Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06807801Recruiting
Baby swimming for postpartum depression and bonding
This study looks at whether taking your baby for swimming sessions can help with feelings of depression and strengthen the bond between you and your baby after childbirth.
UppsalaAges 18 years+ - NCT06753123Recruiting
Wellness program for hospital workers with depression
This study tests a program to help hospital workers with depression feel better and be more active. It includes support via text messages and aims to improve both your mood and your ability to work.
San Diego, CaliforniaAges 18 years+ - NCT07185438Recruiting
MRI-guided brain stimulation for teenage depression
This study tests whether a type of brain stimulation called rTMS, guided by an MRI scan, can safely help ease depression symptoms in teenagers. You would continue your regular medication during the study.
ChongqingAges 12–18 - NCT04245748RecruitingPhase 4
Finding the best order of treatments for anxious depression
This study tests which treatment sequence works best for people with anxiety conditions (generalized, social, separation) and/or panic, who also have significant depression/anxiety symptoms. It may help you find a more effective step-by-step plan and compare treatment orders.
Cincinnati, OhioAges 18–50 - NCT07143838Recruiting
Enhancing deep sleep to help depression
This study tests a gentle brain stimulation method (called transcranial electrical stimulation) during sleep to see if it can improve deep sleep and help with depression symptoms. It is for adults with moderate depression who also have some memory or thinking complaints.
Winston-Salem, North CarolinaAges 40–80 - NCT07500714Recruiting
Digital therapy for depression using AI
This study uses a smartphone app and artificial intelligence to deliver a special type of talk therapy for people with moderate to severe depression. It aims to provide personalized care without needing to change your current treatment.
Taichung, TaichungAges 18–75 - NCT07250893Recruiting
Resolving early life stress in depression: a psychotherapy study
This trial tests if a specific type of psychotherapy can help people with moderate-to-severe depression who experienced stress or adversity in childhood (before age 18). Researchers want to see how the treatment works in the brain and whether it improves depression symptoms.
Hamilton, OntarioAges 18–65 - NCT07050355Recruiting
Brain stimulation and exercise for depression after stroke
This study tests whether combining brain stimulation with aerobic exercise can help treat depression and improve walking in people who have had a stroke at least a year ago. If you have ongoing depressive symptoms and some leg weakness from your stroke, this treatment may help you feel better and walk more easily.
Durham, North CarolinaAges 21 years+ - NCT05097586Recruiting
At-home brain stimulation trial for depression during pregnancy
This trial tests whether doing at-home, noninvasive brain stimulation (tDCS) can reduce depression symptoms during pregnancy. It may help people who are in a depressive episode but prefer not to take antidepressant medication right now.
Toronto, OntarioAges 18 years+ - NCT07188623Recruiting
Virtual reality therapy for older adults with depression
This study tests if a virtual reality program can help older adults with depression become more active and feel better. You would use a VR headset at home to practice activities that improve your mood.
Stanford, CaliforniaAges 65 years+ - NCT06820723RecruitingPhase 2
Testing a single dose of CYB003 for depression and anxiety
This trial tests a single dose of an investigational drug (CYB003) in people with depression and anxiety who haven't gotten enough help from their current antidepressant. You would take a psilocybin-like medication and be monitored for how it affects your mood and anxiety.
Columbus, OhioAges 21–65 - NCT07651436Recruiting
Depression screening in patients on kidney dialysis
This study tests whether nurses can effectively screen for depression in patients receiving regular kidney dialysis treatment. The goal is to find the best way to identify depression early so patients can get help.
AnnecyAges 18 years+ - NCT07703722RecruitingPhase 3
Psilocybin and therapy for depression with trauma
This trial tests psilocybin (a compound from certain mushrooms) combined with a structured therapy to see if it helps people with depression linked to trauma. It focuses on how the treatment affects the connection between the gut and brain.
Islamabad, CapitalAges 18–60 - NCT04041479RecruitingPhase 3
Brain-scan guided rTMS for treatment-resistant depression
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
Stanford, CaliforniaAges 22–65 - NCT04123314RecruitingEarly Phase 1
Psilocybin study for depression in mild memory or early Alzheimer’s
This early-phase study tests whether psilocybin (a psychedelic substance) can help with depression in people who have mild memory problems or early Alzheimer’s. The trial also closely monitors safety, thinking changes, mood, and blood pressure before and after dosing.
Baltimore, MarylandAges 18–85 - NCT04159662Recruiting
Brain scans to study thinking in schizophrenia and depression
This study uses brain imaging to better understand how thinking works in people with schizophrenia or major depression. Your results may help researchers learn what brain patterns match different thinking and symptoms.
Ottawa, OntarioAges 18–60 - NCT04303325RecruitingPhase 4
Esketamine after breast surgery for depression and gut changes
This trial studies whether esketamine given around the time of breast cancer surgery can improve depression and change gut bacteria. It also monitors your sleep/deep anesthesia level (with a simple monitoring number).
Shenyang, LiaoningAges 18–65 - NCT07562191RecruitingPhase 2
Inhaled DMT for major depression
This trial tests if inhaling DMT can help treat moderate to severe major depression. You may qualify if your depression has lasted at least two weeks and you have not changed medications recently.
Fortaleza, CearáAges 18 years+ - NCT07226011Recruiting
Fast High-Dose Brain Stimulation for Depression
This study tests a stronger, faster type of brain stimulation (called tDCS) to see if it can help treat depression. It may be a good fit if you have major depression and haven't used other brain stimulation in the past 6 months.
Charleston, South CarolinaAges 18–70 - NCT04996433Recruiting
Compare two talk therapy programs for treatment-resistant depression
This study compares two psychotherapy programs to help people who have ongoing, difficult-to-treat depression while in inpatient care. If you qualify, you’ll receive one of the therapy programs and be followed to see which approach helps depression symptoms more.
Berlin, State of BerlinAges 18–75 - NCT05028738Recruiting
Test a brain stimulation program for depression and anxiety
This trial studies whether a patient-friendly, scheduled brain stimulation treatment can help reduce symptoms of depression and anxiety. It also checks whether the treatment plan is practical and safe to use in real outpatient settings.
Vancouver, British ColumbiaAges 18 years+ - NCT05194098Recruiting
EEG and brain stimulation study for depression reward symptoms
This study uses non-invasive brain stimulation (like TMS) and EEG brain recordings to measure how the brain’s “reward” system works in people with major depression. It may help researchers understand which stimulation approaches best affect depression-related reward processing.
San Francisco, CaliforniaAges 18–65 - NCT05456607Recruiting
Digital therapy for insomnia and depression in veterans
This study tests an online form of cognitive behavioral therapy (a structured talk-therapy style program you use digitally) to help people who have both trouble sleeping and depression. It may be helpful if you’re a U.S. military veteran and your symptoms are in the study’s range.
Rochester, New YorkAges 18 years+ - NCT05553353Recruiting
Repeated brain stimulation for depression after spinal cord injury
This study tests a non-drug treatment called repeated transcranial magnetic stimulation (rTMS) to reduce depression symptoms in people with depression after a spinal cord injury. You might be eligible if you have ongoing major depression and can safely receive magnetic pulses to the head.
Charleston, South CarolinaAges 18–60
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.