Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06922409Recruiting
Light therapy for stroke recovery in rehabilitation
This trial tests whether exposure to naturalistic light can help reduce fatigue and depression after a stroke. It is designed for patients in a rehabilitation unit who are able to communicate and cooperate with simple physical exams.
Glostrup Municipality, Capital RegionAges 18 years+ - NCT06923423Recruiting
Cognitive processing therapy for drug use and trauma in prison
This study tests if a type of therapy called cognitive processing therapy (CPT) can help people in prison who have both a drug use problem and trauma-related stress. If you qualify, you would receive CPT and be compared to those getting usual care.
Little Rock, ArkansasAges 18 years+ - NCT06927076Recruiting
DMT with propofol for depression
This study tests whether a combination of DMT (a psychedelic) and propofol (a sedative) can help treat depression. You will receive both medicines in a hospital setting, and the team will monitor your response.
BaselAges 21 years+ - NCT06928480Recruiting
Unified Protocol for Emotional Health in Long COVID
This study tests a program to help people with Long COVID manage emotional difficulties like depression or anxiety. It combines different therapy approaches into one treatment, which you can receive online from home.
Zaragoza, ZaragozaAges 18 years+ - NCT06932783Recruiting
Electrical stimulation for pain and depression in cirrhosis
This study tests a gentle electrical stimulation device (like a TENS unit) to see if it can help with both pain and depression in people with cirrhosis. It is a non-drug treatment that you can use at home.
Ann Arbor, MichiganAges 18 years+ - NCT06938373Recruiting
A test for breast cancer patients with possible depression
This study tests a new detection method for depression in people with breast cancer. It uses samples like blood, stool, and saliva to find a link between breast cancer and depression.
Changsha, HunanAges 18–80 - NCT06941298Recruiting
Cannabis and depression study for teens and young adults
This study looks at how cannabis affects the brain and mood in teens and young adults. It compares people who use cannabis, people with depression who don't use cannabis, and healthy volunteers to understand links between cannabis use and mental health.
Miami, FloridaAges 14–20 - NCT06943105Recruiting
Nonviolent communication training for parents with depression or anxiety
This trial tests whether learning nonviolent communication skills can help parents with mild to severe depression or anxiety feel better and improve their relationships with their children. You may be able to join if you're a Hong Kong resident with a child in primary school and you speak Cantonese.
Hong KongAges 24–59 - NCT06948903Recruiting
Fibromyalgia, brain sensitivity and thinking
This study looks at how the brain's pain sensitivity (central sensitization) relates to memory and thinking problems in people with fibromyalgia. Participating could help doctors understand and treat these symptoms better.
Istanbul, UskudarAges 18–65 - NCT06951893Recruiting
Predicting quality of life after weight-loss surgery
This study looks at whether certain traits before weight-loss surgery can predict how a person's quality of life will change afterward. It aims to find patterns that could help doctors and patients make better decisions about treatment.
Chambéry, SavoieAges 18 years+ - NCT06962527Recruiting
Study on how the brain handles uncertainty
This study uses brain imaging to understand how people react to uncertain situations. It may help develop better ways to treat anxiety and related conditions.
Chicago, IllinoisAges 25–60 - NCT06975280Recruiting
PTSD therapy for unaccompanied refugee teens in Greece
This study tests a talking therapy (Trauma-Focused Cognitive Behavioral Therapy) to help unaccompanied refugee minors aged 15-18 who have PTSD or stress symptoms from trauma. It aims to see if the therapy reduces distress and helps them feel better.
AthensAges 15–18 - NCT06978166Recruiting
Digital therapy for chronic pain and mood
This study tests a smartphone app that gives you personalized tips and exercises to help manage chronic pain along with depression or anxiety. It is designed for adults ages 45 and older and aims to see if these digital check-ins can improve how you feel day to day.
St Louis, MissouriAges 45 years+ - NCT06978257Recruiting
Digital happiness skills study for anxiety and low mood
This study tests a smartphone-based program designed to boost positive feelings and reduce worry or low mood. It may help if you have mild to moderate anxiety or depression but are not severely affected or in crisis.
SingaporeAges 21–64 - NCT06979440Recruiting
Berberine for diabetes with depression
This trial tests if berberine, a natural compound, can improve both blood sugar and mood in people who have type 2 diabetes and major depression. It aims to understand how berberine works at a molecular level.
Nantong, JiangsuAges 18–65 - NCT06981598Recruiting
Preventing mental health issues with unit-based support
This trial studies how having behavioral health technicians (mental health support people) work directly in military units can help prevent psychological problems. It is for service members who are currently seeing one of these technicians, or for the technicians themselves who are embedded in a unit.
New York, New YorkAges 18 years+ - NCT06987799Recruiting
Mindfulness for stress and high blood pressure
This study tests if a mindfulness program can help lower stress and blood pressure in people living in Chicago's South Side. You may join if you have high blood pressure and feel down or depressed.
Chicago, IllinoisAges 18 years+ - NCT06988410Recruiting
Income changes and mental health study
This study looks at how ups and downs in income affect mental health. If you're a woman between 18 and 60 living with up to 4 other adults, you may be able to join.
TamaleAges 18–60 - NCT06994988Recruiting
Smart band-aid study for chronic pain in women
This trial tests a special band-aid that measures chronic pain. Women with chronic pain or healthy women may join to help researchers learn how this device works.
Chicago, IllinoisAges 18 years+ - NCT07014852RecruitingEarly Phase 1
Inuit mental health trial with cultural foods and activities
This trial tests whether a program that includes traditional country foods, group conversations, and cultural workshops can improve mental health for Inuit adults. It is designed with Inuit knowledge to make the study feel supportive and relevant.
Arviat, NunavutAges 18–65 - NCT07024979Recruiting
Music therapy for university students' mental health
This trial tests whether a music therapy program can help university students with moderate stress, social problems, or trouble adjusting to college life. It aims to improve your mental health and well-being.
Hong KongAges 18–35 - NCT07025590Recruiting
Exercise to help lower antidepressants for heart patients
This trial tests whether adding a structured exercise program can help people with both depression/anxiety and heart disease slowly reduce their antidepressant medication. It may offer a way to lower medication use while improving heart and mental health.
Guangzhou, GuangdongAges 18–70 - NCT07029126Recruiting
Fremanezumab for migraine with depression: caregiver impact study
This trial tests if fremanezumab, a migraine prevention drug, can also reduce the stress and improve the relationship between migraine patients with mild depression and their caregivers. If you or someone you care for has migraines and low mood, this study may help understand how the caregiver is affected.
Rome, ItalyAges 18 years+ - NCT07031661Recruiting
Bipolar disorder risk study for teens and children
This study follows children and teens who may be at higher risk for bipolar disorder to develop a prediction model. It includes three groups: those with a parent who has bipolar disorder, those with atypical depression, and healthy volunteers.
Shanghai, Shanghai MunicipalityAges 6–18
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.