Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT06057337Recruiting
Families with pride for Hispanic LGBTQ+ teens
This study helps Hispanic LGBTQ+ teens and their families build stronger bonds and pride. It includes family activities and conversations to support your identity and well-being.
Coral Gables, FloridaAges 13–19 - NCT06075771RecruitingPhase 4
Testing a Parkinson's drug for depression-related loss of interest
This trial tests whether a medication used for Parkinson's disease (carbidopa-levodopa) can help people with major depression who have lost interest or pleasure in things. It is for adults who have not been helped enough by other treatments and have signs of inflammation.
Atlanta, GeorgiaAges 25–55 - NCT06072677Recruiting
Mood and testosterone in young teens
This study looks at how mood changes during puberty in young people aged 11 to 14. It tests whether using a mindfulness app (Healthy Minds) can help teens who have been through stress or feel down.
Chapel Hill, North CarolinaAges 11–14 - NCT06038929Recruiting
Vagus nerve stimulation and stomach function study
This study looks at how vagus nerve stimulation (VNS) affects how your stomach works, like emptying and stretching. It may help researchers understand the digestive side effects of VNS in people who already have a VNS device for epilepsy or depression.
Minneapolis, MinnesotaAges 18 years+ - NCT06038721Recruiting
Unified Protocol for kids with emotional concerns
This trial tests a program called Unified Protocol for children ages 7–17 who have emotional difficulties like anxiety, depression, trauma, or obsessive-compulsive symptoms. It aims to help kids and their parents learn skills to manage these feelings together.
Coral Gables, FloridaAges 7–17 - NCT06034821Enrolling by invitationPhase 4
ECT vs. ketamine for suicidal depression in adults
This trial compares two treatments—ECT (electroconvulsive therapy, which uses electrical stimulation) and ketamine (a medicine given as a shot)—to see which works better for quickly reducing suicidal depression. It is for adults who are in a severe depressive episode with active suicidal thoughts.
San Francisco, CaliforniaAges 18–90 - NCT06032377Recruiting
Online therapy for sleep and brain health in older adults
This study tests an online talk therapy program (CBT) to help older adults with both sleep troubles and mild memory or thinking concerns. It's done from home, and aims to improve sleep and brain health.
Ottawa, OntarioAges 60–99 - NCT06046586Recruiting
Online therapy for cancer survivors with anxiety or depression
This trial tests an online therapy program for cancer survivors who feel anxious, depressed, or worried about cancer coming back. It's a text-based program you can do from home.
StockholmAges 18 years+ - NCT06004414Recruiting
SilverCloud mental health app study for high school students
This study tests a mental health app called SilverCloud in high school students who are feeling anxious or depressed. It aims to see if the app can help improve their mood and wellbeing.
New Brunswick, New JerseyAges 13–22 - NCT05992831Recruiting
Transcranial magnetic stimulation for mild cognitive impairment
This trial tests whether transcranial magnetic stimulation (a noninvasive brain stimulation technique) can help people with mild cognitive impairment (MCI). You and a close contact, like a spouse or friend, will both take part in the study over several sessions.
Charleston, South CarolinaAges 60–85 - NCT05996900Recruiting
Brain stimulation study for adults with epilepsy
This study uses advanced brain monitoring and noninvasive magnetic stimulation to understand how repetitive brain stimulation works in people with epilepsy who are already scheduled for hospital monitoring. It may help develop better treatments for seizures.
Stanford, CaliforniaAges 18–65 - NCT05991713Recruiting
GPS and brain study for healthy volunteers
This study uses a smartphone GPS app and brain scans (fMRI) to understand how daily emotions and movement patterns are connected. It may help researchers learn more about how people's environments affect their feelings.
Coral Gables, FloridaAges 18–50 - NCT05989451Recruiting
Talk therapy for depression and anxiety
This trial tests a type of talk therapy called dialectical behavior therapy (DBT) adapted to help people with emotional disorders like depression or anxiety. It aims to improve emotional regulation and reduce symptoms.
TaipeiAges 18–65 - NCT05967390Enrolling by invitation
Personalized brain-mapping test using a scalp-to-brain scan
This trial looks at whether a personalized brain “map” using imaging and scalp measurements can be measured and evaluated in people who can safely attend the testing. It may help researchers better understand how brain structure relates to performance, using scan-based measurements and related procedures.
Hong KongAges 60–95 - NCT05962879Recruiting
Program for teens with early psychosis-like experiences
This trial tests a new mental health program for teenagers who are having at least one psychosis-like experience and may be at risk for serious mental illness. It may help by offering structured support for both teens and their parents.
Boston, MassachusettsAges 14–19 - NCT05965310Recruiting
Virtual psychology support for ACL repair recovery
This study tests a virtual (online) psychological program to help people recover after ACL ligament surgery. It focuses on first-time ACL repairs and aims to improve how patients cope during recovery.
Detroit, MichiganAges 13 years+ - NCT05800535Recruiting
Screening for muscle loss and thinking changes after cancer
This study looks at how common muscle weakness (sarcopenia) and thinking or memory changes (often called “chemobrain”) are in people after cancer treatment. It may help teams understand what support could be most helpful after chemotherapy.
Pierre-BéniteAges 18–74 - NCT05927974Recruiting
Brain mapping during surgery for hard-to-control epilepsy
This trial studies how the brain’s control networks work during a surgery-related procedure for people with epilepsy that hasn’t improved with usual treatments. If you qualify, you may do specific tasks while the team maps and measures brain activity to better understand and guide care.
Birmingham, AlabamaAges 18 years+ - NCT05934474Recruiting
Study collects blood to learn about inflammation in mental illness
This study collects biological samples to better understand how “inflammation” in the body may relate to certain mental health conditions. Your results may help doctors learn more about causes and future treatments, even if the study does not give a new drug.
NantesAges 18 years+ - NCT05632497Recruiting
Testing gut microbiome changes in adults with anorexia
This study looks at how changing the gut bacteria (microbiome) may affect people hospitalized for anorexia nervosa. You may be eligible if you’re an adult with a very low BMI and meet the study’s timing and health requirements.
VillejuifAges 18 years+ - NCT05897021Recruiting
Writing exercises to ease stress for sexual minority veterans
This study tests whether guided “expressive writing” helps reduce distress linked to sexuality-based stress. It targets veterans who have meaningful anxiety or depression symptoms and ongoing stress related to their sexual identity.
Boston, MassachusettsAges 18 years+ - NCT05883540RecruitingPhase 2
LSD therapy in palliative care for comfort and well-being
This Phase 2 study tests how LSD may affect comfort and quality of life for people with advanced or end-stage life-limiting illness. It also checks whether the medicine is safe and can be given in a controlled way in palliative care settings.
BaselAges 22 years+ - NCT05897619Recruiting
CBT skills app for pregnancy and postpartum stress and coping
This study tests whether a new phone app that teaches “cognitive behavioral therapy” (CBT) skills is helpful and easy to use for people who are pregnant or recently gave birth. It also checks safety and whether participants feel the app is acceptable to use over time.
New York, New YorkAges 18 years+
Hear when a new Depressed trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,419 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.