Clinical trials
General Population (no Specific Condition or Disease) clinical trials
Below are recruiting general population (no specific condition or disease) clinical trials, each written for real people, not researchers. We’re tracking 10,548 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04856410Enrolling by invitation
Spaceflight cognitive testing using MRI brain scans
This study looks at how long-duration space travel affects thinking skills, especially memory and spatial navigation, and what changes happen in the brain. It compares astronauts with healthy volunteer “astronaut surrogates” and uses MRI scans to measure brain function.
Philadelphia, PennsylvaniaAges Any age - NCT04897321RecruitingPhase 1
CAR T therapy for children with B7-H3 solid tumors
This early-phase study tests a lab-made immune therapy (CAR T cells) made from your own cells to treat children’s solid tumors that have a specific marker called B7-H3. It is designed for kids whose cancer has come back or did not respond to standard treatment, aiming to shrink tumors and keep the therapy safe.
Memphis, TennesseeAges Up to 21 years - NCT04876131RecruitingPhase 4
Single-dose IV antibiotics for children with complicated urinary tract infections
This trial tests whether one dose of intravenous (IV) antibiotics is as effective as the usual multiple-dose course for children with complicated urinary tract infections (UTIs) who need IV treatment in the emergency department. It aims to reduce hospital stays and the need for repeated IV lines.
Adelaide, South AustraliaAges 3 months–18 years - NCT04920032RecruitingPhase 1
Blood test–guided extra treatment for colon cancer recurrence risk
This Phase 1 study uses a blood test called ctDNA to decide whether and how to adjust treatment in people with colon cancer who still have a small amount of disease left after surgery. If your blood test remains positive, the trial aims to reduce recurrence risk by guiding treatment changes.
Orange, CaliforniaAges 18 years+ - NCT02604277Recruiting
Study of suicidal behavior in people with bipolar disorder
This study looks at suicidal thoughts or behaviors in people diagnosed with bipolar disorder. It may help researchers understand what leads to suicidal risk and how to better support safety and treatment.
Atlanta, GeorgiaAges 18–64 - NCT04299828Recruiting
Study of inflammation activity during complex heart surgery
This study measures how active white blood cells and inflammation are during complex heart surgery using a heart-lung machine. It may help doctors better understand what triggers inflammation during surgery and how to improve care.
Boston, MassachusettsAges Any age - NCT04787744RecruitingPhase 2/Phase 3
Test standard prostate cancer treatment with or without targeted spot radiation
This study tests whether adding targeted local treatment (like radiation to a few spots seen on scans) improves outcomes for some people with limited (oligometastatic) prostate cancer. It compares standard systemic therapy alone versus standard therapy plus PET-scan–guided spot treatment.
Long Beach, CaliforniaAges 18 years+ - NCT04772170Recruiting
Study wearable and symptom monitoring during respiratory virus challenges
This observational study looks for digital health patterns during studies where people are intentionally exposed to a respiratory virus. If you join a respiratory virus challenge at NIH, you may help researchers discover better ways to monitor and understand illness using wearable devices and shared health data.
Bethesda, MarylandAges 18–65 - NCT04781322RecruitingPhase 1
Study drug to reduce LDL cholesterol effects in heavy drinkers
This Phase 1 study tests how safe a cholesterol-lowering antibody (alirocumab) is in people who drink heavily but are not seeking alcohol treatment. It also looks at early drug effects in the body to see how it might change cholesterol-related signals.
Bethesda, MarylandAges 21–65 - NCT04799301RecruitingPhase 1
Measure how much sugar you eat using blood and hair samples
This Phase 1 study tests whether “biomarkers” in your blood and hair can accurately measure how much sugar you consume. It may help researchers find better ways to track dietary sugar intake in future nutrition and health studies.
Phoenix, ArizonaAges 18–65 - NCT03894917Recruiting
Study blood and imaging features in older adults with liver cancer
This study looks at what liver cancer is like in newly diagnosed people who are older and whose cancer cannot be removed by surgery. It may help doctors better understand disease behavior and how treatments may work and affect the body.
San Antonio, TexasAges 18 years+ - NCT04071847Recruiting
Study tracking results after Abbott deep brain stimulator surgery
This study follows people who are getting a new Abbott deep brain stimulator (DBS) device or replacing the battery/implantable pulse generator to see how outcomes change over time. It mainly applies to certain DBS targets and diagnoses, and it uses follow-up visits to track results.
