Clinical trials
Effectiveness clinical trials
Below are recruiting effectiveness clinical trials, each written for real people, not researchers. We’re tracking 6,374 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04743791RecruitingPhase 4
Dupilumab study for clearing mucus in moderate to severe asthma
This study tests whether dupilumab improves how well mucus is cleared from the airways in adults with moderate to severe asthma. It may help find better ways to reduce mucus-related breathing problems in people with a specific asthma type.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04734756Enrolling by invitation
Dragonfly device study for leaking mitral valve in high-risk patients
This trial tests the safety and effectiveness of a heart procedure that repairs a leaking mitral valve through thin tubes, using the Dragonfly system. It’s for people who have significant mitral valve leak symptoms but are considered high risk for open-heart surgery.
Hangzhou, ZhejiangAges 18 years+ - NCT04684901Enrolling by invitation
AlloWrap to reduce inflammation during cervical spine fusion surgery
This trial tests whether AlloWrap® can lower inflammation during anterior cervical fusion surgery (ACDF). It may help improve healing and recovery by reducing the body’s inflammatory response after surgery.
San Diego, CaliforniaAges 18 years+ - NCT04671771Recruiting
Testing a new graft for hemodialysis access in kidney failure
This study tests whether an “AV graft” implant works safely and well for people with end-stage kidney disease who need hemodialysis. It may help your dialysis access last and work better, compared with current expectations for AV grafts.
Phoenix, ArizonaAges 18–90 - NCT04630392Recruiting
Treadmill and vibration therapy for children with spastic cerebral palsy
This study tests whether treadmill training, with or without whole-body vibration, can improve walking and movement in children with spastic cerebral palsy. If you qualify, the goal is to see whether this exercise approach is safe and helpful.
Atlanta, GeorgiaAges 6–17 - NCT04621279Recruiting
Cooling treatment study for babies with mild brain injury
This study compares different approaches to “cooling” treatment in newborns with mild hypoxic-ischemic encephalopathy (mild brain injury from not enough oxygen around birth). The goal is to see which approach works best and is safest for babies like yours.
Dallas, TexasAges 8 months+ - NCT04659343Recruiting
Testing tumor care planning for metastatic kidney cancer
This trial studies a way to plan and manage care for people with metastatic renal cell carcinoma (kidney cancer that has spread). It may help doctors coordinate treatment more effectively to improve outcomes.
Aarhus, DanmarkAges 18 years+ - NCT04601038RecruitingPhase 2
Testing a stress-blocking drug for early Alzheimer's risk
This study tests a new medication, CORT108297, that may help protect the brain from the harmful effects of stress in people at risk for Alzheimer's disease. It is looking for adults age 55 and older who either have mild memory problems or are healthy but have a family history, APOE4 gene, or memory concerns.
Baltimore, MarylandAges 55 years+ - NCT04619836Enrolling by invitation
Study of diabetes care plans and cost-effectiveness
This trial looks at how well a diabetes care plan works and how cost-effective it is for people with type 2 diabetes. You may be included if your diabetes care and self-management are arranged using a specific care-planning approach.
TampereAges 18–90 - NCT04504955Recruiting
Atopic dermatitis patient registry for medication safety and results
This study is a real-world registry that collects information from adults with atopic dermatitis (eczema) to track how newly started treatments work and how safe they are over time. It may help researchers and doctors better understand medication effects in everyday care.
Waltham, MassachusettsAges 18 years+ - NCT04551378Recruiting
Study of how COVID affected young people with cancer
This study looks at how the COVID-19 pandemic affected the experiences of teenagers and young adults with cancer, including people who finished treatment. It may help improve support for cancer patients and survivors during public health crises.
Houston, TexasAges 18–39 - NCT04576078RecruitingPhase 2
Nefopam for less pain after knee replacement surgery
This Phase 2 study tests whether oral nefopam can reduce pain after total knee replacement done with spinal anesthesia. It looks at whether this medicine works better than the usual post-surgery pain plan and how safely it can be used.
Lyon, LyonAges 18–75 - NCT04578249Recruiting
Blocking blue light at night after heart surgery
This trial tests whether reducing blue light at night after certain planned heart surgeries helps protect mood, thinking, and recovery. If you have no history of major mental health problems or organ problems, you may be able to join the study.
