Clinical trials
Esketamine clinical trials
Below are recruiting esketamine clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07308756RecruitingPhase 4
Study on two drugs for better recovery after surgery
This trial tests if giving two medicines, dexmedetomidine and esketamine, during and after surgery can help you feel better and recover more comfortably. It is for adults having general anesthesia for at least one hour who will use a patient-controlled pain pump afterward.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07247968RecruitingEarly Phase 1
Esketamine with ECT for severe depression in teens
This study tests whether adding a low dose of esketamine (a type of anesthesia) to modified electroconvulsive therapy (ECT) helps treat severe depression in teenagers. It aims to see if this combination works better and is safer than ECT alone.
ChongqingAges 13–17 - NCT07125573Enrolling by invitation
Esketamine and dexmedetomidine for recovery after lung surgery
This trial tests if adding two medicines (esketamine and dexmedetomidine) during your thoracoscopic (keyhole) lung surgery helps you recover better and feel less discomfort afterward.
Kunming, YunnanAges 18–65 - NCT06399185RecruitingPhase 4
Medicines for catheter discomfort after bladder or prostate surgery
This study tests whether two medicines, dexmedetomidine and esketamine, can reduce discomfort from a urinary catheter after bladder or prostate surgery. If you are having this type of surgery and need a catheter, this trial may help find a better way to manage that discomfort.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07716098RecruitingPhase 3
Esketamine nasal spray for treatment-resistant depression
This study tests esketamine nasal spray versus a placebo in adults with depression that has not improved after trying at least two other antidepressants. It aims to see if the spray can help when standard pills have not worked.
Redlands, CaliforniaAges 18 years+ - NCT07479602RecruitingPhase 4
Medicine via nose for less pain after tonsil surgery in kids
This trial tests whether giving two medicines (dexmedetomidine and esketamine) through the nose can help children ages 3-7 have less pain after their tonsil or adenoid surgery. The goal is to find a better way to manage pain without using strong drugs.
Beijing, Beijing MunicipalityAges 3–7 - NCT06773143Recruiting
Esketamine for sleep quality during breast cancer chemo
This trial tests whether a low dose of esketamine can improve sleep quality in women with breast cancer who are receiving neoadjuvant chemotherapy. If you have trouble sleeping during treatment, this study may find a new way to help.
Nanjing, JiangsuAges 18–65 - NCT06859892RecruitingPhase 4
Drug combo study for better sleep after major surgery
This study tests whether a combination of two medicines, dexmedetomidine and esketamine, can help improve sleep problems after major non-heart surgery. You may be eligible if you are having planned surgery lasting at least one hour and will use a pain pump after surgery.
BeijingAges 18 years+ - NCT06817239Recruiting
Low-dose esketamine for preventing confusion after surgery in older adults
This study tests whether a low dose of the medicine esketamine can help prevent confusion after surgery in older adults at higher risk. You may qualify if you are 65 or older, planning a major non-cardiac surgery, and have certain health conditions like high blood pressure or diabetes.
Fuzhou, FujianAges 65–90 - NCT07050212Recruiting
Sedation study for children having tonsil surgery
This study tests three different medicines to help young children relax before surgery to remove their tonsils and adenoids. It aims to find which medicine works best and is safest for kids ages 2 to 5.
Wuhan, HubeiAges 2–5 - NCT06853431RecruitingPhase 4
Pre-surgery calming medicine for children ages 1 to 6
This study tests a combination of two medicines (dexmedetomidine and esketamine) given as a nasal spray to help children relax before surgery. The goal is to find the best dose that works well with the least side effects.
Wenzhou, ZhejiangAges 1–6 - NCT06087510RecruitingPhase 4
Different doses of esketamine and dexmedetomidine for pain after scoliosis surgery
This trial tests two different doses of esketamine and dexmedetomidine to see which provides better pain relief after scoliosis correction surgery. It aims to improve your recovery and long-term outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06488586Recruiting
Ketamine vs Esketamine for treatment-resistant depression
This trial compares two forms of ketamine—given by IV or as a nasal spray—in people with major depression that hasn't improved after trying at least two other antidepressants. The goal is to see which treatment works better.
Kingston, OntarioAges 18–75 - NCT06778460Recruiting
Esketamine and lidocaine for pain after liver surgery
This trial tests whether two medicines, esketamine and lidocaine, can reduce long-term pain after liver surgery and possibly improve survival. It is for people who are having a planned liver removal (hepatectomy).
Chengdu, SichuanAges 18–75 - NCT06778811RecruitingPhase 4
Sleep quality study for heart surgery patients
This trial studies sleep problems before and after heart surgery. It tests two medicines to see if they can help improve sleep. This may help you recover better after surgery.
Nanjing, JiangsuAges 40–75 - NCT07396220Enrolling by invitation
Psychotherapy with esketamine nasal spray for suicidal thoughts
This study tests combining a specific type of therapy (BCBT-SP) with esketamine nasal spray to help people with treatment-resistant depression who are having ongoing suicidal thoughts. The goal is to see if this combination can reduce suicidal ideation more effectively than either treatment alone.
San Diego, CaliforniaAges 18–70 - NCT07369102RecruitingPhase 4
Esketamine with or without talk therapy for tough depression
This trial tests if adding a type of talk therapy called integration therapy helps esketamine work better for people with depression that hasn't improved with other treatments. You'll receive esketamine, and some people also get guided sessions to reflect on their experiences.
San JuanAges 21–65 - NCT07317206RecruitingPhase 2
Ayahuasca vs Esketamine for PTSD
This trial tests two treatments—ayahuasca and esketamine—to see if they can help people with PTSD. It's for people who have PTSD and no other health problems.
Ribeirão Preto, São PauloAges 18–65 - NCT07324057Recruiting
Medication before surgery to reduce autism-related anxiety in children
This trial tests whether a nose spray given before anesthesia can help children with autism feel calmer and have fewer behavior problems after surgery. It compares two medications, dexmedetomidine and esketamine, to see if they reduce negative post-surgery changes.
Nanjing, JiangsuAges 2–12 - NCT07317232Recruiting
Ayahuasca and Esketamine for Premenstrual Symptoms
This trial is testing whether a plant-based medicine called ayahuasca and a nasal spray (esketamine) can help with premenstrual symptoms. It's only for healthy people without any medical conditions.
Ribeirão PretoAges 18–65 - NCT07317219Recruiting
Ayahuasca and esketamine on body image
This study tests how ayahuasca and esketamine affect how you see your body. Healthy volunteers are needed to help learn more.
Ribeirão Preto, São PauloAges 18–65 - NCT07315074Recruiting
Esketamine for better sleep after surgery in postmenopausal women
This trial tests if a low dose of esketamine, given during anesthesia, can improve sleep quality after lower-limb fracture surgery in postmenopausal women. It aims to find a safe way to help you rest better after your operation.
Jingjiang, JiangsuAges 45 years+ - NCT07230171Recruiting
Short-term S-ketamine for fibromyalgia pain relief
This trial tests if low-dose S-ketamine, given as a short intravenous infusion, can safely improve fibromyalgia pain and other symptoms for people who haven't gotten enough relief from non-drug treatments. S-ketamine is a fast-acting medicine that blocks pain signals and may help reset how the brain processes pain.
BeijingAges 18 years+ - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Birmingham, AlabamaAges 12–17
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Common questions
- Are there clinical trials for esketamine?
- Yes. Clin2 currently lists 46 recruiting esketamine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a esketamine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a esketamine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.