Clinical trials · Los Angeles, CA
Depression clinical trials in Los Angeles
We’re tracking 71 recruiting depression studies with a site in or near Los Angeles — including Early Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Los Angeles
- NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Los Angeles, CaliforniaAges 18–70 - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Los Angeles, CaliforniaAges 18–85 - NCT03887715Recruiting
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Los Angeles, CaliforniaAges 18 years+ - NCT06572683Enrolling by invitation
Novel TMS for hard-to-treat depression
This trial tests a new type of transcranial magnetic stimulation (TMS) for people with severe depression that hasn't improved with multiple medications or therapy. It uses a different frequency pattern to target brain circuits.
Los Angeles, CaliforniaAges 21–75 - NCT07577947Recruiting
Digital tracking to help treat pregnancy and postpartum depression
This study tests whether wearing an Apple Watch and using a smartphone app can help doctors better understand and treat depression during pregnancy and after birth. You'll receive depression treatment through the study while the app and watch track your daily patterns.
Los Angeles, CaliforniaAges 18 years+ - NCT07281352RecruitingPhase 1/Phase 2
Psilocybin therapy for depression
This study tests if psilocybin (a psychedelic) combined with cognitive behavioral therapy (CBT) can help people with major depression. You would receive the psilocybin in a supervised setting and have talk therapy before and after.
Los Angeles, CaliforniaAges 21–60 - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT05598034Recruiting
Brain stimulation with tDCS for moderate depression
This study tests whether a noninvasive brain stimulation called tDCS can improve depression symptoms. It also uses MRI scans, aiming to understand how brain changes may relate to symptom improvement.
Los Angeles, CaliforniaAges 20–55 - NCT05591937Recruiting
Online therapy and prevention support for eligible East LA students
This project offers online mental health prevention and therapy programs and short assessments for eligible students. It may help you access support in a convenient way if you meet the study’s student, coverage, and technology needs.
Los Angeles, CaliforniaAges 18–40 - NCT06856057Recruiting
Support for caregivers and kids after injury
This study helps parents and young children cope with stress after a hospital stay for an injury. It tests a program to improve mental health for both caregivers and kids.
Los Angeles, CaliforniaAges 18 years+ - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Glendale, CaliforniaAges 18–65 - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Glendale, CaliforniaAges 18–74 - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Glendale, CaliforniaAges 18–65 - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Glendale, CaliforniaAges 18–65 - NCT06911112RecruitingPhase 3
A new pill for depression when current treatment isn't working well enough
This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.
Glendale, CaliforniaAges 18 years+ - NCT07161700Enrolling by invitationPhase 2
Long-term safety study of SPT-300 for major depression
This study is for people who finished the earlier BUOY-1 study of SPT-300 and want to continue treatment. It tests the long-term safety and tolerability of SPT-300 for major depressive disorder, with or without anxious distress.
Glendale, CaliforniaAges 18–66 - NCT07065240RecruitingPhase 2
Study of SPT-300 for major depression with or without anxiety
This trial tests an experimental oral medication, SPT-300, for people with major depressive disorder, even if they also have mild anxiety. The goal is to see if it helps improve mood safely.
Glendale, CaliforniaAges 18–65 - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Glendale, CaliforniaAges 18–74 - NCT06569303Recruiting
Filipino family health study for parents of children 8–12
This study offers a free parenting program for Filipino families with children ages 8–12 to help strengthen family bonds and manage challenges together. It is designed to understand what works best for your community.
Pasadena, CaliforniaAges 8 years+ - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Culver City, CaliforniaAges 10–17 - NCT05850689RecruitingPhase 3
Lumateperone add-on for major depression that didn’t improve
This study tests whether adding lumateperone to an antidepressant helps adults with major depressive disorder (MDD) who haven’t improved enough after trying at least two different antidepressants. It may help reduce depressive symptoms more than antidepressants alone.
Pico Rivera, CaliforniaAges 18–65 - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Pico Rivera, CaliforniaAges 18 years+ - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT06898879Recruiting
Working together to improve mental health care for veterans
This study is for veterans getting mental health support through VA programs. It tests a way to improve teamwork between veterans and their care teams to make the care better.
West Los Angeles, CaliforniaAges 18 years+
Hear when a new Depression trial opens near Los Angeles, CA
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Depression trials in other cities
Where these studies are running near Los Angeles
Institutions with a site for the recruiting depression studies listed above.
- Behavioral Research Specialists, LLC · 4 studies
- ATP Clinical Research · 2 studies
- Neurocrine Clinical Site · 2 studies
- NRC Research Institute · 2 studies
- Seaport Investigator Site · 2 studies
- Syrentis Clinical Research · 2 studies
- Accellacare - Long Beach /ID# 279482
- Advanced Research Center /ID# 227073
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in California.
Common questions
- Are there depression clinical trials near Los Angeles?
- Yes. We're currently tracking 71 recruiting depression studies with a site near Los Angeles, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Los Angeles?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Los Angeles to take part?
- Not necessarily. These studies have a site near Los Angeles, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Los Angeles regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.