Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07604103RecruitingPhase 3
Heart Attack and Pneumonia Recovery Study With Vaccination
This study looks at blood markers (special proteins) in patients who have had both a heart attack and pneumonia, to see how vaccination affects recovery. The goal is to understand whether flu and pneumonia vaccines are safe and helpful for people recovering from these two serious conditions together.
Malang, East JavaAges 18–65 - NCT06518005RecruitingPhase 2
Gene therapy for severe Crigler-Najjar syndrome
This trial tests a new gene therapy called GNT0003, given after a pre-treatment to help it work, for people with severe Crigler-Najjar syndrome. The goal is to see if it can reduce the need for daily light treatments.
ClamartAges 18 years+ - NCT06248151Recruiting
Exercise and heart health after COVID-19
This study looks at how a single exercise session affects the heart and blood vessels in people with lasting COVID-19 symptoms. It may help understand if exercise is safe and helpful for recovery.
São PauloAges 18 years+ - NCT07598422Recruiting
Safety and Effectiveness of Canakinumab for Schnitzler's Syndrome
This study tracks how well and safely canakinumab (a medication that reduces inflammation) works in patients newly diagnosed with Schnitzler's syndrome. Schnitzler's syndrome is a rare condition causing recurring fevers, rashes, and joint pain, and this study helps doctors understand how this drug performs in real-world use.
Kobe, HyōgoAges birth+ - NCT07599306Recruiting
Telehealth Rehabilitation for Heart Patients After ICU Recovery
This study tests whether supervised remote rehabilitation exercises can help people recover better after a long ICU stay. Many patients struggle with weakness, memory problems, or mood changes after intensive care—this trial aims to improve those symptoms through video-guided therapy.
Milan, MilanoAges 30–75 - NCT07603154Enrolling by invitation
Massage therapy for superior cluneal nerve pinching
This trial tests a specific massage technique called 'Fenjin Tuina' for treating superior cluneal nerve entrapment syndrome, a condition where a nerve in the lower back and hip area becomes pinched or compressed. The study aims to see if this traditional Chinese massage approach can reduce pain and improve function.
Guangzhou, GuangdongAges 18–70 - NCT07598643RecruitingPhase 2
Study of tofacitinib for immune function in Down syndrome
This study tests if an oral medication called tofacitinib can help the immune system work better in children and young adults with Down syndrome, which may improve learning and development. The study will follow participants for 6 months.
Aurora, ColoradoAges 6–22 - NCT07603310Recruiting
PEEP levels in ARDS based on lung response
This study tests whether adjusting ventilator settings based on how well your lungs respond can improve oxygen and reduce damage in patients with moderate to severe ARDS, within the first 36 hours of diagnosis.
Rancagua, Región del Libertador General Bernardo O’HigginsAges 18 years+ - NCT06007027Recruiting
Vaginal laser therapy for breast cancer survivors with menopause symptoms
This trial tests whether a vaginal laser treatment can help breast cancer survivors who have menopause-like symptoms such as vaginal dryness or pain during sex. It is designed for women currently on hormone-blocking therapy.
RandersAges 18–100 - NCT07593391RecruitingPhase 3
NNZ-2591 Treatment for Children with Phelan-McDermid Syndrome
This study tests whether a medication called NNZ-2591 can help children with Phelan-McDermid syndrome, a rare genetic condition that affects brain development and learning. Researchers want to see if this drug can improve how children with this condition develop and learn.
Birmingham, AlabamaAges 3–12 - NCT07588061Recruiting
Neck Pain Treatment: Mobilization and Posture Exercises
This study tests whether combining two types of physical therapy—manual joint mobilization and specific posture-strengthening exercises—can reduce neck and upper back pain and improve how you hold your body. You may qualify if you have persistent neck pain linked to poor posture.
Peshawar, KPKAges 18–45 - NCT07586553Recruiting
Walking Test Study for Older Adults With Memory Concerns
This study tests a special walking pattern called the figure-of-8 walk in older adults who are noticing memory problems but don't have dementia yet. Researchers want to understand how walking ability connects to thinking and memory changes.
