial tests a surgical technique that treats a damaged disc in your lower back without permanently fusing the bones together. It may be an option if you have had at least 3 months of other treatments like physical therapy or medication and they have not helped enough.
Jinan, ShandongAges 18–85 - NCT06075979Recruiting
Microbes and spine health: a surgical study
This study looks at whether certain microbes (tiny living things) are linked to spine problems like herniated discs or narrow spinal canals. It involves people who need spine surgery, and the findings might help explain why some spines wear out faster.
Jinan, ShandongAges 18–85 - NCT06940453Recruiting
A new cage for spinal fusion surgery
This trial is testing a new device called the CONDUIT cage for a type of back surgery called anterior lumbar interbody fusion (ALIF). The surgery helps treat degenerative disc disease in the lower back by fusing two vertebrae together using a cage to support the spine. The study will see how well this cage works in patients who are already scheduled for this surgery.
Dublin, LeinsterAges 18 years+ - NCT07289737Recruiting
Comparing two spine surgeries for a slipped backbone
This study compares two types of spine surgery for a common condition where a lower back bone slips forward. It aims to see which surgery works better to relieve pain and improve function.
Yiwu, ZhejiangAges 50–90 - NCT07222787Recruiting
Testing a new spinal implant for lower back fusion
This trial tests a new spinal implant system (CORUS-LX) for fusing two lower back discs that are causing pain. It is meant for people with severe, long-lasting back or leg pain that hasn't improved with non-surgical treatments.
Scottsdale, ArizonaAges 18–80 - NCT07133724Recruiting
Digital health study for lumbar spine wear and tear
This study uses digital tools to measure how lumbar degeneration affects walking. It aims to find early signs of spine problems in people without current back pain.
TaipeiAges 50–80 - NCT07386548Recruiting
Biologic injection for low back disc problems
This study tests if an injection can help people with a herniated disc in the lower back who have not gotten better with other treatments and are already planning surgery. It aims to see if the injection can reduce symptoms and possibly avoid or improve surgery outcomes.
Manhattan, New YorkAges 18 years+ - NCT04467944Recruiting
Lumbar fusion outcomes with arthritis in nearby spine segments
This study looks at how well lumbar fusion surgery works long-term when the joint just above or below (adjacent segment) already shows wear-and-tear. It may help predict who benefits most and guide treatment planning.
Beijing, Beijing MunicipalityAges 18–80 - NCT04469387Recruiting
Reduce adjacent back pain after lumbar surgery
This trial looks at whether a limited decompression (a careful nerve-space “freeing” procedure) can help prevent future problems in the spinal level next to your planned surgery. It targets people with spinal canal narrowing next to the surgery level but who do not yet have symptoms there.
Beijing, Beijing MunicipalityAges 18–80 - NCT04631133Recruiting
Study of outcomes after surgery using the LISA implant
This study follows adults who get back surgery using the LISA implant to see how well they do afterward and how outcomes change over time. It focuses on people whose long-term, non-surgical care did not relieve low-back pain from specific age-related disc changes.
SilkeborgAges 18 years+ - NCT04775537Recruiting
OssiMend bone graft for lumbar spine fusion surgery
This trial studies whether OssiMend bone graft helps heal a lumbar spine fusion for people whose disc disease has not improved with non-surgical care. It may be an option if you need back surgery due to specific spine wear-and-tear changes.
Encinitas, CaliforniaAges 18 years+ - NCT05029726RecruitingPhase 4
Numbing medicine during back surgery to reduce pain
This trial tests a regional anesthesia (numbing medicine given near nerves) during minimally invasive lumbar spine surgery. The goal is to see if it helps control pain around surgery and improves recovery comfort.
Chicago, IllinoisAges 18–80 - NCT06320899Recruiting
Comparing different rods for lower back spine surgery
This study tests two types of rods (mid/high-flex vs low-flex) used during back surgery for people with degenerative spine problems in the lower back. The goal is to see which type helps reduce pain and improve movement better.
AarbergAges 18–99 - NCT06462729RecruitingPhase 1/Phase 2
Testing a new bone graft for lower back fusion surgery
This trial tests a new bone graft material called LDGraft for people who need a single-level lower back fusion (anterior lumbar interbody fusion). It aims to see if the new graft is as good as or better than current options for helping bones heal together.
Fort Wayne, IndianaAges 22–80 - NCT06778447Recruiting
Disc injection for chronic low back pain
This study tests whether injecting a special disc material (nucleus pulposus allograft) into the damaged discs of your lower back can safely reduce pain and improve function. It's for people with long-term, moderate to severe low back pain from disc disease that hasn't gotten better with other treatments.
Napa, CaliforniaAges 22–85 - NCT07017634RecruitingPhase 3
Novosis Putty for spine fusion in lumbar disc disease
This trial tests a new bone graft putty (Novosis Putty) used during a specific type of spine fusion surgery (TLIF) to treat a worn-out disc causing low back and leg pain. The goal is to see if it works as well as or better than current options.
Baton Rouge, LouisianaAges 21–80 - NCT07085247Recruiting
Role of bacteria in lower back disc disease
This trial looks at whether a specific bacteria, Cutibacterium acnes, is linked to disc problems in the lower back. If you're having surgery for a herniated disc, your tissue sample may help researchers understand the cause.
BrnoAges 18 years+ - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+ - NCT06000319Enrolling by invitation
NMP fibers for spine fusion surgery
This study tests a new material called NMP fibers used during spine fusion surgery to treat conditions like degenerative disc disease, spinal stenosis, or spondylolisthesis. The goal is to see how well it works for patients having fusion in the neck or lower back.
Jasper, AlabamaAges 18 years+ - NCT04418830Enrolling by invitation
Study of a spine cage implant for degenerative back problems
This trial studies how well specific lumbar (lower back) implant “cages” help fuse vertebrae in people with degenerative disc disease, spinal slippage, narrowing, curvature, or forward-bending deformity. It may help by testing an approach to improve stability and reduce symptoms after surgery.
La Jolla, CaliforniaAges 18 years+ - NCT05287867Recruiting
Study for painful degenerative disc disease treatment
This trial is testing a treatment approach for people with long-lasting, painful worn-out discs in the lower back (and sometimes leg pain). It looks for people who tried common non-surgical options without enough relief and who may be headed toward a lumbar procedure.
Broomfield, ColoradoAges 25–65 - NCT04042844RecruitingPhase 2
Single injection treatment for chronic low back disc pain
This Phase 2 study tests whether one injection of BRTX 100 can reduce pain and improve function in people with chronic, disc-related low back pain. It looks for whether the treatment is safe and works better than what you’ve already tried.
Birmingham, AlabamaAges 18 years+ - NCT06650046Recruiting
Topping-off technique for lower back arthritis
This trial tests a 'topping-off' surgical technique for people with arthritis and disc problems in the lower back. If you have tried 3 months of non-surgical treatments without success, this surgery may be an option to relieve pain and improve function.
Jinan, ShandongAges 18–85
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Common questions
- Are there clinical trials for lumbar degenerative disease?
- Yes. Clin2 currently lists 55 recruiting lumbar degenerative disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lumbar degenerative disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lumbar degenerative disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.