Clinical trials
Degenerative Disc Disease clinical trials
Below are recruiting degenerative disc disease clinical trials, each written for real people, not researchers. We’re tracking 72 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06686017Enrolling by invitation
New bone graft for lower back fusion surgery
This trial studies a new bone graft material called Virtuos for use in lower back spinal fusion surgery. It may help patients needing a one or two-level lumbar fusion by providing a safe and effective option for bone healing.
South Bend, IndianaAges 18 years+ - NCT06438471RecruitingPhase 1
Study of a new drug for nerve pain after spinal cord injury
This trial tests an experimental pill for people with spinal cord injury who have long-term nerve pain. It aims to see if the drug can reduce pain and be safe.
Augusta, GeorgiaAges 18 years+ - NCT06415123Enrolling by invitation
Study comparing new bone graft to standard for spinal fusion
This study tests a new bone graft material (MagnetOs Flex Matrix) compared to a standard bone graft for spinal fusion surgery. It may be an option if you have ongoing back or leg pain that hasn't improved with other treatments and you need a one-time fusion of up to 4 levels in your lower back.
Southfield, MichiganAges 18 years+ - NCT05812092Enrolling by invitation
Surgery for one or two levels of neck disc degeneration
This trial studies whether an operation to remove and decompress damaged neck discs (and fuse the area) helps people with painful nerve problems in the neck/arm. It’s meant for cases where non-surgery treatments haven’t worked and imaging shows the problem matches your symptoms.
Fort Worth, TexasAges 18 years+ - NCT05508360Recruiting
Testing an artificial spacer implant for one-level low back pain
This study tests whether inserting a small artificial implant into a single painful disc can reduce long-term low back pain and disability. It’s for people who tried non-surgical treatments for at least 6 months but still have significant symptoms from degenerative disc disease.
Medellín, AntioquiaAges 22 years+ - NCT05329129Recruiting
Spine surgery registry to track recovery with bone graft
This study follows people who are having spinal fusion surgery using an OssDsign bone graft. It collects health and scan information over time to better understand recovery and outcomes after surgery.
Fresno, CaliforniaAges 21 years+ - NCT05238740Recruiting
Compare fusion results after two spine surgeries with added biologics
This study compares two types of spine surgery (ALIF or XLIF) for one spinal level, and tests how well the bones fuse when a specific bone-forming product is used. It also looks at how patients feel and function after surgery.
BernAges 18–70 - NCT05037968Recruiting
Test bone graft materials for multi-level back fusion surgery
This trial compares two bone-graft materials to help bones heal after back fusion surgery using a rod/screw system. It may help people who have ongoing back or leg pain despite at least 3 months of non-surgical treatments.
Hartford, ConnecticutAges 18 years+ - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT04689854Enrolling by invitation
Cervical spine surgery implant study for neck disc problems
This trial studies specific neck (cervical) spine implants used during surgery for degenerative disc disease or neck instability, along with a particular kind of bone grafting and supporting hardware. It may help patients by testing whether these devices and the planned fusion approach work safely and effectively in real-world surgery.
Orange, CaliforniaAges 18 years+ - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04388332Recruiting
Neck surgery compares two bone graft materials
This study compares two materials used during neck surgery for degenerative disc disease: donor bone (structural allograft) versus a titanium cage (Tritanium C). It aims to see which option works better for healing the fused neck bones and improving symptoms.
Pittsburgh, PennsylvaniaAges 18–80 - NCT04204135Enrolling by invitation
Tracking hip flexor weakness after specific spine surgeries
This trial follows how hip flexor strength changes after two types of lower-back surgeries (ALIF or LLIF). It may help doctors better predict and prevent weakness in the hip and leg after surgery.
Chicago, IllinoisAges Up to 65 years - NCT03649490Enrolling by invitation
Testing new spinal implant materials for XLIF fusion
This study compares different advanced materials used in a specific spinal fusion surgery (XLIF). It aims to see which implant material helps the bone fuse well and safely over time.
Hartford, ConnecticutAges 18–80 - NCT07222787Recruiting
Testing a new spinal implant for lower back fusion
This trial tests a new spinal implant system (CORUS-LX) for fusing two lower back discs that are causing pain. It is meant for people with severe, long-lasting back or leg pain that hasn't improved with non-surgical treatments.
Scottsdale, ArizonaAges 18–80 - NCT05066711Enrolling by invitation
Study of a neck surgery implant for adults
This trial looks at using a specific implant system during planned front-of-the-neck surgery (C2 to C7) for common neck problems like disc degeneration, injury, or spinal narrowing. It may help doctors compare outcomes with this particular hardware and surgical approach.
Naperville, IllinoisAges 18 years+ - NCT04641039Recruiting
Study of scar differences after lumbar disc replacement
This study compares how postoperative scars look and behave after certain lumbar disc replacement surgery. It may help doctors choose approaches that reduce excessive scar-related problems after surgery.
Valencia, ValenciaAges 18–50 - NCT06320899Recruiting
Comparing different rods for lower back spine surgery
This study tests two types of rods (mid/high-flex vs low-flex) used during back surgery for people with degenerative spine problems in the lower back. The goal is to see which type helps reduce pain and improve movement better.
AarbergAges 18–99 - NCT07837427Recruiting
Different water pressures during minimally invasive back surgery
This study compares two different water pressures used during a minimally invasive back surgery to see if one causes fewer complications and gives the surgeon a clearer view. It aims to help improve recovery and surgical outcomes for people with lower back problems.
Kunming, YunnanAges 18–75 - NCT07788872Recruiting
Talking tool to help prepare for back surgery
This study tests a dialogue support tool that helps you and your surgeon talk through your back surgery and recovery. It aims to make your meetings clearer and more helpful.
Oslo, NordbyhagenAges 18 years+ - NCT05299762Recruiting
INFUSE bone graft for lower back fusion: patient follow-up study
This study tracks patients who receive INFUSE bone graft during a specific type of lower back fusion surgery. It helps confirm how the device performs in real-world care and monitors safety and outcomes after surgery.
SeoulAges 18 years+ - NCT07489001Recruiting
Comparing opioid-free to standard anesthesia for back surgery
This study compares two types of anesthesia for lower back surgery: one that uses opioids and one that does not. The goal is to see which approach controls pain better with fewer side effects.
Istanbul, MaltepeAges 18–75 - NCT07587775Enrolling by invitationPhase 2
Osteoporosis Medication Effects on Spine Bone Quality
This study tests how a bone-strengthening medication called Abaloparatide affects the quality of bones in your lower spine. Researchers will use imaging scans to see if the medication helps improve bone strength in people with osteoporosis who also have spine wear-and-tear.
Buffalo, New YorkAges 50 years+ - NCT06601634Recruiting
Neck pain improvement after cervical spine surgery
This study looks at what factors help predict better neck pain after a specific type of neck surgery called ACDF. If you have a degenerative neck condition and are scheduled for this surgery, the results could help doctors understand what leads to the best pain relief.
Krakow, Lesser Poland VoivodeshipAges 18–65
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Common questions
- Are there clinical trials for degenerative disc disease?
- Yes. Clin2 currently lists 72 recruiting degenerative disc disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a degenerative disc disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a degenerative disc disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.