Morgantown, West VirginiaAges 45–75 - NCT04505865Recruiting
Mindfulness program to reduce inflammation in heart disease
This trial studies whether a mindfulness (stress-reducing) program can lower “vascular inflammation” (inflammation in blood vessel walls) in people with stable coronary disease. It may help by improving stress and related inflammation markers while you stay on your usual heart medicines.
Boston, MassachusettsAges 45–65 - NCT04575844RecruitingPhase 4
Exercise and GLP-1 to improve insulin and muscle blood flow
This study looks at whether doing exercise and a GLP-1 medicine (liraglutide or similar) can improve how your body uses insulin and how blood flows to your muscles. It is aimed at adults with metabolic syndrome who do not already have diabetes.
Charlottesville, VirginiaAges 21–60 - NCT04512456Recruiting
Exercise training study for people with HIV and heart health
This study looks at how a structured exercise program affects the heart and blood flow in people living with HIV. It may help your care team understand who benefits most from exercise and how to do it safely.
Rio de Janeiro, Rio de JaneiroAges 30–50 - NCT04520139RecruitingPhase 1/Phase 2
NAC to help prevent chemo brain fog in ovarian cancer
This Phase 1/2 study tests whether taking NAC (a supplement medicine) can help prevent or reduce memory and thinking problems after platinum chemotherapy. It targets people with advanced ovarian, fallopian tube, or primary peritoneal cancer who are starting at least six cycles of platinum-based treatment.
Orange, CaliforniaAges 18 years+ - NCT04504721Enrolling by invitation
Light therapy for fibromyalgia using blue-enriched white light
This study tests whether a specific type of light (blue-enriched white light) can reduce symptoms of fibromyalgia. It may help people feel better by changing how the body responds to light.
TaipeiAges 20–64 - NCT04533295Recruiting
Acupuncture to support pregnancy in women with failed IVF
This trial studies whether adding acupuncture during embryo transfer and hormone treatment can improve pregnancy outcomes for women who have had repeat IVF implantation failures with no known cause. It may help your chance of clinical pregnancy when you transfer good-quality frozen embryos.
Wuhan, HubeiAges 25–40 - NCT04504227Recruiting
Testing thickened feeds to improve safe swallowing
This study looks at how using thickened feeds may change swallowing safety and function in children who have swallowing problems (dysphagia) or who are at risk for a type of concerning breathing event. The goal is to see whether thicker liquids help protect the airway and improve swallow patterns.
Boston, MassachusettsAges Up to 21 years - NCT04509050Recruiting
Testing a highly effective CF medicine in young children
This study looks at how well a highly effective cystic fibrosis (CF) medicine works in infants and young children, and what biological changes it causes. It may help families understand whether the medicine improves CF function and related measures early in life.
Birmingham, AlabamaAges Up to 10 years - NCT04589468Recruiting
Exercise for cancer survivors at high risk
This study tests whether a structured exercise program can help prevent cancer from coming back in people who have been treated for certain solid tumors (colorectal, ovarian, lung, or breast cancer). If you've completed surgery and adjuvant therapy within the past 2 years and are currently not exercising much, you may be eligible. Participation involves following an exercise plan and regular check-ins.
Durate, CaliforniaAges 18 years+ - NCT04570085RecruitingPhase 3
Caffeine treatment to improve thinking in Alzheimer’s disease
This trial tests whether changing caffeine intake can improve thinking and brain function in people with Alzheimer’s disease. You may qualify if you can follow a low-caffeine diet and have stable Alzheimer’s treatment and sleep/heart conditions.
AmiensAges 50 years+ - NCT04555785RecruitingPhase 4
Testing platelet treatment in ICU patients after surgery
This trial studies whether a platelet-related treatment can work better in people in the ICU who need a platelet transfusion after surgery. It may help reduce bleeding by improving how platelets work when certain blood clotting proteins are already high.
BaselAges 18 years+
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Common questions
- Are there clinical trials for effectiveness?
- Yes. Clin2 currently lists 6,374 recruiting effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.