Balıkesir, BigadiçAges 65 years+ - NCT06720571Recruiting
Nerve stimulation for emotion and thinking in Prader-Willi syndrome
This trial tests whether a gentle, non-invasive nerve stimulation (like a small device on the neck) can help people with Prader-Willi syndrome regulate emotions and improve planning and focus. It may be a new option if you have trouble with emotional control or daily organization.
BordeauxAges 18 years+ - NCT07585097Recruiting
Long-term Safety Study of Odevixibat for Alagille Syndrome
This study follows patients with Alagille syndrome who are taking odevixibat to see how safe the medicine is over time. Alagille syndrome is a rare liver disease that affects bile flow, and odevixibat is a treatment that may help reduce itching and improve liver function.
BronAges 6 months+ - NCT07577492Recruiting
Neck Position Sense and Balance in Students With Rounded Shoulders
This study examines how neck position awareness, core strength, and balance are affected in university students with Upper Crossed Syndrome—a posture problem involving forward head position and rounded shoulders. The research may help identify better treatments for chronic neck pain linked to poor posture.
Istanbul, TopkapiAges 18–30 - NCT07584278Recruiting
Probiotics and Biomarkers for Irritable Bowel Syndrome
This study tests whether probiotics (beneficial bacteria) can help reduce irritable bowel syndrome (IBS) symptoms and change certain markers in your gut. You'll take a probiotic supplement for 12 weeks while researchers track how your symptoms and gut health change.
GothenburgAges 18 years+ - NCT07578168Enrolling by invitation
Kinesio Tape for Rotator Cuff Shoulder Pain
This study tests whether kinesiology tape (a special stretchy tape applied to the skin) can reduce pain and improve function in people with rotator cuff syndrome, a common shoulder condition. You'll be randomly assigned to receive the tape or a control treatment and tracked over several weeks.
Kırşehir, MerkezAges 18–65 - NCT07584083RecruitingPhase 2
Anifrolumab for Primary Antiphospholipid Syndrome
This trial tests a new drug called anifrolumab in adults with primary antiphospholipid syndrome (a blood clotting disorder). The drug may help reduce clotting and related complications by working with your immune system.
Athens, GreeceAges 18–70 - NCT07578831Recruiting
Neck Pain Relief: Comparing Two Exercise Methods
This study compares two types of therapeutic exercises—Kendall and Feldenkrais—to help reduce neck pain and improve posture in people with upper crossed syndrome (a common postural condition where neck and shoulder muscles become tight and weak). You'll do one type of exercise program to see which helps your neck pain and function better.
Lahore, Punjab ProvinceAges 20–50 - NCT03988764Recruiting
Checking monogenic diabetes wrongly labeled as type 1
This trial looks at people who were diagnosed with diabetes before age 25 as either type 1 or “not sure which type.” It may help confirm whether the cause is genetic (monogenic) rather than type 1, which can change treatment choices.
Montreal, QuebecAges 1 day–25 years - NCT07573553Recruiting
Rib Mobilization and Posture Exercises for Upper Crossed Syndrome
This study tests whether combining rib mobilization (hands-on therapy to improve rib movement) with posture-correction exercises can reduce neck pain and improve posture in people with upper crossed syndrome (a postural condition causing rounded shoulders and forward head tilt). It may help you understand if this combination therapy works better than standard treatment.
Chak Six Hundred Twenty-four, Khyber PakhtunkhwatAges 20–45 - NCT07569731Recruiting
Understanding Fibrous Dysplasia Through Patient Data and Tissue
This study collects information from patients with fibrous dysplasia (a bone condition where normal bone is replaced by fibrous tissue) and related syndromes to better understand the disease. Researchers will review your medical records, imaging scans, and stored tissue samples to learn more about how the disease develops and progresses.
Bologna, BOAges Any age - NCT07569445Recruiting
Brain activity and hearing tests in Rett syndrome
This study measures brain waves and hearing in people with Rett syndrome to better understand how the condition affects the brain's ability to process sound. The information may help develop better treatments and support.
Rochester, New YorkAges 2 years+ - NCT07573527Recruiting
Online therapy for upper back muscle pain from trigger points
This study tests whether remote physical therapy (done online) can help relieve neck and upper back pain caused by tight knots in your rhomboid muscles. You would receive guided exercises and treatment through video calls instead of visiting a clinic in person.
Karachi, SindhAges 18–35
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.