Tucson, ArizonaAges Any age - NCT04640987RecruitingPhase 1
Stem cell transplant with added T-cells for blood cancers
This Phase 1 study tests a stem cell transplant plan that uses donor T-cells that have been specially processed and then added back. It aims to see if this approach is safer and works better for children and adults with serious blood cancers who need a transplant.
Palo Alto, CaliforniaAges 1 month–45 years - NCT04644211RecruitingPhase 2
Ruxolitinib for symptom control in certain blood cancer types
This Phase 2 study tests ruxolitinib (a targeted medicine) in people with essential thrombocythemia or polycythemia vera who still have troublesome symptoms. It aims to see whether it can reduce symptoms by changing disease activity and blood-related inflammation.
Boston, MassachusettsAges 18 years+ - NCT04833465Recruiting
Testing a new outcome measure in kids with rheumatology diseases
This study looks at how to measure treatment success in children with juvenile idiopathic arthritis (JIA), lupus (SLE), or fibromyalgia (FM). It may help doctors track symptoms more reliably over time.
Washington D.C., District of ColumbiaAges 5–21 - NCT04794530RecruitingPhase 3
Cocoa extract trial for walking problems in blocked leg arteries
This Phase 3 study tests whether cocoa extract (cocoa flavanols) can improve walking ability and circulation in people with peripheral artery disease (PAD). It may help people who have PAD-related walking limits and can safely avoid competing cocoa sources and caffeine.
Chicago, IllinoisAges 55 years+ - NCT04791748Recruiting
Virtual reality balance training for kids with inner-ear problems
This study uses virtual reality tasks to understand and compare balance and movement in children with long-term inner-ear (vestibular) problems versus those without. It may help doctors learn what supports best balance and safety during daily activities.
ParisAges 7 years+ - NCT04812314Recruiting
Study how exercise changes body fat and metabolism
This study looks at how starting exercise changes the structure and function of body fat. It may help you understand how exercise affects things like cholesterol and blood sugar, even if you’re not currently exercising regularly.
Ann Arbor, MichiganAges 18–40 - NCT04851015RecruitingPhase 3
Low-dose TMP-SMX for Pneumocystis pneumonia (PCP)
This Phase 3 study tests whether low-dose trimethoprim-sulfamethoxazole (also called TMP-SMX) can treat Pneumocystis pneumonia (PCP) in people with weakened immune systems. It may help improve treatment while reducing side effects compared with standard dosing.
Montreal, QuebecAges 18–100 - NCT04824066Recruiting
Using wearables to spot complications early
This study checks whether common wearable devices can predict or detect problems after treatment or surgery. If you join, the researchers will compare what the wearable shows with what happens to you medically, to see if earlier warnings are possible.
Boston, MassachusettsAges 18 years+ - NCT04797286RecruitingPhase 2
Sildenafil for early lung blood-pressure problems in scleroderma
This trial tests whether sildenafil can improve early “high pressure in the lung blood vessels” in people with scleroderma. It may help slow worsening breathing and lung blood-vessel disease before it becomes severe.
New Orleans, LouisianaAges 18 years+ - NCT04809688Enrolling by invitation
Study how berries affect metabolism and gut bacteria
This study looks at whether eating Saskatoon berries changes how your body uses energy (metabolism) and how your gut bacteria behave. It’s done in healthy people and may help researchers understand how foods could support overall health.
Winnipeg, ManitobaAges 18–75 - NCT04848025Recruiting
Custom 3D stents made for blocked airways
This trial studies a computer-planned, custom-made 3D stent to open up narrow, blocked areas of the main airway near the chest. It may help reduce breathing trouble and cough, and prevent complications from the blockage.
Toulouse, ToulouseAges 18 years+ - NCT04815694Recruiting
MRI-guided radiotherapy for rectal cancer
This trial tests whether using MRI scans to guide radiotherapy can improve treatment for people with a certain type of rectal cancer. It focuses on patients whose tumors have not spread to other parts of the body and who have specific tumor features seen on MRI.
Roma, RomaAges 18 years+
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Common questions
- Are there clinical trials for general population (no specific condition or disease)?
- Yes. Clin2 currently lists 10,548 recruiting general population (no specific condition or disease) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a general population (no specific condition or disease) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a general population (no specific condition or disease) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.