Clinical trials · Massachusetts
Down Syndrome clinical trials in Massachusetts
We’re tracking 156 recruiting down syndrome studies with a site in Massachusetts — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT05922761RecruitingPhase 2
Belumosudil for lung scar prevention or treatment after transplant
This Phase 2 study tests belumosudil to treat or prevent bronchiolitis obliterans (BOS), a lung complication that can happen after a stem cell transplant. If you qualify, you would be checked closely with breathing tests and scans, and watched for safety and whether lung function improves or stays stable.
Boston, MassachusettsAges 18 years+ - NCT05905328RecruitingPhase 1/Phase 2
New drug to prevent and treat side effects of CAR T-cell therapy
This study tests an experimental drug, CTO1681, that may help prevent or treat cytokine release syndrome (CRS) — a common side effect of CAR T-cell therapy. It could make the recovery period safer and more comfortable.
Boston, MassachusettsAges 18 years+ - NCT05801224Recruiting
Inhaled nitric oxide for lung injury in intensive care
This study tests whether giving inhaled nitric oxide gas helps improve lung function in patients on a breathing tube with mild to moderate acute lung injury (ARDS). Participants will receive standard care plus the study gas, and the team will use special imaging to see how the lungs respond.
Boston, MassachusettsAges 18–80 - NCT05767658Recruiting
Online messages to support safer infant care
This study tests whether online social network posts and text messages can help pregnant people practice safer infant care after birth. It may help you feel more prepared about feeding and safe sleep.
Boston, MassachusettsAges Any age - NCT05737121RecruitingPhase 2
Study drug for bladder pain compared with lidocaine, heparin, or placebo
This Phase 2 trial tests VNX001 to see if it helps people with interstitial cystitis/bladder pain syndrome (IC/BPS) compared with its separate ingredients (lidocaine and heparin) or a placebo (inactive treatment). You may be eligible if you have had IC/BPS for months and recently had a moderate-to-severe bladder pain flare.
Watertown, MassachusettsAges 18 years+ - NCT05724173Recruiting
Test of a brain-to-computer device for ALS hand paralysis
This study checks whether a brain-computer interface (a BrainGate2 system) is safe and workable for people with ALS. If you qualify, you may be asked to try the device and complete study tasks to help researchers learn how well it can support communication or control.
Boston, MassachusettsAges 18–80 - NCT05604430Enrolling by invitation
Study of pre-hospital breathing support with a specific ventilator
This study looks at breathing support given outside the hospital using a particular ZOLL ventilator model and software version. If you were treated with the right equipment, the team will use the ventilator’s recorded data to evaluate how ventilation was delivered.
Uxbridge, MassachusettsAges Any age - NCT05635747Enrolling by invitation
90-day follow-up study for children using RELiZORB
This study follows children who are already taking RELiZORB to see how it’s going over time and whether it remains safe and tolerable, with effects on nutrient absorption. It doesn’t change treatment—it mainly looks at outcomes during the next 90 days.
Boston, MassachusettsAges 2–18 - NCT05564390RecruitingPhase 2
MyeloMATCH screening to match you to AML or MDS treatment
This study screens people with newly suspected acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) to see which treatment approach fits best—either a specific study treatment or standard care. It may help by directing you to the right option and by sharing your blood/bone marrow samples for research.
Boston, MassachusettsAges 18 years+ - NCT00389142Recruiting
Find genes linked to bladder pain and urinary symptoms
This study looks for genetic (inherited) causes of bladder pain syndrome (IC/BPS), using information from people who have typical urinary symptoms. It may help doctors understand why IC/BPS happens, which could guide better future care.
Boston, MassachusettsAges 1 year+ - NCT05462106RecruitingPhase 1/Phase 2
ACI-24.060 study for early Alzheimer’s in adults and Down syndrome
This Phase 1/2 study tests an Alzheimer’s treatment called ACI-24.060 to see if it affects the disease in people with early Alzheimer’s changes. It includes two groups: older adults with early symptoms and people with Down syndrome who also show Alzheimer’s-related changes on brain scans.
Boston, MassachusettsAges 35–85 - NCT05463796Recruiting
Prevention and early detection for people at high cancer risk
This study looks at surveillance (watching closely), prevention, and early “interception” steps to lower the chance that cancer will develop or be found later. It is for people with genetic risk, past cancer treatment exposures, strong family history, or certain early pre-cancer or high-risk conditions.
Boston, MassachusettsAges Any age - NCT05412862Recruiting
Improving mood after a recent heart event
This study looks at whether increasing positive emotions after an acute heart problem (like a heart attack or unstable angina) can help patients feel and function better. You may be eligible if you had a recent heart event and are not currently getting enough physical activity.
