Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06273982Enrolling by invitation
Telehealth for anxiety and depression in youth
This study tests whether a behavioral telehealth program can help teens and children with anxiety or depression. It is designed for patients in community health centers and includes support from a parent or guardian.
Portland, OregonAges 8–16 - NCT06002100Enrolling by invitation
Predicting depression treatment response with brain imaging
This study uses a special headband (TD-fNIRS) that measures brain activity to see if it can predict how well different depression treatments work. You would be starting a new treatment for depression (like ketamine, SPRAVATO, TMS, or antidepressants) and wear the headband before and during treatment.
Costa Mesa, CaliforniaAges 18–75 - NCT06663891Recruiting
MRI study of anergic depression in older adults
This study uses MRI brain scans to look for differences between people whose anergic depression started before age 60 and those whose depression began later in life (after 60). It aims to help understand the root causes of this specific type of depression in older adults.
Strasbourg, Grand EstAges 60–90 - NCT05507138RecruitingPhase 2
Digital therapy for depression and thinking problems after stroke
This Phase 2 trial tests a smartphone/tablet-based program to improve post-stroke depression and executive thinking skills (like planning and attention). It may help if you have ongoing depressive symptoms and thinking/executive difficulties at least 6 months after your first stroke.
New York, New YorkAges 50–79 - NCT05081596Recruiting
Primary care program for mood and thinking in early Alzheimer’s
This trial tests a psychosocial (talk/behavior/support) program delivered through primary care to improve thinking and depression symptoms in older adults with mild cognitive problems and early Alzheimer’s. It may help if you have early memory/thinking changes plus mild depressive symptoms and you can work with a caregiver or study partner.
White Plains, New YorkAges 60 years+ - NCT04982757Enrolling by invitation
Accelerated TMS to treat depression or OCD
This trial tests an “accelerated” form of transcranial magnetic stimulation (TMS) to reduce symptoms of depression or obsessive-compulsive disorder (OCD). You may be considered if standard treatments didn’t help (or you couldn’t tolerate them), and if it’s safe for you to receive TMS.
New York, New YorkAges 18–75 - NCT07574060RecruitingPhase 2/Phase 3
Allopurinol as an Add-On Treatment for Depression
This trial tests whether allopurinol, a medication typically used for gout, might help reduce depression symptoms when added to standard depression treatment. Researchers believe it may work by reducing inflammation in the brain that contributes to depression.
TantaAges 18–60 - NCT06636058Recruiting
Digital treatment for weight and mood in adults 50+
This study tests a digital program that helps with weight loss and depression at the same time. It is designed for Black, Hispanic, and other adults over 50 who carry extra weight and feel down.
Chicago, IllinoisAges 50–74 - NCT07121894Recruiting
Ketogenic diet for bipolar depression
This study tests whether a strict low-carbohydrate, high-fat (ketogenic) diet can improve symptoms of depression in people with bipolar disorder. Participants will receive dietary guidance and support to help them follow the diet for several weeks.
Rochester, MinnesotaAges 18–50 - NCT07768098Enrolling by invitation
Long-term follow-up study on late-life depression
This study is a follow-up of a previous study on depression in older adults. It aims to understand how depression develops and changes over time, which could help improve care in the future.
Leuven, FlandersAges 65 years+ - NCT07766161Recruiting
Light therapy for postpartum depression
This trial tests whether timed light therapy can improve postpartum depression symptoms. It focuses on new mothers within six months of giving birth who have elevated depression scores.
Ann Arbor, MichiganAges 18 years+ - NCT07226232RecruitingPhase 3
Psilocybin for veterans with treatment-resistant depression
This study tests whether psilocybin (a psychedelic substance) can help veterans with depression that hasn't improved with standard treatments.
Birmingham, AlabamaAges 18–75 - NCT05763537Recruiting
Study exploring how doulas support pregnancy mood changes
This study looks at how having a doula affects support and wellbeing for people experiencing pregnancy-related mood and anxiety changes. It may help you and others learn what kind of doula support is most helpful during pregnancy.
Missoula, MontanaAges 18 years+ - NCT06781697RecruitingPhase 3
Ketamine and virtual reality for treatment-resistant depression
This trial tests if adding virtual reality to ketamine treatments can help people with depression that hasn't improved with other treatments. You'll receive IV ketamine as prescribed by your doctor and also use a virtual reality headset during sessions.
Toronto, OntarioAges 18 years+ - NCT06103760RecruitingPhase 4
Esketamine for hard-to-treat depression
This study tests whether esketamine, a nasal spray for depression, can help adults whose depression has not improved with at least two other antidepressants. Participants continue their current treatment while receiving esketamine.
St Leonards, New South WalesAges 18–65 - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Phoenix, ArizonaAges 18–75 - NCT07462637Recruiting
Light therapy for depression in unipolar and bipolar disorder
This study tests how well light therapy works for moderate to severe depression in people with or without bipolar disorder. It includes a possible MRI brain scan to understand how light affects the brain. You must not have certain eye conditions or high suicide risk.
ParisAges 18–65 - NCT07120880RecruitingPhase 3
Light therapy timing for depression with insomnia
This trial tests whether giving light therapy at a specific time of day can improve both depression and sleep problems. It is for adults with major depression and insomnia who are not currently on antidepressants.
ParisAges 18–65 - NCT05142384Recruiting
Online therapy program for mothers with depression symptoms
This study tests an internet-based cognitive behavioral therapy (an online skills-based talk therapy) to help mothers with depression symptoms. It’s offered through Head Start, where participating moms and their children connect with the program.
Springfield, OregonAges 2 years+ - NCT05725239Recruiting
Testing vibration or magnetic stimulation for depression
This study tests whether taVNS, TMS, or both can improve depression symptoms. It may help people whose depression has not improved enough with usual treatments like antidepressant pills or talking therapy.
Charleston, South CarolinaAges 18–75 - NCT07757997Recruiting
Recovery and work after stress treatment
This study checks how people who completed a hospital program for stress-related issues are doing over time, focusing on their health and ability to work. It aims to understand the long-term effects of the treatment.
SüsAges 18–80 - NCT04556890Recruiting
Brain stimulation for treatment-resistant depression and chronic pain
This study tests a non-invasive brain stimulation treatment, called transcranial magnetic stimulation (TMS), to see if it can help people who have both major depression that hasn't improved with medication and chronic pain from fibromyalgia or chronic fatigue syndrome. It aims to reduce both depression and pain symptoms.
Los Angeles, CaliforniaAges 18–75 - NCT04870255Recruiting
Brain stimulation for depression in borderline personality disorder
This study tests a type of brain stimulation called rTMS to see if it can help improve mood in people who have both depression and borderline personality disorder. It may offer a new treatment option for those who haven't tried TMS before.
Stanford, CaliforniaAges 18–80 - NCT06911112RecruitingPhase 3
A new pill for depression when current treatment isn't working well enough
This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.
Huntsville, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.