Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,187 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07703371Recruiting
Kodo millet porridge and its effect on gut health and metabolic syndrome
This study tests whether eating Kodo millet porridge every day for 12 weeks can improve gut health and reduce risk factors for metabolic syndrome (like being overweight). If you are between 20 and 60 years old, are overweight or obese, and are willing to eat the porridge daily without changing your diet or exercise, you may be able to join.
Mysore, KarnatakaAges 20–60 - NCT07577492Recruiting
Neck Position Sense and Balance in Students With Rounded Shoulders
This study examines how neck position awareness, core strength, and balance are affected in university students with Upper Crossed Syndrome—a posture problem involving forward head position and rounded shoulders. The research may help identify better treatments for chronic neck pain linked to poor posture.
Istanbul, TopkapiAges 18–30 - NCT05640271RecruitingPhase 2
Tocilizumab for acute chest syndrome in sickle cell
This trial studies tocilizumab (a medicine that calms inflammation) to treat acute chest syndrome in people with sickle cell disease. It may help improve symptoms and recovery by targeting key immune signals involved in this complication.
Chicago, IllinoisAges 12 years+ - NCT07698925Recruiting
Breathing exercises for sleep problems in PCOS
This trial tests if simple diaphragmatic breathing exercises can improve sleep for women with Polycystic Ovarian Syndrome (PCOS) who have trouble sleeping. If you have PCOS and poor sleep, this gentle, non-drug approach might help.
Cairo, Cairo GovernorateAges 25–35 - NCT04018118Recruiting
Study of the course of high eosinophil blood disease
This study follows people with long-term high eosinophils (a type of white blood cell) and related conditions to learn how the illness changes over time. It helps doctors understand patterns of organ involvement and outcomes, which may improve future care.
LilleAges Any age - NCT04087421RecruitingPhase 3
Transanal irrigation vs glycerol suppositories for LARS
This trial compares two ways to help bowel control in people with low anterior resection syndrome (LARS) after low rectal surgery. It aims to see which option works better when standard treatments have not helped enough.
AarhusAges 18 years+ - NCT04087200Recruiting
High-dose statin early after heart attack to protect kidneys
This trial looks at whether starting a high dose of a statin (cholesterol medicine) right away after an acute coronary syndrome (a serious heart condition) can reduce future heart and kidney problems. It may help patients by testing a strategy meant to prevent complications soon after the event.
PratoAges Any age - NCT04133272Recruiting
Registry for Ehlers-Danlos syndrome patients and pregnancies
This study is a registry that collects information about people with Ehlers-Danlos syndrome, including unborn babies diagnosed before birth. It may help researchers learn more about the condition and improve care over time.
Bologna, Emilia-RomagnaAges Any age - NCT04134572Recruiting
Registry for Ollier disease and Maffucci syndrome
This trial is a registry, which means it collects information about people with Ollier disease and Maffucci syndrome. It can help researchers better understand these conditions and plan future studies.
Bologna, Emilia-RomagnaAges Any age - NCT04165109Recruiting
Down syndrome study to test memory and thinking changes
This study enrolls adults with Down syndrome to better understand how thinking and memory develop and change over time. It may help by building a “trial-ready” group and by measuring thinking in a careful, consistent way.
Phoenix, ArizonaAges 25–55 - NCT04167696RecruitingPhase 1
Dose-finding drug study for AML or MDS after standard options fail
This Phase 1 trial tests CYAD-02 to find the safest and recommended dose for people with AML or MDS that has returned or did not respond to prior treatment. It may help if you have limited treatment options, but participation also requires meeting specific heart, lung, and lab safety requirements.
Jacksonville, FloridaAges 18 years+ - NCT04187703RecruitingEarly Phase 1
Testing azacitidine and decitabine for bone marrow cancers
This early-phase study tests whether combining two “epigenetic” medicines—azacitidine and decitabine—can improve outcomes for certain bone marrow cancers. It may help if you have a type of myelodysplastic syndrome (MDS) or MDS/MPN overlap that is expected to be sensitive to these medicines.
