Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05570812RecruitingPhase 2
Pregnenolone to improve depressed mood in people with HIV
This Phase 2 trial tests a brain-acting steroid called pregnenolone to help reduce depressed mood. It studies whether it can improve mood in adults with HIV who are already on HIV treatment and still have depression symptoms.
Boston, MassachusettsAges 18–85 - NCT05596344Recruiting
Long-term check-in for anxiety and depression in cancer patients
This study will follow people with cancer over time to learn how anxiety and depression change. It may help doctors understand what support patients need and when.
Zhengzhou, HenanAges Any age - NCT05616559Recruiting
Precision-guided treatment for single-episode depression
This study tests a more personalized approach to treating depression in people who have had one episode. It uses questionnaires and brain scans (for some participants) to help decide which treatment approach may work best.
CopenhagenAges 18–65 - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05680220Recruiting
40 Hz light therapy for adults with depression
This trial studies whether daily 40 Hz light stimulation can reduce symptoms of major depression. You’d use a light device for about an hour each day for 6 weeks, while researchers track changes in depression severity.
Copenhagen, DenmarkAges 18–75 - NCT05800509Recruiting
Program for gestational diabetes and low mood in pregnancy
This study offers an intervention program to help people who are diagnosed with gestational diabetes and may also experience depression during pregnancy. It may help improve health during pregnancy and support mood and well-being with smartphone-based participation.
TaipeiAges 20 years+ - NCT05833087Recruiting
Schema therapy for long-lasting, hard-to-treat depression
This study tests whether schema therapy can help people with chronic depression that hasn’t improved enough with standard antidepressant treatments. You’d be in a psychiatric clinic and be assessed for severity and diagnosis, then receive the therapy being studied.
Ballerup MunicipalityAges 18–65 - NCT05855421Recruiting
Ear acupuncture sessions for moderate depression during COVID
This trial tests whether auricular (ear) acupuncture can safely improve symptoms of moderate depression during the COVID period. You may be able to join if you’re an adult with moderate depression and can attend the study sessions.
Palhoça, Santa CatarinaAges 18–50 - NCT05892744RecruitingPhase 4
Testing brain scans to help choose depression treatment
This trial studies how brain signals measured by MRI and EEG may help doctors choose the best treatment for depression. It focuses on people with early-onset, long-lasting or recurring major depression, and tests whether these “brain biomarkers” track with treatment choice and response.
Austin, TexasAges 18–65 - NCT05913960Recruiting
Theta-burst brain stimulation for major depression
This study tests whether an “accelerated intermittent theta-burst” brain stimulation treatment can improve major depressive disorder by affecting brain signaling pathways. You may be a candidate if you have moderate-to-severe depression and can safely undergo brain MRI.
Hangzhou, ZhejiangAges 12–45 - NCT05925322Recruiting
Social reward therapy for depression-related suicidal thoughts
This study looks at whether “social reward” psychotherapy can change brain activity and reduce suicidal thoughts in adults ages 50–80 who also have major depression. You may be offered psychotherapy along with brain scans to see how your brain responds over time.
New York, New YorkAges 50–80 - NCT05950698Recruiting
Study of obesity and bariatric surgery with mental and social factors
This study looks at how personal mental health and life circumstances relate to outcomes after bariatric (weight-loss) surgery. It may help the team understand what supports improve recovery and health after surgery.
Rio de Janeiro, Rio de Janeiro, BrazilAges 18–60 - NCT05958940Recruiting
Bright light therapy study for depression
This trial studies whether daily bright light therapy can reduce depressive symptoms. It’s for adults with depression (including some with bipolar depression), and you would fill out questionnaires and be screened for safety.
EindhovenAges 18–65 - NCT05973851RecruitingPhase 3
Six-week medicine boost for depression after first treatment failure
This study tests a more intensive antidepressant medicine approach for people whose first tried treatment didn’t work well enough. It compares the intensified treatment with usual care, aiming to improve depression symptoms and daily functioning.
InnsbruckAges 18–65 - NCT06049433Recruiting
Mental health support for new and expecting mothers
This study tests a program to help pregnant women and new mothers who may be at risk for depression after childbirth. The program offers extra support and resources to improve your mental health and well-being.
Salt Lake City, UtahAges 18 years+ - NCT06072898RecruitingPhase 2
Psilocybin brain imaging trial for depression
This study tests whether a single dose of psilocybin (a psychedelic compound) can help treat depression by looking at brain changes on MRI. It is designed for people with moderate-to-severe depression who have not responded well to other treatments.
Toronto, OntarioAges 18–64 - NCT06086366Recruiting
Brain scan study for depression after COVID-19
This study uses brain scans to understand depression that starts soon after COVID-19. Researchers want to see if there are changes in brain chemistry related to depression, and you may help find new treatment targets.
Toronto, OntarioAges 18–75 - NCT06092411Recruiting
CBT and light therapy for depressed youth who are night owls
This trial tests if combining cognitive behavioral therapy (CBT) with bright light therapy (BLT) helps Chinese teenagers and young adults who have depression and a natural tendency to stay up late. The goal is to improve mood and sleep patterns.
Hong KongAges 12–20 - NCT06163625Recruiting
Brain activity and memory in treatment-resistant depression
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Toronto, OntarioAges 18–65 - NCT07696871RecruitingPhase 1/Phase 2
Cannabidiol oil for treatment-resistant depression
This trial tests if cannabidiol (CBD) oil can help people with major depression that has not improved with standard antidepressants. You will take CBD oil or a placebo while continuing your current antidepressant treatment to see if it improves your symptoms.
Tubarão, Santa CatarinaAges 18–69 - NCT06456307Recruiting
Stepped care for mood and anxiety during pregnancy
This study tests a step-by-step approach to help pregnant women who are feeling anxious or down. If you are at least 28 weeks pregnant and feeling stressed, worried, or sad, the study will offer you support and check on how you are doing.
NairobiAges 14 years+ - NCT06469476Recruiting
Screening for postpartum depression after birth
This study looks at whether a special check-up within 8 weeks after birth (called the 'postnatal interview') helps find signs of postpartum depression early. It involves mothers who had their baby at the Troyes hospital and agrees to answer questions about their mood and wellbeing.
Troyes, Grand EstAges 18 years+ - NCT06480500RecruitingPhase 2
Online therapy and IV ketamine for severe depression with suicide risk
This study tests whether adding an online therapy (i-CBT) to intravenous (IV) ketamine is better than IV ketamine alone for people with treatment-resistant depression who are also thinking about suicide. You'll receive either ketamine or a comparison drug (midazolam), plus the online therapy, in a hospital setting.
Toronto, OntarioAges 21–65 - NCT06528938Recruiting
Accelerated vs. standard TMS for teen depression
This study tests whether a faster, brain-guided form of TMS (called iTBS) can help treat depression in teenagers better than standard TMS. You may qualify if you're 16–19, have tried an antidepressant that didn't work well, and have no medical reasons to avoid TMS or MRI.
Ottawa, OntarioAges 16–19
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.