Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Chino, CaliforniaAges 18 years+ - NCT07753473Recruiting
Brain stimulation for young adults with depressive symptoms
This study uses a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to see if it can improve how the brain and heart work together in people aged 18 to 30 who have mild depressive symptoms. The goal is to understand if this treatment could help with mood regulation.
Xi'an, ShaanxiAges 18–30 - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
Little Rock, ArkansasAges 18–74 - NCT07048600Recruiting
Brief trial of ACT-i for adults with chronic insomnia
This trial tests a psychological treatment called ACT-i for people with chronic insomnia (trouble sleeping for a long time). It aims to see if this online therapy can help improve sleep without drugs.
Cluj-NapocaAges 18–59 - NCT06238700Recruiting
Studying allopregnanolone for depression in midlife women
This trial tests whether allopregnanolone, a natural brain chemical, can help depression in women going through menopause. It compares the effects against a placebo to see if it improves mood symptoms.
Boston, MassachusettsAges 40–60 - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Birmingham, AlabamaAges 18 years+ - NCT05400382Recruiting
Mindfulness for depression and pain after cesarean delivery
This study tests whether a mindfulness program can help new mothers manage pain and depression after a planned cesarean delivery. You might be eligible if you are a woman of color or non-Hispanic White with a history of depression and are scheduled for a planned C-section.
Champaign, IllinoisAges 18–45 - NCT07412756RecruitingPhase 3
Brenipatide for major depressive disorder
This trial tests a new medication, Brenipatide, to see if it helps people with major depression who are already on a stable treatment. You would need to inject the study drug yourself and complete questionnaires.
Moorpark, CaliforniaAges 18–75 - NCT07607613Recruiting
Support for LGBTQ+ Parents with Depression Risk
This study offers group support sessions for LGBTQ+ parents who are pregnant or recently had a baby and are experiencing mild depression or worry about postpartum depression. The goal is to help prevent depression from getting worse and improve emotional well-being during this important life transition.
Chicago, IllinoisAges 18 years+ - NCT06891326Recruiting
Testing tACS for depression relief
This study tests if a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can safely treat depression. It uses mild electrical pulses on the scalp to help improve mood.
ShanghaiAges 18–65 - NCT06824532Recruiting
Veterans' views on ketamine therapy for depression and end-of-life
This study surveys older veterans to understand their perceptions of ketamine-assisted psychotherapy as a treatment for depression and end-of-life distress. Your responses may help improve care for veterans facing similar challenges.
Albany, New YorkAges 65 years+ - NCT06659315Recruiting
Preventing HIV transmission from mom to baby for depressed mothers in Malawi
This study tests a program to help pregnant women with HIV who also have depression, and their partners, reduce the risk of passing HIV to their babies. The program includes support for mental health and HIV care.
ZombaAges 18 years+ - NCT06623981Recruiting
Treating maternal depression in an urban asthma clinic
This study tests whether treating depression in Black mothers of children with asthma can improve both the mother's mood and the child's asthma. It offers support for mothers who are feeling down and may help their child's asthma get better.
Washington D.C., District of ColumbiaAges Any age - NCT06562153Recruiting
fMRI-guided TMS for depression
This trial tests whether combining fMRI brain scans with TMS (a non-invasive brain stimulation) can help treat depression more effectively. It is for adults with major depressive disorder who can safely undergo MRI.
Charleston, South CarolinaAges 18–65 - NCT06361095RecruitingEarly Phase 1
Brain training for depression: attention bias modification trial
This trial tests a computer-based brain training program designed to change how you pay attention to emotional information. It may help reduce depression symptoms by training your brain to focus less on negative cues.
Austin, TexasAges 18–70 - NCT06203899Recruiting
Depression and suicide prevention for teens in special schools
This study tests a program to prevent depression and suicide in teens at special schools. It helps if you've had some symptoms but aren't already getting treatment.
Boekel, Noordoost BrabantAges 12–18 - NCT06174285Recruiting
Psychedelic VR therapy for depression
This trial tests a new approach that combines virtual reality (VR) with a psychedelic-like experience to help people with depression. The therapy is designed to be used safely in a clinic and aims to improve mood and well-being.
Tallinn, HarjuAges 18–65 - NCT06145984Recruiting
Positive Thinking Techniques to Prevent Depression Relapse
This study tests whether positive thinking exercises help people who have recovered from depression stay well and avoid relapse. Researchers will compare people with a history of depression to those who've never had depression to understand how these techniques work.
Groningen, Provincie GroningenAges 18–60 - NCT06217198Recruiting
Computerized depression program for veterans
This trial tests a computer-based program to help veterans with mild to moderate depression. It aims to see if the program can improve mood and is accessible online.
Waco, TexasAges 18 years+ - NCT05976347RecruitingPhase 4
Treatment for depression after certain bone fractures
This trial tries to find and treat depression in people who have recently had surgery for an arm, leg, or pelvis fracture. It may help by screening for depression soon after surgery and offering a new depression treatment approach if you qualify.
Winston-Salem, North CarolinaAges 18 years+ - NCT05973461Recruiting
Exercise and virtual reality study for depression
This study looks at whether doing regular exercise and using virtual reality can help with depression symptoms, compared to not doing them. You may be included even if you do not currently have depression symptoms, as long as you meet the safety and participation requirements.
Arlington, TexasAges 18–65 - NCT05921201Recruiting
RRE program to prevent depression in Chinese American teens
This trial tests an education and skills program (Relax, Reflect, and Empower, or RRE) designed to help prevent depression in Chinese American teens. It may help by teaching coping strategies before symptoms become more serious.
Boston, MassachusettsAges 14–18 - NCT05732311Recruiting
Theta burst brain stimulation to help prevent depression relapse
This study tests whether intermittent theta burst stimulation (a type of brain stimulation using a magnetic device) can help keep depression from coming back after it has improved. It focuses on people whose depression has responded to an earlier iTBS treatment and who are able to safely receive TMS.
RegensburgAges 18–70 - NCT05599126RecruitingPhase 4
Mianserin plus SSRIs for depression with sleep trouble
This study tests whether adding mianserin to an SSRI (a common antidepressant) can improve depression in people whose main problem also includes sleep trouble. It may help by targeting both mood symptoms and difficulty sleeping.
ShanghaiAges 18–60
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.