Boston, MassachusettsAges 18–95 - NCT05209568Enrolling by invitation
Study of immune reactions after eating gluten
This study looks at how your immune system responds when you eat gluten, including for people with celiac disease. You may be asked to follow a gluten-free diet first and then safely reintroduce gluten so researchers can measure immune changes.
Boston, MassachusettsAges 2–101 - NCT05003986RecruitingPhase 2
Sparsentan for children with protein leaking kidney diseases
This Phase 2 study tests sparsentan in children with certain kidney diseases that cause high amounts of protein in the urine. It aims to see if the medicine can reduce kidney damage signals and protein leakage compared with standard care.
Boston, MassachusettsAges 1–17 - NCT04988555RecruitingPhase 1/Phase 2
Study of an investigational drug for high-risk acute leukemia
This Phase 1/2 study tests enzomenib (DSP-5336) in people with relapsed or hard-to-treat acute leukemia (and, in some places, certain other blood cancers). The goal is to see how the drug works and how safe it is, especially for leukemia cases with specific genetic changes (KMT2A/MLL or NPM1).
Boston, MassachusettsAges 12 years+ - NCT04775706RecruitingPhase 2
Test of sonefpeglutide for people with short bowel syndrome
This Phase 2 study tests whether sonefpeglutide is safe and how the body handles it (pharmacokinetics) in people with short bowel syndrome. It may help people who still need nutrition through a tube because their intestinal condition is stable.
Boston, MassachusettsAges 18 years+ - NCT04771572RecruitingPhase 1
Oral drug LP-118 for relapsed blood cancers
This Phase 1 study tests an oral (by mouth) drug called LP-118 in people whose blood cancers have returned or did not respond to prior treatment. The goal is to find a safe dose and see whether it can shrink or control the cancer.
Boston, MassachusettsAges 13 years+ - NCT04546399RecruitingPhase 2
Blinatumomab with or without nivolumab for first relapse ALL
This study compares blinatumomab alone versus blinatumomab plus nivolumab in young people whose B-cell ALL has returned for the first time. It aims to see whether adding nivolumab improves control of the leukemia after relapse.
Boston, MassachusettsAges 1–30 - NCT04256317RecruitingPhase 2/Phase 3
Azacitidine pills with or without venetoclax for certain blood cancers
This study tests whether a pill form of azacitidine (ASTX030) helps people with myelodysplastic syndromes (MDS), CMML, or AML. Some groups may also receive venetoclax; the goal is better blood cancer control for people who aren’t good candidates for intensive chemotherapy.
Boston, MassachusettsAges 18 years+ - NCT04064060RecruitingPhase 3
Long-term safety follow-up for luspatercept study participants
This trial studies the long-term safety of luspatercept (ACE-536) in people who already took part in an earlier luspatercept study. It mainly helps doctors better understand ongoing side effects and overall safety over time.
Boston, MassachusettsAges 18 years+ - NCT04049331RecruitingPhase 2
Testosterone therapy for cancer survivors with fatigue
This trial tests whether testosterone replacement can help male cancer survivors who have ongoing fatigue and low testosterone levels. It is for men who have completed chemotherapy or radiation and are cancer-free for at least a year.
Boston, MassachusettsAges 18–54 - NCT04024761RecruitingPhase 1
NK cell therapy for leukemia relapse after transplant
This Phase 1 study tests whether an infusion of special immune cells (NK cells) from a donor can help control leukemia or related blood cancers that come back or do not fully go away after a stem cell transplant. It also uses short chemotherapy to “make space” for the NK cells to work, and IL-2 to help them function.
Boston, MassachusettsAges 12 years+ - NCT02967068Recruiting
Share your study tissue for future research
This study is a “tissue repository” that collects and stores leftover tissue from other approved VCRC studies. If you already took part in one of those studies, you may be able to let researchers use your tissue to help answer future questions.
Boston, MassachusettsAges Any age
Down Syndrome trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting down syndrome studies listed above.
- Dana-Farber Cancer Institute · 6 studies
- Massachusetts General Hospital · 5 studies
- Boston Children's Hospital · 4 studies
- Brigham and Women's Hospital · 4 studies
- Tufts Medical Center · 3 studies
- Beth Israel Deaconess Medical Center · 2 studies
- Bay State Clinical Trials
- Boston Children's Hospital (BCH)
What taking part in a down syndrome study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Down Syndrome trials in other states
Common questions
- Are there down syndrome clinical trials in Massachusetts?
- Yes. We're currently tracking 156 recruiting down syndrome studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a down syndrome study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New down syndrome studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.