Clinical trials · San Francisco, CA
Depression clinical trials in San Francisco
We’re tracking 62 recruiting depression studies with a site in or near San Francisco — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near San Francisco
- NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Lafayette, CaliforniaAges 18–70 - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Lafayette, CaliforniaAges 18–65 - NCT07621237RecruitingPhase 2
TNX-102 SL for Major Depressive Disorder
This study tests whether a new medication called TNX-102 SL can reduce depression symptoms better than a placebo (inactive pill). You'll take the medication daily and have regular check-ins to see how you're doing.
Walnut Creek, CaliforniaAges 18 years+ - NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Walnut Creek, CaliforniaAges 18–64 - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Walnut Creek, CaliforniaAges 18–74 - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Walnut Creek, CaliforniaAges 18–65 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Walnut Creek, CaliforniaAges 18–65 - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Walnut Creek, CaliforniaAges 18–65 - NCT07822321RecruitingPhase 3
Brexanolone for severe postpartum depression
This trial tests an investigational medicine to help mothers with severe depression that started late in pregnancy or shortly after childbirth. It aims to improve mood and overall well-being.
Walnut Creek, CaliforniaAges 15–45 - NCT07484217RecruitingPhase 3
Testing solriamfetol for depression with daytime sleepiness
This study tests if the drug solriamfetol can help people with major depression who also feel very tired during the day. It aims to improve both mood and daytime sleepiness.
Walnut Creek, CaliforniaAges 18–65 - NCT04441034RecruitingPhase 4
Compare two medicines for long-term pain in real life
This trial compares two types of medicines—anti-convulsants and anti-depressants—for people with persistent pain lasting more than 3 months. It aims to find out which option works better in everyday care and for which patients.
Redwood City, CaliforniaAges 18 years+ - NCT06373718Recruiting
How sleep affects emotions in insomnia with low mood
This study explores how improving sleep might help regulate emotions in people who have both insomnia and mild depressive symptoms. You could help researchers understand the link between sleep and mood.
Palo Alto, CaliforniaAges 18–65 - NCT07022405RecruitingPhase 2
Medication study for depression with brain scans
This study tests whether a targeted medication can improve mood and brain function in adults with major depression. If you qualify, you'll receive a study drug and have fMRI brain scans to see how your brain responds.
Palo Alto, CaliforniaAges 18–65 - NCT04356274Enrolling by invitation
Improving access to addiction and mental health care at VA clinics
This study tests an approach to help VA clinics reach more Veterans with proven treatments for addiction and mental health conditions. It focuses on clinic-level processes (not individual medications) to increase how widely evidence-based care is delivered.
Palo Alto, CaliforniaAges 18 years+ - NCT06408246RecruitingPhase 2
Cognitive training and medication for depression
This study tests whether a combination of cognitive training (brain exercises) and a medication (guanfacine or sertraline) can improve thinking skills in people with depression. It involves MRI scans and computer tasks to understand how your brain responds.
Palo Alto, CaliforniaAges 18–60 - NCT07279311Enrolling by invitation
Virtual reality for depression during high-risk pregnancy
This study tests if virtual reality (VR) exercises can help reduce depression symptoms in pregnant people who must stay in the hospital for at least 3 weeks due to complications. If you are feeling down and are able to use VR, this treatment might offer a new way to feel better.
Palo Alto, CaliforniaAges 18 years+ - NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55 - NCT05379673Recruiting
Breathing changes with extra oxygen after surgery
This study looks at whether giving extra oxygen during recovery from general anesthesia changes how you breathe after surgery. You may be offered different oxygen levels around the time you wake up to see what helps your breathing most comfortably.
Stanford, CaliforniaAges 18–70 - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Stanford, CaliforniaAges 18–85 - NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Stanford, CaliforniaAges 18 years+ - NCT05996900Recruiting
Brain stimulation study for adults with epilepsy
This study uses advanced brain monitoring and noninvasive magnetic stimulation to understand how repetitive brain stimulation works in people with epilepsy who are already scheduled for hospital monitoring. It may help develop better treatments for seizures.
Stanford, CaliforniaAges 18–65 - NCT06824415Recruiting
Sleep TMS for depression
This trial tests whether a type of brain stimulation called TMS (transcranial magnetic stimulation), given during sleep, can improve depression. It's for adults who have not gotten enough relief from antidepressant medication.
Stanford, CaliforniaAges 18–65 - NCT04041479RecruitingPhase 3
Brain-scan guided rTMS for treatment-resistant depression
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
Stanford, CaliforniaAges 22–65 - NCT07188623Recruiting
Virtual reality therapy for older adults with depression
This study tests if a virtual reality program can help older adults with depression become more active and feel better. You would use a VR headset at home to practice activities that improve your mood.
Stanford, CaliforniaAges 65 years+
Hear when a new Depression trial opens near San Francisco, CA
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Depression trials in other cities
Where these studies are running near San Francisco
Institutions with a site for the recruiting depression studies listed above.
- Stanford University · 7 studies
- Clinical Research Site · 2 studies
- VA Palo Alto Health Care System · 2 studies
- Autobahn Site #119
- Autobahn Site #126
- Lipocine Investigational Site
- Lucile Packard Children's Hospital Stanford
- Neurocrine Clinical Site
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in California.
Common questions
- Are there depression clinical trials near San Francisco?
- Yes. We're currently tracking 62 recruiting depression studies with a site near San Francisco, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near San Francisco?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in San Francisco to take part?
- Not necessarily. These studies have a site near San Francisco, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near San Francisco regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.