Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04041479RecruitingPhase 3
Brain-scan guided rTMS for treatment-resistant depression
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
Stanford, CaliforniaAges 22–65 - NCT04014829Recruiting
Study of pain processing after planned hysterectomy
This trial looks at how the nervous system and fear of pain may affect pain after a planned hysterectomy. If you qualify, you may be asked about pain levels and pain sensitivity to better understand who may have more pain recovery challenges.
SingaporeAges 21–80 - NCT03065335RecruitingPhase 1
Ketamine plus brain imaging to study response in depression
This early-stage study tests how ketamine given once and then repeatedly may change brain signals and related biomarkers in people with major depression. If you’re eligible, the team will use brain imaging and assessments to see who responds and why.
Bethesda, MarylandAges 18–65 - NCT06423430Recruiting
Deep brain stimulation for treatment-resistant depression (TRANSCEND)
This trial tests a new brain stimulation treatment (deep brain stimulation, or DBS) for people with hard-to-treat depression. It aims to see if targeting a specific brain area can help when other treatments have failed.
Birmingham, AlabamaAges 22–70 - NCT07876908Recruiting
Magnetic brain therapy for older adults with hard-to-treat depression
This trial tests a new intensive magnetic brain treatment (SAINT) for older adults whose depression has not improved with standard treatments. It aims to see if this treatment can also help with memory concerns, which are common in this group.
Costa Mesa, CaliforniaAges 65 years+ - NCT06284889Recruiting
Behavioral activation for depression in older adults
This study tests a program called Behavioral Activation, a type of talk therapy that helps you engage in positive activities to improve mood. If you are 65 or older and have mild to moderate depression, you may be able to join this telephone-based treatment.
Uppsala, UpplandAges 65 years+ - NCT02568878RecruitingPhase 3
Creatine to help depression and anxiety in meth users
This trial studies whether creatine can reduce depression and anxiety symptoms in people who currently use methamphetamine and also have depression and anxiety. It may help by improving mood and anxiety scores over the course of the study.
Missoula, MontanaAges 18–59 - NCT04685148RecruitingPhase 1/Phase 2
Study of mental health treatment during pregnancy
This trial studies a treatment aimed at improving maternal mental health during pregnancy. It focuses on people who have had depression around pregnancy before, and checks whether the approach is safe and helpful for them.
CopenhagenAges 18–45 - NCT05607654Recruiting
Brain stimulation for depression that hasn’t improved with usual treatment
This study tests how a specific kind of brain stimulation (repetitive transcranial magnetic stimulation) works for people with depression that has not responded to standard treatments. If you qualify, it may help doctors understand the mechanism and improve options for treatment-resistant depression.
Hangzhou, ZhejiangAges 18–45 - NCT05798143Recruiting
Testing brain-signal biomarkers in treatment-resistant depression
This trial studies signs in the brain (biomarkers) during an accelerated form of nerve stimulation to treat depression that hasn’t improved with usual antidepressants. It may help researchers learn who benefits and how to better personalize treatment.
ChietiAges 18–65 - NCT05766475Recruiting
In-person vs virtual postpartum depression prevention groups
This study compares two ways of delivering a group program to help prevent postpartum depression—either in person or online. If you’re pregnant and speak English or Spanish, you may be able to join the program and help researchers learn which format works best.
Denver, ColoradoAges 18 years+ - NCT05583747Recruiting
Brain stimulation therapy with guidance for treatment-resistant depression
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
Toronto, OntarioAges 18–65 - NCT05772897Recruiting
Parenting group for mothers with postpartum depression
This study offers a structured parenting skills group to help mothers’ mood after having a baby. It also includes some mothers without current depression symptoms for comparison, to better understand what helps.
Denver, ColoradoAges 18–50 - NCT06187454Recruiting
Brain stimulation for depression
This trial tests if a gentle brain stimulation called tDCS can help people with depression who haven't gotten better from antidepressants. It uses a small current on the scalp to try to improve mood.
TaipeiAges 60 years+ - NCT05011864Recruiting
Tele-therapy for depression and fall risk in homebound seniors
This study tests a combined phone/online counseling program to help treat depression and reduce fall risk in homebound older adults. It may help you feel better emotionally and become safer at home.
Austin, TexasAges 50–100 - NCT06767566RecruitingPhase 1
Ketamine for depression and pain after cesarean delivery
This study tests whether ketamine, a medicine given during cesarean delivery, can help prevent or reduce postpartum depression and pain. It aims to find the best dose for new mothers.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT03348761Recruiting
Brain stimulation for depression after antidepressants didn’t help
This study tests a non-invasive brain stimulation treatment (repetitive transcranial magnetic stimulation, or rTMS) in people with major depression who did not respond to antidepressant medicines. It may help some participants improve depression symptoms over time.
Hong KongAges 18–64 - NCT06278532Recruiting
Validating psychosis assessment tools in Lithuanian
This trial tests whether three psychiatric questionnaires work well for people with schizophrenia or related disorders. If you are between 18 and 65 and have one of these diagnoses, joining may help improve care for others like you.
KaunasAges 18–65 - NCT06266715Recruiting
Testing ATP for depression relief
This trial tests if a natural compound called ATP can help improve moderate to severe depression symptoms. If you haven't taken antidepressants recently and have never tried escitalopram, you may be eligible.
Guangzhou, GuangdongAges 18–65 - NCT05466851Recruiting
Study testing anxiety and depression biology and therapy markers
This study looks at “biopsychosocial markers” (biological, psychological, and social signs) in people with major depression and/or anxiety. It aims to understand what changes with treatment and how those changes connect to symptoms like anxiety and depression.
New York, New YorkAges 18–65 - NCT06054321Recruiting
Depression medication study for adults 19 to 65
This study tests a new way of choosing antidepressants for people with major depression. It's designed for adults aged 19–65 who have moderate to severe depression and are either starting a new antidepressant or have been off psychiatric meds for at least a month.
GwangjuAges 19–65 - NCT07843927RecruitingPhase 3
Adding DHEA hormone to antidepressants for difficult depression
This study tests whether adding a natural hormone called DHEA to your regular antidepressant can help improve depression symptoms. DHEA is a supplement that may boost the effectiveness of standard antidepressants for people with hard-to-treat depression.
Berlin, State of BerlinAges 18–75 - NCT07845604RecruitingPhase 2
Testing an anti-inflammatory drug with Lexapro for depression
This study tests whether an anti-inflammatory medication (adalimumab, also known as Humira) can help treat depression when added to Lexapro. It may help people whose depression is linked to higher levels of inflammation in the body.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07834684Recruiting
Singula health survey for routine primary care visits
This study tests a new survey during a regular doctor's visit to see if it helps improve care. If you join, you'll answer questions on your own device.
Brentwood, New YorkAges 18 years+
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.