Head and Neck Surgery clinical trials

Antibiotics after head and neck surgery study

This trial tests whether giving antibiotics after certain head and neck surgeries helps prevent infections. It is for people having planned (non-emergency) surgery that involves entering a normally clean area that may have some germs, like the mouth or throat.

RiMO-301 plus radiation with PD-1 therapy for head-neck cancer

This trial studies RiMO-301 injection combined with palliative radiation and a PD-1 immune therapy (pembrolizumab or nivolumab) for head and neck cancer that cannot be fully removed. It aims to see whether this approach can shrink tumors and improve outcomes safely.

Virtual rehab program for cancer survivors

This trial tests a virtual (online) rehabilitation and exercise program for people after breast, colorectal, head and neck, or certain blood cancers. It may help improve recovery and daily functioning by supporting safe activity and targeted rehab after treatment.

TMV vaccine alone or with pembrolizumab for advanced HNSCC

This trial tests a vaccine made from your own tumor to help your immune system fight head and neck cancer that has returned or spread. It is given alone or with an immunotherapy drug (pembrolizumab) to see if it can shrink tumors or slow progression.

Salvage surgery study for recurrent head and neck skin-cell cancer

This study looks at how well people do after “salvage” surgery (planned surgery after prior treatment) for recurrent or residual squamous cell cancer in the head and neck. It may help doctors understand which patients benefit most, including how this surgery affects survival and day-to-day function.

Study of IBI110 and Sintilimab with Chemo for Head and Neck Cancer

This trial tests a combination of two immunotherapy drugs (IBI110 and sintilimab) with chemotherapy before surgery for people with advanced head and neck cancer that can be removed surgically. The goal is to see if this approach helps shrink tumors and improve outcomes.

Drug combination before surgery for recurrent head and neck cancer

This trial tests three drugs (finotonlimab, cetuximab, and docetaxel) given before surgery to remove recurrent head and neck cancer in patients whose cancer stopped responding to previous immunotherapy. The goal is to shrink the tumor and improve surgical outcomes.

Home-Based Exercise Program for Head and Neck Cancer Patients

This study tests whether patients recovering from head and neck cancer surgery can safely do supervised exercise exercises at home. The program aims to help you regain strength and function during your recovery.

Panitumumab-IRDye800 during head and neck surgery

This Phase 2 study tests a targeted medicine (panitumumab-IRDye800) given around the time of surgery for head and neck squamous cell cancer. It aims to improve doctors’ ability to find and remove cancer tissue during planned surgery.

Pembrolizumab before surgery or radiation for high-risk skin SCC

This Phase 2 trial tests pembrolizumab (an immune therapy) given before surgery to see if it can help control high-risk invasive cutaneous squamous cell carcinoma. The goal is to improve outcomes by treating cancer earlier and then following with standard surgery and radiation if needed.

Radiation plus immunotherapy for recurrent head and neck cancer

This study tests whether adding an immunotherapy medicine called tislelizumab to radiation can better control recurrent (coming back) head and neck squamous cell cancer. It is aimed at people whose cancer can’t be fully removed by surgery or can’t be safely removed.

Chemo plus cetuximab after pembrolizumab for head and neck cancer

This trial tests a combination of two chemotherapy drugs (carboplatin and paclitaxel) plus a targeted therapy (cetuximab) for people with advanced head and neck cancer that has gotten worse after treatment with pembrolizumab (with or without initial chemotherapy). The goal is to see if this new combination can shrink tumors or slow the cancer's growth.

Gene therapy injection for advanced head and neck cancer

This trial tests a new treatment where a specially designed virus carrying an anti-cancer gene is injected directly into tumors in the head and neck area. It's for patients whose cancer has come back or spread after prior chemotherapy and who cannot have surgery or radiation.

Tislelizumab plus chemo before surgery vs surgery alone for head and neck cancer

This trial tests whether giving tislelizumab (an immunotherapy) with chemotherapy before surgery works better than surgery alone for people with head and neck cancer that has not spread to lymph nodes. It's for cancers that can be removed with surgery, and the goal is to see if the pre-surgery treatment improves outcomes.

Study of PD-L1 antibody plus chemo before surgery for head and neck cancer

This trial tests whether adding a PD-L1 antibody (Adabelimab) to standard chemotherapy before surgery can help treat advanced head and neck squamous cell carcinoma. It is for people who have not had treatment for this cancer before and are well enough to undergo the therapy.

New drug combination for recurrent head and neck cancer

This trial tests two drugs—becotatug vedotin and pucotenlimab—given before surgery to treat head and neck cancer that has come back in the same area. The goal is to shrink the tumor and help your body's immune system fight the cancer.

Topical Boswellia Serrata 2% to Prevent Radiation Dermatitis in Head and Neck Cancer

Antibiotics before surgery for oral cancer

This trial tests if taking antibiotics and using a mouth rinse before surgery can help treat oral cancer by targeting bacteria inside the tumor. It is for people with a new diagnosis of oral cancer who are scheduled for surgery.

BNCT radiation therapy for head and neck cancer

This trial tests a type of radiation therapy called BNCT (boron neutron capture therapy) for people with head and neck cancer that cannot be surgically removed. It may be an option if you have already had radiation or chemo and have no distant spread of cancer.

Photoacoustic scans for untreated head and neck cancer

This study tests a special imaging scan (photoacoustic imaging) to help doctors look at head and neck cancer before treatment. It’s for people who have not had first-line therapy yet and will be starting radiotherapy.

At-home integrative program for people living with cancer

This study tests an at-home integrative medicine program (supportive, whole-person care) to see if it helps symptoms like fatigue for people affected by cancer. You may be assigned to the program or a comparison group, and you’ll complete questionnaires and study check-ins from home.

Adaptive radiation planning using FMISO imaging for head and neck cancer

This trial tests a way to personalize radiation treatment using a special scan (FMISO) to improve targeting in certain head and neck cancers. It is designed for people who are newly diagnosed and ready for standard curative (definitive) chemoradiation or faster radiation schedules.

Study of immune signals in head and neck cancer

This study looks at “immune signals” in blood, saliva, and stool to learn more about head and neck cancers (especially squamous cell carcinoma). It may help researchers find patterns that improve understanding of disease or how treatment should be guided.

Exercise program for people getting treatment for head and neck cancer

This trial tests whether a preventive, structured physical activity program can help people during and around curative treatment for head and neck cancers. It aims to see if exercise is safe and beneficial for strength, function, and well-being during radio(±chemo) therapy.