Cleveland, OhioAges 18 years+ - NCT04203979Recruiting
Sepsis care tailored to patients
This study looks at how to better recognize and manage sepsis (a serious body-wide reaction to infection) and tailor care to the individual. You may be eligible if you are newly admitted to the emergency department and your care is handled by a rapid response team for sepsis.
OsloAges 18 years+ - NCT04217733RecruitingPhase 3
Ethosuximide plus pentoxifylline for IBS belly pain
This Phase 3 study tests whether two medicines (ethosuximide and pentoxifylline) can reduce belly pain from irritable bowel syndrome (IBS). It may help people whose IBS pain has been moderate to severe recently and who can keep their current IBS treatment steady.
TantaAges 18 years+ - NCT04232085RecruitingPhase 2
Stem cell transplant to rebuild immunity in genetic immune disorders
This Phase 2 trial tests a stem cell (bone marrow) transplant approach to restore bone marrow function and immune function in people with certain inherited immune problems. If you have one of these conditions and a suitable donor, the study may offer a path to rebuild blood and immune systems.
Baltimore, MarylandAges 4 months–50 years - NCT04240834RecruitingPhase 4
Low-dose ticagrelor vs aspirin after heart stent placement
This study compares ticagrelor taken at a lower dose versus regular aspirin to help prevent future heart attacks in people who recently had a stent placed after acute coronary syndrome. You may qualify if you’re considered “high risk” for new blockages or clots and can take dual anti-platelet therapy for 12 months.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04245397RecruitingPhase 1
Test drug SX-682 with decitabine for myelodysplastic syndrome
This Phase 1 trial tests whether SX-682 given alone or with decitabine can treat myelodysplastic syndrome (MDS) that has not responded well to prior therapy. It also studies safety and the best dose, which may help people who have limited treatment options.
Jacksonville, FloridaAges 18 years+ - NCT04243785RecruitingPhase 1
Testing BTX-A51 for hard-to-treat AML or high-risk MDS
This Phase 1 study tests BTX-A51 in adults with relapsed or refractory acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). It’s designed to see if the treatment can be given safely and to learn how it works in people whose standard treatments have not helped or are no longer an option.
Duarte, CaliforniaAges 18 years+ - NCT04256018RecruitingPhase 2
Mogamulizumab with low-dose skin radiation for lymphoma skin disease
This Phase 2 study tests mogamulizumab together with low-dose total skin electron beam radiation to treat mycosis fungoides or Sézary syndrome, two types of skin lymphoma. It may help shrink skin disease and control symptoms by combining an immune-targeting medicine with skin-focused radiation.
Stanford, CaliforniaAges 18 years+ - NCT04271878Recruiting
Test breathing and blood-pressure response in POTS patients
This study measures how breathing patterns and heart rate/blood pressure change when you move from lying to standing in people with POTS. It may help researchers understand symptoms better and improve ways to manage them.
Calgary, AlbertaAges 18–60 - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Phoenix, ArizonaAges birth–20 years - NCT04323904Recruiting
Hantavirus registry for people with kidney or lung symptoms
This study is a registry, meaning it collects health information and possibly test results from people who have evidence of hantavirus infection along with specific illness symptoms. It may help researchers better understand how hantavirus affects the kidneys or the heart/lungs (and how to recognize it).
Cologne, North-Rhine WestfaliaAges Any age - NCT04330118Recruiting
Study immune cells in DRESS and drug rash reactions
This trial studies how certain immune cells (eosinophils) behave during severe drug reactions like DRESS and during milder drug rashes. It may help doctors understand what drives organ damage and improve how these reactions are managed.
ArrasAges 18 years+ - NCT04355572Recruiting
Vitamin D replacement study for teens at risk of PCOS
This study looks at how taking vitamin D affects hormone levels and emotional well-being in teen girls who may develop PCOS. If you have low vitamin D and meet PCOS risk criteria, the study may test whether vitamin D helps you feel and function better.
New Haven, ConnecticutAges 13–21
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,187 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.