Clinical trials
Direct Oral Anticoagulants (DOACs) clinical trials
Below are recruiting direct oral anticoagulants (doacs) clinical trials, each written for real people, not researchers. We’re tracking 25 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04284839RecruitingPhase 3
Blood thinner pills vs warfarin after heart surgery
This trial compares two ways to prevent blood clots after open heart surgery: a “direct oral” blood thinner pill versus warfarin (a vitamin K antagonist). It may help find the safest and most effective option for people who develop atrial fibrillation after surgery.
Fitzroy, VictoriaAges 18 years+ - NCT07520890Recruiting
Bleeding Risk During Oral Biopsies in Patients on Blood Thinners
This study looks at whether patients taking certain blood-thinning medications (DOACs) have more bleeding during oral biopsies—small tissue samples taken from the mouth. Understanding this helps doctors know how to safely care for patients on these medications.
Pisa, PiAges 18 years+ - NCT04660747Recruiting
Anticoagulant medication choices for cerebral venous thrombosis
This study looks at people with cerebral venous thrombosis who were treated with blood thinners taken by mouth (or started within the first 30 days). It uses observational data to understand how these treatments are used and what outcomes may follow.
Amsterdam, North HollandAges 18 years+ - NCT04977076Recruiting
Stopping versus continuing blood thinner during heart catheter procedures
This study compares whether you should temporarily stop your blood thinner (DOAC) or keep taking it when you have an elective heart catheter test or procedure (coronary angiography or PCI). It aims to see which approach is safer and better for preventing bleeding and clotting around the procedure.
Heerlen, LimburgAges 18 years+ - NCT05498428RecruitingPhase 2
Amivantamab for advanced lung cancer with EGFR mutations
This Phase 2 study tests amivantamab (an antibody medicine) in people with advanced or metastatic non-small cell lung cancer that has specific EGFR gene changes. It may help shrink tumors or control cancer when standard curative treatments aren’t possible.
La Jolla, CaliforniaAges 18 years+ - NCT06322953RecruitingPhase 3
Timing to restart blood thinners after head injury bleeding
This trial looks at when it is safest to restart blood thinners after a traumatic brain bleed. It compares restarting at 4 weeks versus 8 weeks in people on blood thinners before their injury.
Plymouth, DevonAges 18 years+ - NCT06869811Recruiting
Stroke prevention after failed blood thinners
This study is for people who had a stroke despite taking blood thinners for atrial fibrillation. It tests if adding a procedure to close the left atrial appendage (a small pouch in the heart) to your blood thinner is better than just taking the blood thinner alone to prevent another stroke.
Barcelona, BarcelonaAges 18–95 - NCT06957366Recruiting
Managing Blood Thinners Before High-Risk Surgery
This study looks at how to safely manage your blood thinner (DOAC) around the time of a planned, high-bleed-risk surgery or procedure involving a spinal needle. The goal is to find the best way to stop and restart your medication to prevent bleeding and clotting problems.
Hartford, ConnecticutAges 18 years+ - NCT07309848Recruiting
Hip fracture surgery timing and blood transfusion risk on DOACs
This study looks at whether the timing of hip fracture surgery affects the need for blood transfusions in patients taking blood thinners (DOACs). It might help guide better care for people on these medications.
AlmeloAges Any age - NCT07559942Recruiting
Apiban to Help Dialysis Fistulas Mature Successfully
This trial tests whether a blood-thinner medication called apixaban (Apiban) helps arteriovenous fistulas—surgically created connections in the arm for dialysis—develop and work better. If it helps fistulas mature faster and more reliably, it could reduce complications and improve treatment for kidney failure patients.
Lahore, Punjab ProvinceAges 18 years+ - NCT07242326Enrolling by invitation
Blood Thinner Dose Check for Older Adults With AFib
This study looks at whether older adults with atrial fibrillation are taking the right dose of their blood thinner medicine. It aims to improve how doctors prescribe these medications in primary care.
Ordu, OrduAges 65 years+ - NCT05723926Recruiting
Carotid implants to help prevent stroke repeat in atrial fibrillation
This trial tests whether placing a carotid implant can reduce the chance of having another stroke in people with atrial fibrillation who are already taking blood thinners. It aims to prevent stroke recurrence while you continue prescribed anticoagulation.
Rockford, IllinoisAges 18 years+ - NCT06823466Recruiting
Stroke study for patients on blood thinners
This study looks at people who had a stroke while taking blood thinners (anticoagulants) for an irregular heartbeat. It aims to learn more about these strokes and how to better prevent them in the future.
ZagrebAges 18 years+ - NCT06482333Recruiting
When to restart blood thinners after polyp removal
This trial looks at the best time to restart direct oral anticoagulants (blood thinners) after having polyps removed during a colonoscopy. It aims to find a balance between preventing bleeding and reducing the risk of blood clots.
Hong KongAges 40 years+ - NCT05169242Recruiting
Preventing bleeding after colonoscopy using preventive clip placement
This trial tests whether placing small “preventive clips” during colonoscopy can reduce bleeding afterward in people who take blood thinners (DOACs). It may help lower the chance of bleeding after polyp removal or biopsy during a scheduled colonoscopy.
Shatin, New TerritoriesAges 18 years+ - NCT06571149RecruitingPhase 4
Blood thinners and clot-busting drugs for stroke
This trial tests whether giving a clot-dissolving medicine (alteplase or tenecteplase) is safe and effective for people who have had a stroke and are taking a blood thinner (DOAC) like apixaban or rivaroxaban. It aims to see if this treatment can still be given within a few hours of the stroke.
EisenstadtAges 18 years+ - NCT05070169Recruiting
Early surgery for hip fractures in people on blood thinners
This study looks at whether fixing a hip fracture sooner is better for people who take a direct oral anticoagulant (DOAC) blood thinner. It compares early surgery versus delayed surgery in people whose delay is specifically from the blood thinner.
ViennaAges 18 years+ - NCT05198960RecruitingPhase 3
Blood thinner drugs vs aspirin to prevent clot problems
This trial compares apixaban or rivaroxaban (blood thinners) against aspirin to prevent future clot-related complications in people with certain bone marrow diseases (PV, ET, or pre-PMF) that have a specific JAK2 mutation. It may help lower the risk of clots, but it also carefully considers bleeding risk.
AngersAges 18 years+ - NCT06556446Recruiting
Clot-busting drug after stroke if on blood thinner
This study looks at whether giving a clot-busting medicine (IV thrombolysis) is safe and effective for people who have had a stroke and also recently took a direct oral anticoagulant (DOAC). If you've taken a DOAC in the last 48 hours, this trial may help doctors decide the best treatment for you.
InnsbruckAges 18 years+ - NCT07083609Recruiting
Blood thinners for brain vein clots in Vietnam
This trial tests a type of blood thinner called DOACs for people with a clot in a brain vein (cerebral venous thrombosis). DOACs may be an easier treatment option, and this study looks at how well they work in adults in Vietnam.
HanoiAges 18 years+ - NCT07159399Enrolling by invitation
Pharmacist-led education to help patients take blood thinners
This trial tests if talking with a pharmacist helps people with atrial fibrillation remember to take their blood thinner medicine correctly. It may improve stroke prevention.
TaipeiAges 18 years+ - NCT05955365RecruitingPhase 4
Single anticoagulant blood thinner after stent in atrial fibrillation
This trial tests whether taking a single “P2Y12 inhibitor” blood thinner (instead of multiple medicines) is safe and effective after you get a coronary stent. It’s for people with atrial fibrillation who need long-term blood thinning and have recently had a successful stent procedure.
HasseltAges 18 years+ - NCT03297281Recruiting
Stopping or continuing blood thinners during prostate vaporization
This study compares whether people can safely stop or continue oral blood thinners during a prostate procedure called photovaporization. It may help reduce bleeding risk without increasing dangerous clot risks for the right patients.
ToulouseAges 18 years+ - NCT05712200RecruitingPhase 3
Abelacimab for atrial fibrillation when blood thinners aren’t suitable
This Phase 3 study tests whether abelacimab can prevent stroke and other blood-clot problems in people with atrial fibrillation (or atrial flutter) who cannot safely take usual mouth blood thinners. It also looks at safety, especially bleeding risk.
Birmingham, AlabamaAges 65 years+
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Common questions
- Are there clinical trials for direct oral anticoagulants (doacs)?
- Yes. Clin2 currently lists 25 recruiting direct oral anticoagulants (doacs) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a direct oral anticoagulants (doacs) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a direct oral anticoagulants (doacs) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.